Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Steve Horrigan"'
Autor:
Christopher P. Mill, Kapil N. Bhalla, Christine Birdwell, Warren Fiskus, Steve Horrigan, Koichi Takahashi, Courtney D. DiNardo, Arnold Salazar, Tapan M. Kadia, John A. Davis
Publikováno v:
Blood. 138:3349-3349
EVI1 gene maps to the MECOM locus at chromosome 3q26.2 and encodes for a zinc finger domain-containing transcriptional regulator. EVI1 supports hematopoietic stem cell self-renewal and blocks hematopoietic differentiation. EVI1 is overexpressed in up
Autor:
Srdan Verstovsek, Steve Horrigan, Christopher P. Mill, Sunil Sharma, Steven M. Kornblau, Craig M. Crews, Taghi Manshouri, Baohua Sun, Kapil N. Bhalla, Prithviraj Bose, Agnieszka J Nowak, Tapan M. Kadia, Peng Qiu, Kimal Rajapakshe, Raffaella Soldi, David N. Saenz, Gautam Borthakur, Warren Fiskus, Dyana T. Saenz, Kanak Raina, Cristian Coarfa, Lucia Masarova, Joseph D. Khoury, Yimin Qian
Publikováno v:
Leukemia. 33(6)
Transformation of post-myeloproliferative neoplasms into secondary (s) AML exhibit poor clinical outcome. In addition to increased JAK-STAT and PI3K-AKT signaling, post-MPN sAML blast progenitor cells (BPCs) demonstrate increased nuclear β-catenin l
Autor:
Christopher P. Mill, Steve Horrigan, Sunil Sharma, Dyana T. Saenz, Joseph D. Khoury, Kapil N. Bhalla, Raffaella Soldi, Warren Fiskus, Srdan Verstovesek, Taghi Manshouri
Publikováno v:
Cancer Research. 79:3036-3036
Treatment with bromodomain and extra-terminal protein inhibitor (BETi) reduces in vivo AML cell burden, inducing clinical remissions in AML. Yet, resistance to BETi treatment develops uniformly. Here, following at least 10 exposures of secondary (s)
Autor:
Bo Chen, Ricardo Cibotti, Qin Zong, Chad Morris, Juana Castaneda, Brian Naiman, Derong Liu, Anna Glodek, Dan Soppet, Steve Horrigan, Peter Kiener, Anthony Coyle, Laurent Audoly
Publikováno v:
The Journal of Immunology. 178:S240-S240
Multiple lines of evidence suggest that inhibition of Type I Interferons (IFNs), including IFN(, may provide a therapeutic benefit in treating a number of autoimmune diseases such as Systemic Lupus Erythematosus (SLE). Herein, we describe the generat