Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Steve Eyre"'
Autor:
Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the fin
Externí odkaz:
https://doaj.org/article/fc874bf79d974ecf8ffc27cc8532e984
Autor:
Dorothée Diogo, Lisa Bastarache, Katherine P Liao, Robert R Graham, Robert S Fulton, Jeffrey D Greenberg, Steve Eyre, John Bowes, Jing Cui, Annette Lee, Dimitrios A Pappas, Joel M Kremer, Anne Barton, Marieke J H Coenen, Barbara Franke, Lambertus A Kiemeney, Xavier Mariette, Corrine Richard-Miceli, Helena Canhão, João E Fonseca, Niek de Vries, Paul P Tak, J Bart A Crusius, Michael T Nurmohamed, Fina Kurreeman, Ted R Mikuls, Yukinori Okada, Eli A Stahl, David E Larson, Tracie L Deluca, Michelle O'Laughlin, Catrina C Fronick, Lucinda L Fulton, Roman Kosoy, Michael Ransom, Tushar R Bhangale, Ward Ortmann, Andrew Cagan, Vivian Gainer, Elizabeth W Karlson, Isaac Kohane, Shawn N Murphy, Javier Martin, Alexandra Zhernakova, Lars Klareskog, Leonid Padyukov, Jane Worthington, Elaine R Mardis, Michael F Seldin, Peter K Gregersen, Timothy Behrens, Soumya Raychaudhuri, Joshua C Denny, Robert M Plenge
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122271 (2015)
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to inte
Externí odkaz:
https://doaj.org/article/beb6d79c3e184701a89299ca92e0df4f
Autor:
Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L De Jager, Katherine A Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A Clemons, Eli Stahl, Nicola Tolliday, Robert M Plenge
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003487 (2013)
Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. Here, we sought to understand t
Externí odkaz:
https://doaj.org/article/603abdaa6bb84998953d03c9d0b32fa5
Autor:
Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, Samuela Pollack, Anne Barton, Heike Bickeböller, Donald W Bowden, Steve Eyre, Barry I Freedman, David J Friedman, John K Field, Leif Groop, Aage Haugen, Joachim Heinrich, Brian E Henderson, Pamela J Hicks, Lynne J Hocking, Laurence N Kolonel, Maria Teresa Landi, Carl D Langefeld, Loic Le Marchand, Michael Meister, Ann W Morgan, Olaide Y Raji, Angela Risch, Albert Rosenberger, David Scherf, Sophia Steer, Martin Walshaw, Kevin M Waters, Anthony G Wilson, Paul Wordsworth, Shanbeh Zienolddiny, Eric Tchetgen Tchetgen, Christopher Haiman, David J Hunter, Robert M Plenge, Jane Worthington, David C Christiani, Debra A Schaumberg, Daniel I Chasman, David Altshuler, Benjamin Voight, Peter Kraft, Nick Patterson, Alkes L Price
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003032 (2012)
Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, in type 2 diabetes, odds r
Externí odkaz:
https://doaj.org/article/708d0c6242ad40ada417d4c7a6f43814
Autor:
Ali Al-Janabi, Steve Eyre, Amy C. Foulkes, Adnan R. Khan, Nick Dand, Ekaterina Burova, Bernadette DeSilva, Areti Makrygeorgou, Emily Davies, Catherine H. Smith, Christopher E.M. Griffiths, Andrew P. Morris, Richard B. Warren
Publikováno v:
Journal of Investigative Dermatology.
Autor:
Katherine V Sadler, John Bowes, Charlie F Rowlands, Cristina Perez-Becerril, C Mwee van der Meer, Andrew T King, Scott A Rutherford, Omar N Pathmanaban, Charlotte Hammerbeck-Ward, Simon K W Lloyd, Simon R Freeman, Ricky Williams, Cathal John Hannan, Daniel Lewis, Steve Eyre, D Gareth Evans, Miriam J Smith
Publikováno v:
Sadler, K, Bowes, J, Rowlands, C, Perez-Becerril, C, van der Meer, C M, King, A T, Rutherford, S A, Pathmanaban, O, Hammerbeck-ward, C, Lloyd, S K W, Freeman, S, Williams, R, Hannan, C J, Lewis, D, Eyre, S, Evans, D G & Smith, M J 2022, ' Genome-wide association analysis identifies a susceptibility locus for sporadic vestibular schwannoma at 9p21 ', Brain. https://doi.org/10.1093/brain/awac478
Vestibular schwannomas are benign nerve sheath tumours that arise on the vestibulocochlear nerves. Vestibular schwannomas are known to occur in the context of tumour predisposition syndromes NF2-related and LZTR1-related schwannomatosis. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e6e7c9057bbb14c32811fc35e8e63c
https://uom.elsevierpure.com/en/publications/79199585-efc4-4ec3-bcac-4c50a72be735
https://uom.elsevierpure.com/en/publications/79199585-efc4-4ec3-bcac-4c50a72be735
Autor:
Richard Warren, Andrew Morris, Christopher Griffiths, Catherine Smith, Nick Dand, Adnan Khan, Amy Foulkes, Steve Eyre, Ali Al-Janabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6103a69b670741e61d8f6c6bfc9a6fe1
https://doi.org/10.26226/m.62fa0098ba67fd001a9a0931
https://doi.org/10.26226/m.62fa0098ba67fd001a9a0931
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Ding, J, Smith, S, Orozco, G, Barton, A, Eyre, S & Martin, P 2020, ' Characterisation of CD4+ T-cell subtypes using single cell RNA sequencing and the impact of cell number and sequencing depth ', Scientific Reports, vol. 10, no. 1, 19825 . https://doi.org/10.1038/s41598-020-76972-9
Scientific Reports
Ding, J, Smith, S, Orozco, G, Barton, A, Eyre, S & Martin, P 2020, ' Characterisation of CD4+ T-cell subtypes using single cell RNA sequencing and the impact of cell number and sequencing depth ', Scientific Reports, vol. 10, no. 1, 19825 . https://doi.org/10.1038/s41598-020-76972-9
Scientific Reports
CD4+ T-cells represent a heterogeneous collection of specialised sub-types and are a key cell type in the pathogenesis of many diseases due to their role in the adaptive immune system. By investigating CD4+ T-cells at the single cell level, using RNA
Autor:
Steve Eyre, Magnus Rattray, Peyman Zarrineh, Antony Adamson, Paul Martin, Jing Yang, Peter Fraser, Xiangyu Ge, Andrew P. Morris, Kate Duffus, Amanda McGovern
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory
Autor:
Arthur G. Pratt, Louise N. Reynard, Ellis Niemantsverdriet, Ben Hargreaves, Nisha Nair, Kieran Murray, Najib Naamane, Anne Barton, Alexander D. Clark, Steve Eyre, Nishanthi Thalayasingam, Annette H M van der Helm-van Mil
Publikováno v:
Rheumatology. 60
Background/Aims Early diagnosis and intervention improves outcomes of immune mediated rheumatic and musculoskeletal diseases (RMDs) but may be hampered by diagnostic uncertainty. The extent to which rationally selected molecular parameters add value