Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Steve Jean"'
Autor:
Benoît Marchand, Marc-Antoine Poulin, Christine Lawson, Lee-Hwa Tai, Steve Jean, Marie-Josée Boucher
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Gemcitabine is a first-line treatment agent for pancreatic ductal adenocarcinoma (PDAC). Contributing to its cytotoxicity, this chemotherapeutic agent is primarily a DNA replication inhibitor that also induces DNA damage. However, its therap
Externí odkaz:
https://doaj.org/article/7adc6cd57f9447d4acf4966c5bb05a53
Autor:
Annie Lauzier, Steve Jean
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 42-46 (2022)
Macroautophagy/autophagy is coupled to a myriad of intracellular processes, among which vesicular trafficking is an important contributor of membranes and proteins required at various stages, from autophagosome formation to degradation. Hence, unders
Externí odkaz:
https://doaj.org/article/75526264c7b24022bbfa0c0a237d20cb
Autor:
Clara Mancuso, Eric Tremblay, Elisa Gnodi, Steve Jean, Jean-François Beaulieu, Donatella Barisani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13040 (2023)
Metallic nanoparticles (mNPs) are widely used as food additives and can interact with gliadin triggering an immune response, but evaluation of the effects on crypts, hypertrophic in celiac subjects, is still lacking. This study evaluated the effects
Externí odkaz:
https://doaj.org/article/fcafd0296a48461997d564274837b866
Autor:
Steve Jean, Sonya Nassari
Publikováno v:
Contact, Vol 5 (2022)
Endosomes are a heterogeneous population of intracellular organelles responsible for sorting, recycling, or transporting internalized materials for degradation. Endosomal sorting and maturation are controlled by a complex interplay of regulators, wit
Externí odkaz:
https://doaj.org/article/f0ed23f626114f24b3607a90160ca8e9
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 99-119 (2020)
The next breakthrough for protein therapeutics is effective intracellular delivery and accumulation within target cells. Nuclear localization signal (NLS)-tagged therapeutics have been hindered by the lack of efficient nuclear localization due to end
Externí odkaz:
https://doaj.org/article/600849ef0c184a67a2bd45823a6dde3c
Publikováno v:
PLoS Genetics, Vol 18, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/cdbea4b6cfe34771b33b5aed84047af9
Autor:
Tomas Del Olmo, Camille Lacarrière-Keïta, Caroline Normandin, Dominique Jean, François-Michel Boisvert, Steve Jean
Publikováno v:
Biology Open, Vol 8, Iss 9 (2019)
Membrane trafficking controls vesicular transport of cargo between cellular compartments. Vesicular trafficking is essential for cellular homeostasis and dysfunctional trafficking is linked to several pathologies such as neurodegenerative diseases. F
Externí odkaz:
https://doaj.org/article/2fec6cd5c15448cb8657319313cf4fee
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008376 (2019)
Phosphoribosyl pyrophosphate synthetase (PRPS) is a rate-limiting enzyme whose function is important for the biosynthesis of purines, pyrimidines, and pyridines. Importantly, while missense mutations of PRPS1 have been identified in neurological diso
Externí odkaz:
https://doaj.org/article/7d475c845a66428895e4b3d9e1469429
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1064 (2020)
Rab GTPases play key roles in various cellular processes. They are essential, among other roles, to membrane trafficking and intracellular signaling events. Both trafficking and signaling events are crucial for proper embryonic development. Indeed, e
Externí odkaz:
https://doaj.org/article/3ca63765d6af440e92172eb114d34464
Autor:
Naonobu Fujita, Wilson Huang, Tzu-han Lin, Jean-Francois Groulx, Steve Jean, Jen Nguyen, Yoshihiko Kuchitsu, Ikuko Koyama-Honda, Noboru Mizushima, Mitsunori Fukuda, Amy A Kiger
Publikováno v:
eLife, Vol 6 (2017)
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throug
Externí odkaz:
https://doaj.org/article/1cacc78f0b644c31b7ecb37658e9d198