Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Steve Goodison"'
Autor:
Hideki Furuya, Yuka Sasaki, Runpu Chen, Rafael Peres, Kanani Hokutan, Kaoru Murakami, Nari Kim, Owen T. M. Chan, Ian Pagano, Lars Dyrskjøt, Jørgen B. Jensen, Per-Uno Malmstrom, Ulrika Segersten, Yijun Sun, Abolfazl Arab, Hani Goodarzi, Steve Goodison, Charles J. Rosser
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator, impacting fibrinolysis. Recent studies have revealed
Externí odkaz:
https://doaj.org/article/1552f505b3f3484bb224cce583c25fb3
Autor:
Lu Li, Jiho Sohn, Robert J Genco, Jean Wactawski-Wende, Steve Goodison, Patricia I Diaz, Yijun Sun
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010373 (2022)
A microbial community is a dynamic system undergoing constant change in response to internal and external stimuli. These changes can have significant implications for human health. However, due to the difficulty in obtaining longitudinal samples, the
Externí odkaz:
https://doaj.org/article/e0f7c8d825314dde98b0f0a31e1a91e1
Autor:
Yosuke Hirasawa, Ian Pagano, Runpu Chen, Yijun Sun, Yunfeng Dai, Amit Gupta, Sergei Tikhonenkov, Steve Goodison, Charles J. Rosser, Hideki Furuya
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease has the potential to ad
Externí odkaz:
https://doaj.org/article/74fa989e3a7d4146a10ac40cfcc7000f
Autor:
Runpu Chen, Ian Pagano, Yijun Sun, Kaoru Murakami, Steve Goodison, Ramanathan Vairavan, Malak Tahsin, Peter C. Black, Charles J. Rosser, Hideki Furuya
Publikováno v:
Diagnostics, Vol 12, Iss 8, p 1801 (2022)
Bladder cancer is a biologically heterogeneous disease with variable clinical presentations, outcomes and responses to therapy. Thus, the clinical utility of single biomarkers for the detection and prediction of biological behavior of bladder cancer
Externí odkaz:
https://doaj.org/article/dd534a562a404d6aa7e6b3f7faebb511
Autor:
Kaoru Murakami, Ian Pagano, Runpu Chen, Yijun Sun, Steve Goodison, Charles J. Rosser, Hideki Furuya
Publikováno v:
Diagnostics, Vol 11, Iss 6, p 1023 (2021)
Background: The Oncuria™ urine test for the detection of bladder cancer measures a multiplex protein signature. In this study, we investigated the influence of urinary cellularity, protein, and hematuria on the performance of the Oncuria™ test in
Externí odkaz:
https://doaj.org/article/6c6c89f3b99142e99f38c79f8b019477
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Scientists have discovered various prognostic gene signatures (GSs) in different cancer types. Surprisingly, although different GSs from the same cancer type can be used to measure similar biological characteristics, often rarely is there a
Externí odkaz:
https://doaj.org/article/315dc1b7105b4ddcb1b20231b1318e53
Publikováno v:
European Medical Journal Urology, Vol 1, Iss 1, Pp 70-73 (2013)
The development of accurate and reliable molecular assays that could diagnose bladder cancer would be of significant benefit to both patients and the healthcare system. Non-invasive assays that have utility not only for diagnosis, but also for monito
Externí odkaz:
https://doaj.org/article/f26c877e0d7240059e91b4ecbae48320
Autor:
Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O Egan, Peter R Rhode, Alexander S Parker, Karl X Chai, Hing C Wong, Charles J Rosser
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e96705 (2014)
Intravesical Bacillus Calmette-Guérin (BCG) has been shown to induce a specific immunologic response (i.e., activation of IL-2 and effector T-cells), while preclinical studies using ALT-803 (mutated IL-15 analogue combined with IL-15Rα-Fc fusion) h
Externí odkaz:
https://doaj.org/article/7d8e08cbabb346929eb7f54dd951ae87
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47469 (2012)
Accurate urinary assays for bladder cancer (BCa) detection would benefit both patients and healthcare systems. Through genomic and proteomic profiling of urine components, we have previously identified a panel of biomarkers that can outperform curren
Externí odkaz:
https://doaj.org/article/35f0b3a71b1a424ea2badd3ac1cbfee0
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37797 (2012)
The early detection of bladder cancer (BCa) is pivotal for successful patient treatment and management. Through genomic and proteomic studies, we have identified a number of bladder cancer-associated biomarkers that have potential clinical utility. I
Externí odkaz:
https://doaj.org/article/80e2d795c8b6494087cfa41cc638f706