Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Steve J Webster"'
Autor:
Matthew J. Elder, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a
Externí odkaz:
https://doaj.org/article/d37c0112f5e9441b8aa4a1a774e80bea
Autor:
Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immuni
Externí odkaz:
https://doaj.org/article/7b61fa02b4424390890f997b33134bad
Autor:
Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz:
https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5
Autor:
Robert J. Pickering, Lee Hopkins, Panagiotis Tourlomousis, Joseph P. Boyle, James Rooney, Tom P. Monie, Søren Warming, Nobuhiko Kayagaki, Betsaida Bibo-Verdugo, Zsofia Digby, Steve J. Webster, Guy S. Salvesen, Clare E. Bryant, Lucy A. Weinert
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109614-(2021)
Cell Reports
Cell Reports
Summary Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df4b31528ec19572257040cf0ef6a0e
https://www.repository.cam.ac.uk/handle/1810/326412
https://www.repository.cam.ac.uk/handle/1810/326412
Autor:
Nathaniel L. Lam, Steve J. Webster, Lee M. Booty, Anna M. Gram, John A. Wright, Robert J. Pickering, Clare E. Bryant
Publikováno v:
The Journal of Immunology Author Choice
Key Points Salmonella infection leads to NAIP/NLRC4 and NLRP3 inflammasome activation. Flagellin activates the NAIP/NLRC4 and NLRP3 inflammasome in human macrophages. Flagellin mediates NLRP3 activation in a ROS- and/or cathepsin-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046d51b41f91fccd92ac5385a8ff69b2
https://www.repository.cam.ac.uk/handle/1810/314869
https://www.repository.cam.ac.uk/handle/1810/314869
Autor:
Zsofia Digby, Robert J. Pickering, Lee Hopkins, Nobuhiko Kayagaki, Joseph P. Boyle, Betsy Bibo Verdugo, Clare E. Bryant, Tom P. Monie, Søren Warming, James Rooney, Guy S. Salvesen, Steve J. Webster, Lucy A. Weinert
Publikováno v:
SSRN Electronic Journal.
Zoonotic infections, such as COVID-19, reside in animal hosts before jumping species to humans. The Carnivora, like mink, carry many zoonoses yet how diversity in host immune genes across species impact upon pathogen carriage are poorly understood. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f61c931a15281349b6753fbd4f8fad6
https://doi.org/10.2139/ssrn.3778331
https://doi.org/10.2139/ssrn.3778331
Autor:
Steve J. Webster, Lee Hopkins, Alessandra S Bittante, Duncan J. Maskell, John A. Wright, Clare E. Bryant, Panagiotis Tourlomousis, Owain J. Bryant, Pietro Mastroeni
Publikováno v:
Nat Microbiol
Pattern recognition receptors (PRRs) expressed in antigen-presenting cells are thought to shape pathogen-specific immunity by inducing secretion of co-stimulatory cytokines during T-cell activation, yet data to support this notion in vivo is surprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3065850fc7b499f509944d89b2a646
Autor:
Jane C. Goodall, Steve J. Webster
Publikováno v:
Microbes and infection. 20(7-8)
Since the concept of the inflammasome was introduced by Martinon, Burns and Tschopp in 2002, there has been an exponential increase in our understanding of how inflammasomes (caspase activating molecular platforms) regulate innate inflammatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f21668a255af335954daef2cef86e1
https://pubmed.ncbi.nlm.nih.gov/29248634
https://pubmed.ncbi.nlm.nih.gov/29248634
Autor:
Steve J. Webster, Averil Y. Warren, Raheela N. Khan, Neil Chapman, Saurabh V. Gandhi, Sarah L. Waite, G. Nicholas Europe-Finner, Victoria J. Cookson
Publikováno v:
Journal of Biological Chemistry. 288:6704-6716
The onset of parturition is associated with a number of proinflammatory mediators that are themselves regulated by the nuclear factor κB (NF-κB) family of transcription factors. In this context, we previously reported that the RelA NF-κB subunit r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd0fa1f8d75f961657e5da353be82cd7
https://doi.org/10.1074/jbc.m112.440602
https://doi.org/10.1074/jbc.m112.440602
Autor:
Steve J, Webster, Sven, Brode, Lou, Ellis, Timothy J, Fitzmaurice, Matthew J, Elder, Nelson O, Gekara, Panagiotis, Tourlomousis, Clare, Bryant, Simon, Clare, Ronnie, Chee, Hill J S, Gaston, Jane C, Goodall
Publikováno v:
PLoS Pathogens
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d607aaade192086e743ae6844fad9ce
https://pubmed.ncbi.nlm.nih.gov/28570638
https://pubmed.ncbi.nlm.nih.gov/28570638