Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease

Autor: Anabel Gonzalez-Gil, Ryan N. Porell, Steve M. Fernandes, Eila Maenpaa, T. August Li, Tong Li, Philip C. Wong, Kazuhiro Aoki, Michael Tiemeyer, Zaikuan J. Yu, Benjamin C. Orsburn, Namandjé N. Bumpus, Russell T. Matthews, Ronald L. Schnaar

Publikováno v: The Journal of biological chemistry. 298(6)

Alzheimer's disease (AD) is characterized by accumulation of misfolded proteins. Genetic studies implicate microglia, brain-resident phagocytic immune cells, in AD pathogenesis. As positive effectors, microglia clear toxic proteins, whereas as negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb031eecb1b4993611c6702a90c6315d
https://pubmed.ncbi.nlm.nih.gov/35452678

Probing the binding specificities of human Siglecs by cell-based glycan arrays

Autor: James C. Paulson, Julie Van Coillie, Henrik Clausen, Zhang Yang, Sam J. Moons, Ryan McBride, Gosse J. Adema, Corwin M. Nycholat, Sanae Furukawa, Thomas J. Boltje, Ronald L. Schnaar, Rebecca Nason, Daniel Madriz Sørensen, Lingbo Sun, Steven Arbitman, Steve M. Fernandes, Yoshiki Narimatsu, Christian Büll

Publikováno v: Proceedings of the National Academy of Sciences USA, 118, 17
Proceedings of the National Academy of Sciences
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences USA, 118

Item does not contain fulltext Siglecs are a family of sialic acid-binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell functions upon recognition of sialoglycan ligands. While human S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c46f0e780996fd9967df451fcb70533
https://repository.ubn.ru.nl/handle/2066/235326

Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8

Autor: T. August Li, Kazuhiro Aoki, Anabel Gonzalez-Gil, Ronald L. Schnaar, Haley E. Tarbox, Ryan N Porell, Jean Kim, Steve M. Fernandes, Hyun Sil Lee, Michael Tiemeyer

Publikováno v: J Allergy Clin Immunol

Background The immunoinhibitory receptor Siglec-8 on the surface of human eosinophils and mast cells binds to sialic acid–containing ligands in the local milieu, resulting in eosinophil apoptosis, inhibition of mast cell degranulation, and suppress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc658ee531861a0be66fdd566e2075f1
https://pubmed.ncbi.nlm.nih.gov/32791164

Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties

Autor: James C. Paulson, Yadong Wei, Anabel Gonzalez-Gil, Huifeng Yu, Ronald L. Schnaar, Corwin M. Nycholat, Katarina Vajn, Steve M. Fernandes, Ryan N Porell

Publikováno v: Glycobiology. 27:657-668

Siglecs are transmembrane sialoglycan binding proteins, most of which are expressed on leukocyte subsets and have inhibitory motifs that translate cell surface ligation into immune suppression. In humans, Siglec-8 on eosinophils, mast cells and basop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0d7cf53505bf9811da3a463a3daa2e
https://doi.org/10.1093/glycob/cwx026

Immunoregulatory Siglec ligands are abundant in human and mouse aorta and are up-regulated by high glucose

Autor: Ronald L. Schnaar, Qianjin Zhong, Yu Zheng, Yijie Hu, Fangjie Wang, Jin Li, Yingxian Zhang, Yi Jia, Hongmei Liu, Ling Nie, Xiaohui Li, Steve M. Fernandes

Publikováno v: Life sciences. 216

Aim Inflammation is a driving force in development of atherosclerosis, and hyperglycemia is a significant risk factor for angiopathy. Siglec-9, expressed on human neutrophils and macrophages, engages specific glycan ligands on tissues to diminish ong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7c2aaa5f2dccaed96d9a910649176a
https://pubmed.ncbi.nlm.nih.gov/30471282