Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Steve J. Ballaron"'
Autor:
Stevan W. Djuric, Kennan C. Marsh, Gin C. Hsieh, Michael P. Sheets, Yung-Wu Chen, Thomas A. Fey, Cindy Henry, Karl W. Mollison, Rolf Wagner, Donna M. Gauvin, George W. Carter, James M. Trevillyan, Teresa A. Rosenberg, Sandra E. Burke, Steve J. Ballaron, Joy Bauch, Morey L. Smith
Publikováno v:
Journal of Cardiovascular Pharmacology. 49:228-235
Sirolimus (rapamycin) is an immunosuppressant used in preventing allograft rejection and in drug-eluting stents to prevent restenosis after angioplasty. Zotarolimus, an analogue of sirolimus, was designed to have a shorter in vivo half-life. Zotaroli
Autor:
James M. Trevillyan, Charles W. Hutchins, Thorsten Oost, Mike A. Stashko, Gang Liu, Tom Lubben, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Zhili Xin, Steve J. Ballaron, Philip J. Hajduk, Mike R Jirousek, Zhonghua Pei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1887-1890
—Wehavepreviouslyreportedanovelseriesofoxalyl-aryl-aminobenzoicacid-based,catalyticsite-directed,competitive,reversibleproteintyrosinephosphatase1B(PTP1B)inhibitors.Withreadilyaccesstokeyintermediates,weutilizedasolutionphaseparallelsynthesisapproa
Autor:
Bradley A. Zinker, Stephen W. Fesik, Bruce G. Szczepankiewicz, Charles W. Hutchins, Heng Liang, Cele Abad-Zapatero, David A. Janowick, Amanda K Mika, James M. Trevillyan, Mike A. Stashko, Zhonghua Pei, Steve J. Ballaron, Zhili Xin, Philip J. Hajduk, Michael R. Jirousek, Gang Liu, Tom Lubben
Publikováno v:
Journal of medicinal chemistry. 46(11)
Protein Tyrosine phosphatase 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling pathways. Using an NMR-based screening approach with 15N- and 13C-labeled PTP1B, we have identified 2,3-dimethylphenyloxalyla
Autor:
Stevan W. Djuric, Q. M. Tang, Steve J. Ballaron, C. B. Putman, K. W. Mollison, Morey L. Smith, X. G. Chiou, P. Wiedeman, E. J. Gubbins, H. T. Smith, Noah Tu, Yuanwei Chen, C. R. Faltynek, David J. Madar, Usha Warrior, A. Buko, J. M. Trevillyan, M. P. Sheets
Publikováno v:
Archives of biochemistry and biophysics. 364(1)
Lck encodes a 56-kDa protein-tyrosine kinase, predominantly expressed in T lymphocytes, crucial for initiating T cell antigen receptor (TCR) signal transduction pathways, culminating in T cell cytokine gene expression and effector functions. As a con