Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Steve Gamble"'
Autor:
Andrea L. Richardson, Anne Lise Børresen-Dale, Christos Sotiriou, Benita Kiat Tee Bk Tan, Laura Van't Veer, Andrew Tutt, Mia Petljak, David C. Wedge, Michael R. Stratton, Ludmil B. Alexandrov, Carlos Caldas, Åke Borg, Raheleh Rahbari, Inigo Martincorena, Alastair M Thompson, Henk Stunnenberg, Sancha Martin, Stian Knappskog, Marc J. van de Vijver, John W.M. Martens, Colin A. Purdie, Nikita Patel, Sarah O’Meara, Naoto T. Ueno, Peter J. Campbell, Matthew Me Hurles, Christopher Alder, Paul N. Span, Jorunn E. Eyfjord, Torril Sauer, Manasa Ramakrishna, Anthony Fullam, Steve Gamble, Helen Davies, S. Pinder, Alain Viari, Dilip Giri, Serena Nik-Zainal, Young Seok Ju, Moritz Gerstung, Sunil R. Lakhani
Publikováno v:
Nature, 543(7647), 714-+. Nature Publishing Group
Nature
Nature, 2017, 543 (7647), pp.714-718. ⟨10.1038/nature21703⟩
Ju, Y S, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, L B, Rahbari, R, Wedge, D C, Davies, H R, Ramakrishna, M, Fullam, A, Martin, S, Alder, C, Patel, N, Gamble, S, O'Meara, S, Giri, D D, Sauer, T, Pinder, S E, Purdie, C A, Borg, Å, Stunnenberg, H, Van De Vijver, M, Tan, B K T, Caldas, C, Tutt, A, Ueno, N T, Van 'T Veer, L J, Martens, J W M, Sotiriou, C, Knappskog, S, Span, P N, Lakhani, S R, Eyfjörd, J E, Børresen-Dale, A-L, Richardson, A, Thompson, A M, Viari, A, Hurles, M E, Nik-Zainal, S, Campbell, P J & Stratton, M R 2017, ' Somatic mutations reveal asymmetric cellular dynamics in the early human embryo ', Nature . https://doi.org/10.1038/nature21703
Ju, Y S, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, L B, Rahbari, R, Wedge, D C, Davies, H R, Ramakrishna, M, Fullam, A, Martin, S, Alder, C, Patel, N, Gamble, S, O'Meara, S, Giri, D D, Sauer, T, Pinder, S E, Purdie, C A, Borg, Å, Stunnenberg, H, van de Vijver, M, Tan, B K T, Caldas, C, Tutt, A, Ueno, N T, van 't Veer, L J, Martens, J W M, Sotiriou, C, Knappskog, S, Span, P N, Lakhani, S R, Eyfjörd, J E, Børresen-Dale, A-L, Richardson, A, Thompson, A M, Viari, A, Hurles, M E, Nik-Zainal, S, Campbell, P J & Stratton, M R 2017, ' Somatic mutations reveal asymmetric cellular dynamics in the early human embryo ', Nature, vol. 543, no. 7647, pp. 714-718 . https://doi.org/10.1038/nature21703
Nature, Nature Publishing Group, 2017, 543 (7647), pp.714-718. ⟨10.1038/nature21703⟩
Nature, 543, 714-718
Nature, 543, 7647, pp. 714-718
Nature, vol 543, iss 7647
Nature, 543(7647), 714-718. Nature Publishing Group
Nature
Nature, 2017, 543 (7647), pp.714-718. ⟨10.1038/nature21703⟩
Ju, Y S, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, L B, Rahbari, R, Wedge, D C, Davies, H R, Ramakrishna, M, Fullam, A, Martin, S, Alder, C, Patel, N, Gamble, S, O'Meara, S, Giri, D D, Sauer, T, Pinder, S E, Purdie, C A, Borg, Å, Stunnenberg, H, Van De Vijver, M, Tan, B K T, Caldas, C, Tutt, A, Ueno, N T, Van 'T Veer, L J, Martens, J W M, Sotiriou, C, Knappskog, S, Span, P N, Lakhani, S R, Eyfjörd, J E, Børresen-Dale, A-L, Richardson, A, Thompson, A M, Viari, A, Hurles, M E, Nik-Zainal, S, Campbell, P J & Stratton, M R 2017, ' Somatic mutations reveal asymmetric cellular dynamics in the early human embryo ', Nature . https://doi.org/10.1038/nature21703
