Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steve Ludbrook"'
Autor:
Loveleena Bansal, Eva-Maria Nichols, Daniel P. Howsmon, Jessica Neisen, Christina M. Bessant, Fraser Cunningham, Sebastien Petit-Frere, Steve Ludbrook, Valeriu Damian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few
Externí odkaz:
https://doaj.org/article/af21613b5ce7409b84db7d116ea2d036
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2426, p 2426 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7877645a92e031b77d5ee9829630b2ed
https://doi.org/10.3390/ijms22052426
https://doi.org/10.3390/ijms22052426
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(8)
The arginyl-glycinyl-aspartic acid (RGD) integrin subfamily contains five members that partner with the αv subunit: αvβ1, αvβ3, αvβ5, αvβ6, and αvβ8. Within the αv integrins, the epithelially restricted αvβ6 has been identified as playi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3df95304223d648aa9ab81c90d7bd5c
https://pubmed.ncbi.nlm.nih.gov/28414923
https://pubmed.ncbi.nlm.nih.gov/28414923
Autor:
Scott Davis, Andrew Lake, Steve Ludbrook, Metul Patel, Poonam Shah, Jonathan Hill, Rob Jepras, Gregory Wands, Gary Bonhert
Publikováno v:
Single Cell Analysis ISBN: 9789811044984
The increasing use of disease-relevant human primary cells in cellular target assays in drug discovery and phenotypic screening is driving the requirement for more sensitive high-throughput technologies that derive maximum information from fewer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0658f3ef84ac1bb867f9d843a93314
https://doi.org/10.1007/978-981-10-4499-1_11
https://doi.org/10.1007/978-981-10-4499-1_11
Autor:
Andy Blanchard, Ramla O. Awais, Steve Ludbrook, R. Gisli Jenkins, Alan C. Perkins, Jeni Luckett, Amanda L. Tatler, Ami Desai, Anthony Habgood, Alison E. John, John Marshall
Publikováno v:
Journal of Nuclear Medicine. 54:2146-2152
Transforming growth factor b activation by the avb6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the avb6 integrin is increased in fibrotic lung tissue and is a promising therapeutic target for treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81a1257d69273279528f02d44e3e0b
https://doi.org/10.2967/jnumed.113.120592
https://doi.org/10.2967/jnumed.113.120592
Autor:
Rebecca H. Graves, Elaine Gower, Richard P. Marshall, Pan Procopiou, Andrew J. Fisher, Giovanni Vitulli, Ellen J. Forty, Tao Pun, Steve Ludbrook, Simon J. F. Macdonald, Anderson Niall Andrew, Jane Denyer, Alison E. John, David C. Budd, Susan Pyne, Gisli Jenkins, John Pritchard, Pauline T. Lukey, David J. Flint, John Marshall, Rachel C. Chambers, Valerie S. Morrison, Carmel B. Nanthakumar, Paul F. Mercer, Robert J. Slack
Publikováno v:
QJM: An International Journal of Medicine.
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality in disorders that include IPF. The αvβ6 integrin has been identified as playing a key role in the activation of TGFβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7464da6e9014e4cc1e1841f8366720bf
https://doi.org/10.1093/qjmed/hcw120.013
https://doi.org/10.1093/qjmed/hcw120.013
Autor:
Rebecca F. Rogers, Steve Ludbrook, David J. Flint, Jane Denyer, John Marshall, Susan Pyne, Maryam Hafeji, Robert J. Slack
A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin. It has been shown to be an informative tool ligand in pre-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e2902c8acffe79e87fbd6f7028ea52
https://strathprints.strath.ac.uk/55205/1/Slack_etal_Pharmacology2016_v_6_integrin_binding_and_internalization_kinetics_of_the_foot_and_mouth.pdf
https://strathprints.strath.ac.uk/55205/1/Slack_etal_Pharmacology2016_v_6_integrin_binding_and_internalization_kinetics_of_the_foot_and_mouth.pdf
Autor:
Don O. Somers, Amanda J. Campbell, Dave Mallett, Rosannah Pearson, David D. Miller, Kenneth David Down, Steve Ludbrook, Maria Gerelle, Geoff W. Mellor, John A. Christopher, Yemisi E. Solanke, Keith P. Ray, Paul Bamborough, Catherine M. Alder
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3936-3940
A novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685f09a34eb6c6406209700b29cb445e
https://doi.org/10.1016/j.bmcl.2010.05.011
https://doi.org/10.1016/j.bmcl.2010.05.011
Autor:
Penny A. Smee, Stephen Sean Flack, Steve Ludbrook, Ann Louise Walker, Timothy Longstaff, Mark James Bamford, Paul Bamborough, Katherine Louise Jones, Chun-wa Chung, Rosannah Pearson, Tony D. Angell, Dramane I. Laine, Stuart G. Cockerill, Smith Kathryn Jane, Richard Martyn Angell, Don O. Somers
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
The biphenyl amides (BPAs) are a series of p38alpha MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation, depending on substituents. X-ray, binding, kinetic and cellular data are shown, providin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab7c9ac6f3d7bf78d18847b8283213
https://pubmed.ncbi.nlm.nih.gov/18602262
https://pubmed.ncbi.nlm.nih.gov/18602262
Autor:
Andy Blanchard, Steve Ludbrook, RG Jenkins, Jeni Luckett, Alan C. Perkins, Anthony Habgood, R Awas, John Marshall, Alison E. John
Publikováno v:
Thorax. 67:A33.2-A33
Introduction TGFβ activation by αvβ6 integrins is central to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Furthermore, αvβ6 expression is increased in both human, and murine, fibrotic lung tissue. Current assessment of αvβ6 integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3dcbcf5ee99eacf19f5250ce8c6903
https://doi.org/10.1136/thoraxjnl-2012-202678.072
https://doi.org/10.1136/thoraxjnl-2012-202678.072