Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steve Mullin"'
Publikováno v:
Global Ecology and Conservation, Vol 56, Iss , Pp e03273- (2024)
Tropical oceanic islands are critical biodiversity hotspots where population monitoring can help to determine the status and trends of rare and endangered species. Saipan is the second largest island in the Mariana Islands and contains many endemic a
Externí odkaz:
https://doaj.org/article/35f6412229724264897c7d58044b0228
Publikováno v:
Journal of Antimicrobial Chemotherapy. 69:41-44
Objectives: Current treatments for Clostridium difficile infection include vancomycin, metronidazole, and fidaxomicin. LFF571 is an experimental agent undergoing evaluation in humans for the treatment of moderate C. difficile infection. Reduced susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98307eef92d87bb7ad1c2db7dc138ec
https://doi.org/10.1093/jac/dkt302
https://doi.org/10.1093/jac/dkt302
Autor:
Brian L. Hanzelka, Jonathan D. Parsons, Trudy H. Grossman, Anne-Laure Grillot, Dean Stamos, Steve Mullin, Nagraj Mani, Paul S. Charifson, Ute Müh, Yusheng Liao, Christian H. Gross
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:1228-1237
Antibiotics with novel mechanisms of action are becoming increasingly important in the battle against bacterial resistance to all currently used classes of antibiotics. Bacterial DNA gyrase and topoisomerase IV (topoIV) are the familiar targets of fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ebac515f56ea117384a302503d5e2c
https://doi.org/10.1128/aac.50.4.1228-1237.2006
https://doi.org/10.1128/aac.50.4.1228-1237.2006
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:4171-4176
Inhibitors of mammalian multidrug efflux, such as the plant alkaloid reserpine, are also active in potentiating antibiotic activity by inhibiting bacterial efflux. Based on this precedent, two novel mammalian multiple drug resistance inhibitors, biri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa1ce25c50975f7262240b70a355f71
https://doi.org/10.1128/aac.48.11.4171-4176.2004
https://doi.org/10.1128/aac.48.11.4171-4176.2004
Publikováno v:
All Days.
This paper highlights key knowledge that was shared at the SPE Collision Avoidance and Well Interceptions Applied Technology Workshop held in Inverness, September 2012. It has been written to raise awareness of critical issues concerning well bore co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca90c48a26202f6f174a0b57cc941063
https://doi.org/10.2118/163411-ms
https://doi.org/10.2118/163411-ms
Publikováno v:
Antimicrobial agents and chemotherapy. 56(8)
LFF571 is a novel semisynthetic thiopeptide and potent inhibitor of Gram-positive bacteria. We report that the antibacterial activity of LFF571 against Clostridium difficile is due to inhibition of translation. Single-step mutants of C. difficile wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9544a21c5ba5762cca207d67dd89516b
https://pubmed.ncbi.nlm.nih.gov/22644023
https://pubmed.ncbi.nlm.nih.gov/22644023
Autor:
Qingming Zhu, Bushell Simon, Stacey Tiamfook, JoAnne Dzink-Fox, Michael A. Patane, Jason T. Brewer, Deborah Palestrant, Elin M. Rann, Matthew J. LaMarche, Meena Sachdeva, Anna Trzasko, Lewis Whitehead, Jennifer A. Leeds, Steve Mullin, Janetta Dewhurst, Lac Lee, Wanlin Yan, David McKenney, Gabriel G. Gamber, Jian Ding, Aregahegn Yifru, Adam Amaral, Jian Shao, Donghui Yu, Gejing Deng, Kwangho Lee, Troy Lister, Colin P. Osborne, Akash Jain
Publikováno v:
Journal of medicinal chemistry. 55(5)
Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the lumen of the large intestine and produces toxins. This results in a range of syndromes from mild diarrhea to severe toxic megacolon and death. Alarmingly, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c1bda3979597c478a8efdea5840cb
https://pubmed.ncbi.nlm.nih.gov/22315981
https://pubmed.ncbi.nlm.nih.gov/22315981
Autor:
Jennifer A. Leeds, Eric Gangl, Georg Neckermann, Jason T. Brewer, Julie Goldovitz, JoAnne Dzink-Fox, Bushell Simon, Akash Jain, Stacey Tiamfook, Deborah Palestrant, Michael A. Patane, Lewis Whitehead, Elin M. Rann, Steve Mullin, Colin Osborne, Matthew J. LaMarche, Kerri Amaral, Janetta Dewhurst, Jian Shao, Donghui Yu, Meena Sachdeva
Publikováno v:
Journal of medicinal chemistry. 54(23)
4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their activity against Gram positive bacterial infections. Optimization efforts focused on improving the physicochemical propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917eae7075592660485c48aaf879a366
https://pubmed.ncbi.nlm.nih.gov/21999529
https://pubmed.ncbi.nlm.nih.gov/21999529
Autor:
JoAnn Dzink-Fox, Deborah Palestrant, Akash Jain, Bushell Simon, Meena Sachdeva, Jason T. Brewer, Stacey Tiamfook, Maria-Dawn Lilly, Eric Gangl, Lewis Whitehead, Alejandra Raimondi, Srijan Ranjitkar, Michael A. Patane, Matthew J. LaMarche, Steve Mullin, Elin M. Rann, Lac Lee, Georg Neckermann, Kari Manni, Jennifer A. Leeds, Janetta Dewhurst, Jian Shao, Colin Osborne, Donghui Yu, Gejing Deng
Publikováno v:
Antimicrobial agents and chemotherapy. 55(11)
Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like GE2270 A, target the essential bacterial protein elongation factor Tu (EF-Tu). Medicinal chemistry optimization of lead molecules led to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacc6276d0efb008e92187e85d6546f5
https://pubmed.ncbi.nlm.nih.gov/21825297
https://pubmed.ncbi.nlm.nih.gov/21825297
Autor:
Matthew J. LaMarche, Jennifer A. Leeds, JoAnne Dzink-Fox, Michael Patane, Steve Mullin, Elin M. Rann, Stacey Tiamfook
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
Imidazole analogs of the antibiotic natural product GE2270 A (1) were designed, synthesized, and evaluated for Gram positive bacteria growth inhibition. A recently reported, copper-mediated synthesis was exploited to prepare 4-thiazolyl imidazole ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e30d41d731a91ce35828241d38c358a
https://pubmed.ncbi.nlm.nih.gov/21550238
https://pubmed.ncbi.nlm.nih.gov/21550238