Ju, Y S, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, L B, Rahbari, R, Wedge, D C, Davies, H R, Ramakrishna, M, Fullam, A, Martin, S, Alder, C, Patel, N, Gamble, S, O'Meara, S, Giri, D D, Sauer, T, Pinder, S E, Purdie, C A, Borg, Å, Stunnenberg, H, van de Vijver, M, Tan, B K T, Caldas, C, Tutt, A, Ueno, N T, van 't Veer, L J, Martens, J W M, Sotiriou, C, Knappskog, S, Span, P N, Lakhani, S R, Eyfjörd, J E, Børresen-Dale, A-L, Richardson, A, Thompson, A M, Viari, A, Hurles, M E, Nik-Zainal, S, Campbell, P J & Stratton, M R 2017, ' Somatic mutations reveal asymmetric cellular dynamics in the early human embryo ', Nature, vol. 543, no. 7647, pp. 714-718 . https://doi.org/10.1038/nature21703
Nature, Nature Publishing Group, 2017, 543 (7647), pp.714-718. ⟨10.1038/nature21703⟩
Nature, 543, 714-718
Nature, 543, 7647, pp. 714-718
Nature, vol 543, iss 7647
Nature, 543(7647), 714-718. Nature Publishing Group
International audience; Somatic cells acquire mutations throughout the course of an individual's life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1c497d74a34958743de54ad1d0830b
https://pure.eur.nl/en/publications/8bc44218-2041-4ab7-9f32-e310b94028b1
https://pure.eur.nl/en/publications/8bc44218-2041-4ab7-9f32-e310b94028b1
Autor:
Jiqiu Cheng, Laura Mudie, Stuart McLaren, Adam Shlien, Amy Capper, David T. Jones, Sarah O’Meara, Derek L. Stemple, Jennifer Yen, David J. Adams, Alison M. Taylor, Steve Gamble, Ian R. Watson, Jennifer Richardson, Leonard I. Zon, Manasa Ramakrishna, E. Elizabeth Patton, David C. Wedge, Peter J. Campbell, Mike Dovey, James A. Lister, Lynda Chin, Chang-Jiun Wu, Richard M. White, John Marshall, Keiran Raine, Charles K. Kaufman, Patrick S. Tarpey, Serena Nik-Zainal, Yves Moreau, P. Andy Futreal, Inigo Martincorena, Ian Whitmore, Calli Latimer, Erin M Langdon, Adam Butler, Jon W. Teague, Peter Van Loo, Andy Menzies, Jeroen de Ridder
Publikováno v:
Genome Biology
Genome Biology, 14, 2013
Yen, J, White, R M, Wedge, D C, Van Loo, P, de Ridder, J, Capper, A, Richardson, J, Jones, D, Raine, K, Watson, I R, Wu, C-J, Cheng, J, Martincorena, I, Nik-Zainal, S, Mudie, L, Moreau, Y, Marshall, J, Ramakrishna, M, Tarpey, P, Shlien, A, Whitmore, I, Gamble, S, Latimer, C, Langdon, E, Kaufman, C, Dovey, M, Taylor, A, Menzies, A, McLaren, S, O Meara, S, Butler, A, Teague, J, Lister, J, Chin, L, Campbell, P, Adams, D J, Zon, L I, Patton, E E, Stemple, D L & Futreal, P A 2013, ' The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models ', Genome Biology, vol. 14, no. 10, R113 . https://doi.org/10.1186/gb-2013-14-10-r113
Genome Biology, 14, 2013
Yen, J, White, R M, Wedge, D C, Van Loo, P, de Ridder, J, Capper, A, Richardson, J, Jones, D, Raine, K, Watson, I R, Wu, C-J, Cheng, J, Martincorena, I, Nik-Zainal, S, Mudie, L, Moreau, Y, Marshall, J, Ramakrishna, M, Tarpey, P, Shlien, A, Whitmore, I, Gamble, S, Latimer, C, Langdon, E, Kaufman, C, Dovey, M, Taylor, A, Menzies, A, McLaren, S, O Meara, S, Butler, A, Teague, J, Lister, J, Chin, L, Campbell, P, Adams, D J, Zon, L I, Patton, E E, Stemple, D L & Futreal, P A 2013, ' The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models ', Genome Biology, vol. 14, no. 10, R113 . https://doi.org/10.1186/gb-2013-14-10-r113
Background: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53