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pro vyhledávání: '"Steve O. Moore"'
Autor:
Norman Lewis, Steve O. Moore, Michael Urquhart, Bernie M. Choudary, Florence Jovic, Giles Robert Gordon
Publikováno v:
Organic Process Research & Development. 16:1927-1939
A synthesis of the pleuromutilin antibiotic SB-268091 is described which includes a new and improved route to the quinuclidine-4-thiol ligand. This chemistry has been run on multikilo scale and involved a reductive double debenzylation using sodium i
Autor:
Andrew H. Gordon, Michael Urquhart, Matthew J. Peterson, Steve O. Moore, Richard K. Bellingham, A. Mark Buswell, Amin Shamji, Mike Sasse, Bernie M. Choudary
Publikováno v:
Organic Process Research & Development. 14:1254-1263
The discovery and development of an efficient manufacturing route to the CENP-E inhibitor 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}−4-[(1-methylethyl)oxy]benzamide (