Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Steve Pakola"'
Autor:
Heather Schmitt, Astrid F. Nottebaum, Ute Ipe, Mitchell Brigell, Sarthak Mishra, Barbara Withers, Dietmar Vestweber, Brandi Soldo, Iris Navarro, Steve Pakola, W. Daniel Stamer, Kevin G. Peters, Guorong Li, Maria Gomez-Caraballo
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP, making the angiopoietin/Tie2 pathway a target for new and potentially disease modify
OR14-6 The Role of the Angiopoietin-Tie2 Pathway in Microvascular Complications of Diabetes Mellitus
Publikováno v:
Journal of the Endocrine Society
INTRODUCTION: The Tie2 pathway is a key regulator of vascular stability. Deactivation of this pathway, caused by hyperglycemia or ischemia, results in pathological vascular inflammation, permeability and neovascularization. AKB-9778 is a small molecu
Autor:
Aerpio Therapeutics, Inc.
Publikováno v:
Business Wire (English). 10/06/2015.
Autor:
Aniz Girach, Steve Pakola
Publikováno v:
Expert Review of Ophthalmology. 7:311-323
Over the past two decades, the role of vitreomacular adhesion in vitreomacular interface pathologies, such as vitreomacular traction syndrome, epiretinal membrane and macular hole, has been increasingly recognized. Abnormalities of the vitreoretinal
Autor:
Jean-Marie Stassen, Titti Martinsson-Niskanen, Steve Pakola, Leonard Larsson, Steven Glazer, Lena Winstedt, Rikke Riisbro, Yvonne Stenberg
Publikováno v:
Clinical Therapeutics. 33:1142-1149
Background TB-403 (RO5323441) is a humanized monoclonal antibody directed against placental growth factor (PlGF). Preclinical studies have demonstrated that targeting PlGF can result in significant inhibition of tumor growth and metastasis. Objective
Autor:
Elisabeth Sonesson, Peter Verhamme, Kathelijne Peerlinck, Jean-Marie Saint-Remy, Torben Balchen, Kristina Berggren, Steve Pakola, Steven Glazer, Geraldine Cahillane, Thomas Jensen, Ann Belmans, Marc Jacquemin, Jean-Marie Stassen
Publikováno v:
Clinical Therapeutics. 32:1205-1220
Background: TB-402, a human monoclonal antibody that partially inhibits Factor VIII activity (FVIII:C), is being developed as a long-acting antithrombotic agent. Objectives: The primary goal of this study was to investigate the tolerability of TB-402
Autor:
PR Newswire
Publikováno v:
PR Newswire Europe. 05/11/2012.
Autor:
Steve Pakola, Julia A. Haller
Publikováno v:
Diseases of the Vitreo-Macular Interface ISBN: 9783642400339
Pharmacologic vitreolysis refers to the administration of an agent to induce vitreous liquefaction and/or vitreoretinal separation in an attempt to treat vitreoretinal disorders. Enzymes that target one or more of the substrates that make up the vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2741ea6495416cf03acb2c63f0cae73
https://doi.org/10.1007/978-3-642-40034-6_11
https://doi.org/10.1007/978-3-642-40034-6_11
Publikováno v:
Retina (Philadelphia, Pa.). 30(7)
PURPOSE Vitreomacular adhesion causing vitreomacular traction is a common indication for vitrectomy. It may be avoided by using enzymatic vitreolysis. The MIVI-IIT (traction) study evaluated the ability of a single or repeated injection of microplasm
Publikováno v:
Clinical therapeutics. 31(8)
Background: Microplasmin is the isolated proteinase domain of plasmin. Administration of microplasmin has been found to neutralize α 2 -antiplasmin (α 2 -AP) activity, which has been associated with reduced infarct size in various preclinical model