Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Steve M Patrick"'
Autor:
Mohammed Hafiz Uddin, Jun-Ying Zhou, Julio Pimentel, Steve M. Patrick, Seongho Kim, Malathy P. Shekhar, Gen Sheng Wu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) are currently being used for treating breast cancer patients with deleterious or suspected deleterious germline BRCA-mutated, HER2-negative locally advanced or metastatic diseases. Despite durab
Externí odkaz:
https://doaj.org/article/b87f14cd879b42a5aa08d654566b9494
Autor:
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, Katherine S. Pawelczak
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for
Externí odkaz:
https://doaj.org/article/1d4434aabcf24c4eb69ee21c9ff5887f
Autor:
Jordan M. White, Nicholas Ramos, Allen-Dexter Saliganan, Joon-Yong Chung, Meghan Bell, Jacob Lindquist, Kayla Conner, Wendy N. Wiesend, Michael Schopperle, Steve M. Patrick, Seongho Kim, Elisabeth I. Heath, Freddy E. Escorcia, Nerissa T. Viola
Publikováno v:
Theranostics. 13:2057-2071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc729e20192e112d68e811f20b556eb
https://doi.org/10.7150/thno.78915
https://doi.org/10.7150/thno.78915
Autor:
Steve M. Patrick, Gerold Bepler, Ann G. Schwartz, Jessica B. Back, Wei Chen, Hao Zhang, Donovan Watza, Wen Lei, Joshua R. Heyza
Supplemental Figure S1. A. Clonogenic survival assays with cisplatin treatment in p53WT cell lines {plus minus} ERCC1. B. Clonogenic survival assays with cisplatin treatment in p53 null and p53mutant cell lines {plus minus} ERCC1. n = 3 independent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390a3c05023ae6b47bc794fde75bdfed
https://doi.org/10.1158/1078-0432.22471092.v1
https://doi.org/10.1158/1078-0432.22471092.v1
Autor:
Steve M. Patrick, Gerold Bepler, Ann G. Schwartz, Jessica B. Back, Wei Chen, Hao Zhang, Donovan Watza, Wen Lei, Joshua R. Heyza
Purpose:ERCC1/XPF is a DNA endonuclease with variable expression in primary tumor specimens, and has been investigated as a predictive biomarker for efficacy of platinum-based chemotherapy. The failure of clinical trials utilizing ERCC1 expression to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338207b154a3f88ef703b548b31266c8
https://doi.org/10.1158/1078-0432.c.6527781.v1
https://doi.org/10.1158/1078-0432.c.6527781.v1
Autor:
Kandace J. Williams, Vishal P. Sharma, Saravanan Kaliyaperumal, Steve M. Patrick, Anbarasi Kothandapani, Allen G. Schroering
Supplementary Figure 1 from Prolonged Cell Cycle Response of HeLa Cells to Low-Level Alkylation Exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134d0686ae15f8205a3f0bb5a4267e48
https://doi.org/10.1158/0008-5472.22379001.v1
https://doi.org/10.1158/0008-5472.22379001.v1
Autor:
Kandace J. Williams, Vishal P. Sharma, Saravanan Kaliyaperumal, Steve M. Patrick, Anbarasi Kothandapani, Allen G. Schroering
Alkylation chemotherapy has been a long-standing treatment protocol for human neoplasia. N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) is a direct-acting monofunctional alkylator. Temozolomide is a clinical chemotherapeutic equivalent requiring metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d70b504aa94366b52310e86bef3dd0
https://doi.org/10.1158/0008-5472.c.6499083.v1
https://doi.org/10.1158/0008-5472.c.6499083.v1
Autor:
Joshua R Heyza, Elmira Ekinci, Jacob Lindquist, Wen Lei, Christopher Yunker, Vilvanathan Vinothkumar, Rachelle Rowbotham, Lisa Polin, Natalie G Snider, Eric Van Buren, Donovan Watza, Jessica B Back, Wei Chen, Hirva Mamdani, Ann G Schwartz, John J Turchi, Gerold Bepler, Steve M Patrick
Publikováno v:
NAR Cancer. 5
ERCC1/XPF is a heterodimeric DNA endonuclease critical for repair of certain chemotherapeutic agents. We recently identified that ERCC1- and p53-deficient lung cancer cells are tolerant to platinum-based chemotherapy. ATR inhibition synergistically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94ec637d5585b431f6036b27bcf6935
https://doi.org/10.1093/narcan/zcac045
https://doi.org/10.1093/narcan/zcac045
Autor:
Daniel P. Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M. Merkel
Publikováno v:
Molecules, Vol 25, Iss 8, p 1994 (2020)
Platinum-based chemotherapy remains a mainstay treatment for the management of advanced non-small cell lung cancer. A key cellular factor that contributes to sensitivity to platinums is the 5′-3′ structure-specific endonuclease excision repair cr
Externí odkaz:
https://doaj.org/article/a08d71c9cfa94092b6f0b5151adda9cb
Autor:
Agnes Malysa, Wenlong Bai, Hyejeong Jang, Steve M. Patrick, Joseph A. Caruso, Chen Hu, Joshua Heyza, Cong li Hu, Paul M. Stemmer, Niko Moses, Xiaohong Mary Zhang, Gerold Bepler, Wei Chen, Zhenkun Lou, Lisa Polin, Shengyan Xiang, Mu Zhang, Chuangui Wang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-18 (2020)
Cell Death & Disease
Cell Death & Disease
Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and oncogenes in a context-dependent manner. However, the nature of USP10’s role in non-small cell lung cancer (NSCLC) remains unclear. By analyzing The Cancer Genome Atlas (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8387a37b13c5864bed4364357aa1505e
http://link.springer.com/article/10.1038/s41419-020-2519-8
http://link.springer.com/article/10.1038/s41419-020-2519-8