Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Steve Hume"'
Autor:
Kelsi Swope, Josh Morton, Gregory P. Pogue, Leigh Burden, Nicholas Partain, Steve Hume, John Shepherd, Carrie A. Simpson, Miles B. Brennan, Thomas C. Furman, Sheila Kingrey-Gebe, Theresa Martinez, Jim McDonough, Michael H. Pauly, Kevin J. Whaley, Larry Zeitlin, Barry Bratcher, Hugh Haydon
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The ongoing SARS-CoV-2 coronavirus pandemic of 2020–2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb) therapies. As reported here, a platform based on Nicotiana benthamiana produced mAb therape
Externí odkaz:
https://doaj.org/article/0444f122130744d095e196c092b78bd8
Autor:
Jennifer K. DeMarco, Joshua M. Royal, William E. Severson, Jon D. Gabbard, Steve Hume, Josh Morton, Kelsi Swope, Carrie A. Simpson, John W. Shepherd, Barry Bratcher, Kenneth E. Palmer, Gregory P. Pogue
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1346 (2021)
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain. CoV-RBD121-NP elicits
Externí odkaz:
https://doaj.org/article/d948abd924354895b2c5b1c46d082bd9
Autor:
Joshua M. Royal, Carrie A. Simpson, Alison A. McCormick, Amanda Phillips, Steve Hume, Josh Morton, John Shepherd, Youngjun Oh, Kelsi Swope, Jennifer L. DeBeauchamp, Richard J. Webby, Robert W. Cross, Viktoriya Borisevich, Thomas W. Geisbert, Jennifer K. Demarco, Barry Bratcher, Hugh Haydon, Gregory P. Pogue
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1347 (2021)
Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (
Externí odkaz:
https://doaj.org/article/43b61c27594a4cee8b9a7611a625c5e8
Autor:
Tsepo Lebiletsa Tsekoa, Therese Lotter-Stark, Sindisiwe Buthelezi, Ereck Chakauya, Stoyan H Stoychev, Claude Sabeta, Wonderful Shumba, Baby Phahladira, Steve Hume, Josh Morton, Charles E Rupprecht, Herta Steinkellner, Michael Pauly, Larry Zeitlin, Kevin Whaley, Rachel Chikwamba
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159313 (2016)
Rabies is a neglected zoonotic disease that has no effective treatment after onset of illness. However the disease can be prevented effectively by prompt administration of post exposure prophylaxis which includes administration of passive immunizing
Externí odkaz:
https://doaj.org/article/15078b4d36a44f1c8c99a86de7f30e3c
Autor:
Kelsi, Swope, Josh, Morton, Gregory P, Pogue, Steve, Hume, Michael H, Pauly, John, Shepherd, Carrie A, Simpson, Barry, Bratcher, Kevin J, Whaley, Larry, Zeitlin, Keith R, Davis, Hugh, Haydon
Publikováno v:
Methods in enzymology. 660
Monoclonal antibodies (mAbs) hold great promise for treating diseases ranging from cancer to infectious disease. Manufacture of mAbs is challenging, expensive, and time-consuming using mammalian systems. We describe detailed methods used by Kentucky
Autor:
Gregory P. Pogue, Steve Hume, Jennifer K. DeMarco, Josh Morton, John W. Shepherd, Jon D. Gabbard, Joshua M. Royal, Kelsi Swope, Barry Bratcher, Kenneth E. Palmer, William Severson, Carrie A. Simpson
Publikováno v:
Vaccines
Vaccines, Vol 9, Iss 1346, p 1346 (2021)
Volume 9
Issue 11
Vaccines, Vol 9, Iss 1346, p 1346 (2021)
Volume 9
Issue 11
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain. CoV-RBD121-NP elicits
Autor:
Kevin J. Whaley, Barry Bratcher, Hugh Haydon, Carrie A. Simpson, Josh Morton, Keith R. Davis, Gregory P. Pogue, Michael H. Pauly, Steve Hume, Kelsi Swope, Larry Zeitlin, John W. Shepherd
Publikováno v:
Methods in Enzymology ISBN: 9780323907378
Monoclonal antibodies (mAbs) hold great promise for treating diseases ranging from cancer to infectious disease. Manufacture of mAbs is challenging, expensive, and time-consuming using mammalian systems. We describe detailed methods used by Kentucky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aecff14492cc9515dbb7d65a83a54b4
https://doi.org/10.1016/bs.mie.2021.05.011
https://doi.org/10.1016/bs.mie.2021.05.011
Autor:
Hugh Haydon, Amanda Phillips, Gregory P. Pogue, Robert W. Cross, Steve Hume, Joshua M. Royal, Jennifer DeBeauchamp, Thomas W. Geisbert, Josh Morton, Alison A. McCormick, John W. Shepherd, Carrie A. Simpson, Viktoriya Borisevich, Barry Bratcher, Jennifer K. DeMarco, Richard J. Webby, Kelsi Swope, Young Jun Oh
Publikováno v:
Vaccines, Vol 9, Iss 1347, p 1347 (2021)
Vaccines
Volume 9
Issue 11
Vaccines
Volume 9
Issue 11
Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (
Autor:
Hugh Haydon, Richard J. Webby, Alison A. McCormick, Rachel Chikwamba, Trushar Jeevan, Ernie Hiatt, Barry Bratcher, Gregory P. Pogue, Steve Hume, Jyothi K. Mallajosyula, Ashley K. Johnson
Publikováno v:
Human Vaccines & Immunotherapeutics. 10:586-595
Recombinant subunit vaccines are an efficient strategy to meet the demands of a possible influenza pandemic, because of rapid and scalable production. However, vaccines made from recombinant hemagglutinin (HA) subunit protein are often of low potency
Autor:
Baby Phahladira, Charles E. Rupprecht, Herta Steinkellner, Michael H. Pauly, Tsepo L. Tsekoa, Steve Hume, Claude T. Sabeta, Josh Morton, Larry Zeitlin, Kevin J. Whaley, Ereck Chakauya, Wonderful Shumba, Stoyan Stoychev, Therese Lotter-Stark, Rachel Chikwamba, Sindisiwe G. Buthelezi
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159313 (2016)
PLoS ONE
PLoS ONE
Rabies is a neglected zoonotic disease that has no effective treatment after onset of illness. However the disease can be prevented effectively by prompt administration of post exposure prophylaxis which includes administration of passive immunizing