Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Steve J, Bertolani"'
Publikováno v:
ACS Omega, Vol 4, Iss 27, Pp 22356-22362 (2019)
Externí odkaz:
https://doaj.org/article/b27e91eddb4341b4b895b7d46259f7a1
Autor:
Steve J Bertolani, Justin B Siegel
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214126 (2019)
Enzymes play a critical role in a wide array of industrial, medical, and research applications and with the recent explosion of genomic sequencing, we now have sequences for millions of enzymes for which there is no known structure. In order to utili
Externí odkaz:
https://doaj.org/article/31b3aa34ed5e49f9bb4d96de16ee9797
Autor:
David K. Wilson, Wai Shun Mak, Ilias Tagkopoulos, Youtian Cui, Rigoberto Arenas, Steve J. Bertolani, Justin B. Siegel, Xiaokang Wang, Wen Qiao Deng
Publikováno v:
Biochemistry. 59(40)
To complement established rational and evolutionary protein design approaches, significant efforts are being made to utilize computational modeling and the diversity of naturally occurring protein sequences. Here, we combine structural biology, genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2b59a106634237c459d3ac97597edf
https://pubmed.ncbi.nlm.nih.gov/32935984
https://pubmed.ncbi.nlm.nih.gov/32935984
Autor:
Jon D. Wright, Sheila S. David, C. Satheesan Babu, Jeremy A. Armas, Jensen M. Spear, Nicole N. Nuñez, Carmay Lim, Anisha N. Rajavel, Justin B. Siegel, Steve J. Bertolani, Cindy Khuu
Publikováno v:
Journal of the American Chemical Society. 140:13260-13271
The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8-oxoguanine (8-oxoG):A mismatches. The importance of this mutation suppression activity in tumor suppressor ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e5e474f1d1a4f641c803c7772761e1
https://doi.org/10.1021/jacs.8b06923
https://doi.org/10.1021/jacs.8b06923
Autor:
Nicole N, Nuñez, Cindy, Khuu, C Satheesan, Babu, Steve J, Bertolani, Anisha N, Rajavel, Jensen E, Spear, Jeremy A, Armas, Jon D, Wright, Justin B, Siegel, Carmay, Lim, Sheila S, David
Publikováno v:
Journal of the American Chemical Society. 140(41)
The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8-oxoguanine (8-oxoG):A mismatches. The importance of this mutation suppression activity in tumor suppressor ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f63442326cd9e6cba7f70fb1ef2aaaf
https://pubmed.ncbi.nlm.nih.gov/30208271
https://pubmed.ncbi.nlm.nih.gov/30208271
Publikováno v:
Chemical science, vol 7, iss 7
Chemical Science
Chemical Science
Predicting the binding mode of carbocations produced in sesquiterpene synthase enzymes is not unlike finding a piece of hay in a haystack. A new method for tackling this problem is described.
Sesquiterpenoids comprise a class of terpenoid natura
Sesquiterpenoids comprise a class of terpenoid natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85cc2b69d1490b593347c38f364b1c1
https://escholarship.org/uc/item/952044c9
https://escholarship.org/uc/item/952044c9
Publikováno v:
Methods in Molecular Biology ISBN: 9781493935673
Recently, there have been several successful cases of introducing catalytic activity into proteins. One method that has been used successfully to achieve this is the theozyme placement and enzyme design algorithms implemented in Rosetta Molecular Mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a944999559176c1438e2739665ce8ff
https://doi.org/10.1007/978-1-4939-3569-7_13
https://doi.org/10.1007/978-1-4939-3569-7_13
Autor:
David Baker, Ryan J. Marcheschi, James C. Liao, Wai Shun Mak, Stephen Tran, James Thompson, Steve J. Bertolani, Justin B. Siegel
Publikováno v:
Nature communications, vol 6, iss 1
Nature Communications
Nature Communications
The ability to biosynthetically produce chemicals beyond what is commonly found in Nature requires the discovery of novel enzyme function. Here we utilize two approaches to discover enzymes that enable specific production of longer-chain (C5–C8) al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c067d96fb8b090128e9e5bc929d01a79
https://doi.org/10.1038/ncomms10005
https://doi.org/10.1038/ncomms10005
Publikováno v:
Chemical communications (Cambridge, England). 51(12)
Mutants of toluene o-xylene monooxygenase are demonstrated to oxidize ethylene to ethylene oxide in vivo at yields of >99%. The best mutant increases ethylene oxidation activity by >5500-fold relative to the native enzyme. This is the first report of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3677bd51ecef6ae2d84f739f11f46ef3
https://pubmed.ncbi.nlm.nih.gov/25558486
https://pubmed.ncbi.nlm.nih.gov/25558486
Autor:
Ryan J. Marcheschi, Steve J. Bertolani, David Baker, Justin B. Siegel, Stephen Tran, Wai Shun Mak, James Thompson, James C. Liao
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 6: Article number: 10005 (2015); Published: 24 November 2015; Updated: 7 June 2016 In the original version of this Article the chemical structures of 2-ketoisovaleric acid and isobutanal in Fig. 3a were incorrect. The correct ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d707f68401268d163513ece179ed2ab
https://doaj.org/article/e3971b4c9be3437ead3b3a937f91d0ad
https://doaj.org/article/e3971b4c9be3437ead3b3a937f91d0ad