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Autor:
David B. Buckley, Brian W. Ogilvie, Phyllis Yerino, Jeff Holsapple, Brandy L. Paris, Andrew Parkinson, Paul Toren, Faraz Kazmi, Steve M. Otradovec
Publikováno v:
Drug Metabolism and Disposition. 39:1370-1387
Metabolism-dependent inhibition (MDI) of cytochrome P450 is usually assessed in vitro by examining whether the inhibitory potency of a drug candidate increases after a 30-min incubation with human liver microsomes (HLMs). To augment the IC(50) shift,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1fab71bbfccfffb3aba39f25cb4257
https://doi.org/10.1124/dmd.111.038596
https://doi.org/10.1124/dmd.111.038596
