Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steve Ledbetter"'
Autor:
Xiaoyan Liang, H William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter, Tomoko Hayashida
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155534 (2016)
Fibrosis is a final common pathway leading to loss of kidney function, in which the fibrogenic cytokine, transforming growth factor β (TGF-β), plays a central role. While previous studies showed that TGF-β antagonism by various means prevents fibr
Externí odkaz:
https://doaj.org/article/91d092167b4b44efb4ac8eb9b7aa49f7
Autor:
Hong Ling, Eric Roux, Donna Hempel, Jingzang Tao, Mandy Smith, Scott Lonning, Anna Zuk, Cynthia Arbeeny, Steve Ledbetter
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54499 (2013)
Considerable evidence has demonstrated that transforming growth factor β (TGF-β) plays a key role in hepatic fibrosis, the final common pathway for a variety of chronic liver diseases leading to liver insufficiency. Although a few studies have repo
Externí odkaz:
https://doaj.org/article/4b43228fd034496c847f8ab533e89eb5
Autor:
Michael Gershenovich, Anna Zuk, Christopher J. Chaber, Pan Du, Juanita Campos-Rivera, Meghan E. Clements, Steve Ledbetter, Mindy Zhang
Publikováno v:
Journal of the American Society of Nephrology. 27:159-170
Macrophages are a heterogeneous cell type implicated in injury, repair, and fibrosis after AKI, but the macrophage population associated with each phase is unclear. In this study, we used a renal bilateral ischemia-reperfusion injury mouse model to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daa71a6e979200f6838355117a717af
https://doi.org/10.1681/asn.2014111138
https://doi.org/10.1681/asn.2014111138
Autor:
Sara Conti, Masao Masui, G. Li Volti, Roger M. Mason, Giuseppe Remuzzi, Rossella Bianchi, Martin Petrucci, Marco Campana, Luigi Fabrizio Rodella, Masashi Ito, Ariela Benigni, Nadia Abdel Wahab, Shan Yan Lin, Diego Gazzolo, Hideki Tanioka, Roberto Motterlini, Steve Ledbetter, Daniela Corna, C. Di Giacomo, Yves Paquette, François A. Leblond, Elena Gagliardini, Hui Lin, Toshihiro Shinosaki, Alain Bonnardeaux, Daniela Rottoli, Xiang Ming Qi, Elisa Borsani, Yong Gui Wu, Guo Zhong Wu, Masashi Nishida, Rita Rezzani, Carla Zoja, Mitsuru Notoya, Vincent Pichette, Ji Jia Shen, Takayuki Kuroda, Fabio Sangalli, Kenji Hamaoka
Publikováno v:
Nephron Experimental Nephrology. 104:e185-e188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ac67c944e4fed572093116ffe019bf0
https://doi.org/10.1159/000097729
https://doi.org/10.1159/000097729
Autor:
Marcel Lebel, Mohsen Agharazii, Steve Ledbetter, Philippe Lavoie, Richard Larivière, Geneviève A. Robitaille
Publikováno v:
Journal of Hypertension. 23:1895-1903
We investigate the role of transforming growth factor-beta (TGF-beta) in hypertension and renal failure progression in uremic rats, and whether it modulates the endothelin (ET) system.Following renal mass reduction, uremic rats (Nx) received the pan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a682b0dde2cf27080c6cc86e0f652e
https://doi.org/10.1097/01.hjh.0000182521.44440.c5
https://doi.org/10.1097/01.hjh.0000182521.44440.c5
Publikováno v:
Kidney International. 65:106-115
Divergent effects of low versus high dose anti-TGF-β antibody in puromycin aminonucleoside nephropathy in rats.BackgroundTransforming growth factor-β (TGF-β) modulates immune/inflammatory cells, promotes extracellular matrix (ECM) accumulation, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29a06ca10319d98023e07094b131e4b
https://doi.org/10.1111/j.1523-1755.2004.00381.x
https://doi.org/10.1111/j.1523-1755.2004.00381.x
Publikováno v:
Cancer Chemotherapy and Pharmacology. 52:263-269
In an effort to study the importance of stromal involvement in angiogenesis, we developed a novel, multicellular model that utilizes three of the primary cell types involved in tumor angiogenesis.Fluorescently labeled human microvascular endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b85a95fb87ebd704538b6515d0cf5
https://doi.org/10.1007/s00280-003-0664-2
https://doi.org/10.1007/s00280-003-0664-2
Autor:
Richard D. Garman, John M. McPherson, Steve Ledbetter, Michael L. Hawes, Bruce Pratt, Melanie Ruzek, Susan M. Richards
Publikováno v:
Immunopharmacology and Immunotoxicology. 25:235-257
Mice genetically deficient in TGF-beta1 or TGF-beta signaling capacity in T or B cells demonstrate profound immune dysregulation, as evidenced by increased lymph node size, expression of markers of memory/activation on T cells, inflammation in a vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4218ee7ff1fa82e6e21e482bb776d4f
https://doi.org/10.1081/iph-120020473
https://doi.org/10.1081/iph-120020473
Autor:
Diane Felsen, Cathy Lawrence, Joshua M. Stern, Jie Chen, Sharda Jha, Akira Miyajima, Robert A. Soslow, Matthew L. Lemer, E. Darracott Vaughan, Steve Ledbetter, Dix P. Poppas, Joseph Pigato
Publikováno v:
Kidney International. 58:2301-2313
Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction. Background Unilateral ureteral obstruction (UUO) is characterized by progressive renal atrophy, renal interstitial fibrosis, an increase in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d08fa67af0496cbaa2d6ffa51a5ee6
https://doi.org/10.1046/j.1523-1755.2000.00414.x
https://doi.org/10.1046/j.1523-1755.2000.00414.x
Autor:
Scott Lonning, Mandy M. Smith, Cynthia Arbeeny, Hong Ling, Eric Roux, Steve Ledbetter, Anna Zuk, Donna M Hempel, Jingzang Tao
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54499 (2013)
PLoS ONE
PLoS ONE
Considerable evidence has demonstrated that transforming growth factor β (TGF-β) plays a key role in hepatic fibrosis, the final common pathway for a variety of chronic liver diseases leading to liver insufficiency. Although a few studies have repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d612862aefe798bab5b27749e8fab1
http://europepmc.org/articles/PMC3547926?pdf=render
http://europepmc.org/articles/PMC3547926?pdf=render