Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Steve D. Shnyder"'
Autor:
John E. Hart, Sharad Mohan, Keith G. Davies, Ben Ferneyhough, Iain J. Clarke, John A. Hunt, Steve D. Shnyder, Christopher R. Mundy, David R. Howlett, Russell P. Newton
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Background Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degr
Externí odkaz:
https://doaj.org/article/99acd10a6df84f6c8f0199da8142d587
Autor:
Nicholas C. Turner, Alan Ashworth, Margaret A. Knowles, Steve D. Shnyder, James Campbell, Alex Pearson, Maria Teresa Herrera-Abreu
Supplementary Tables 1,2,3 - PDF file 283K, Details of cell lines included in siRNA screen and processed data from screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfc03acb8f9712c7ae5618379498a53
https://doi.org/10.1158/2159-8290.22529765
https://doi.org/10.1158/2159-8290.22529765
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa7a3eeadf697425f73382b1b2ff93
https://doi.org/10.1158/1535-7163.22499368.v1
https://doi.org/10.1158/1535-7163.22499368.v1
Autor:
Nicholas C. Turner, Alan Ashworth, Margaret A. Knowles, Steve D. Shnyder, James Campbell, Alex Pearson, Maria Teresa Herrera-Abreu
Supplementary Figure 1 - PDF file 573K, Analysis of siRNA screen results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3432ab57ba6f2157bc4b8f68337310
https://doi.org/10.1158/2159-8290.22529789.v1
https://doi.org/10.1158/2159-8290.22529789.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by CYP1A1. Elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e7d993df8c3092c76202f58dfbcd09
https://doi.org/10.1158/1535-7163.c.6536128.v1
https://doi.org/10.1158/1535-7163.c.6536128.v1
Autor:
Nicholas C. Turner, Alan Ashworth, Margaret A. Knowles, Steve D. Shnyder, James Campbell, Alex Pearson, Maria Teresa Herrera-Abreu
Supplementary Figure 2 - PDF file 649K, Efficacy of combined targeting of EGFR and FGFR3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f99588d206569848e496f751ab68a9c
https://doi.org/10.1158/2159-8290.22529786
https://doi.org/10.1158/2159-8290.22529786
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 120K, Representative CYP1A1 activity of the EJ138 bladder cell line and EJ138-1A1 bladder cell line, determined by measurement of Ethoxyresorufin O-de-ethylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d566ccd99f7fb819d8b39d53982cf80
https://doi.org/10.1158/1535-7163.22499371.v1
https://doi.org/10.1158/1535-7163.22499371.v1
Autor:
Nicholas C. Turner, Alan Ashworth, Margaret A. Knowles, Steve D. Shnyder, James Campbell, Alex Pearson, Maria Teresa Herrera-Abreu
Supplementary Figure 3 - PDF file 87K, Analysis of cell cycle and apoptosis of FGFR and EGFR combination inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e90e19c49f5c8ecb26c7e8320382f32
https://doi.org/10.1158/2159-8290.22529783.v1
https://doi.org/10.1158/2159-8290.22529783.v1
Autor:
Nicholas C. Turner, Alan Ashworth, Margaret A. Knowles, Steve D. Shnyder, James Campbell, Alex Pearson, Maria Teresa Herrera-Abreu
Supplementary Figure 4 - PDF file 354K, Analysis of the effects on combined EGFR and FGFR3 inhibition, and mechanism of EGFR upregulation by FGFR inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e66a48ea0b1a3feabead088794a95c5
https://doi.org/10.1158/2159-8290.22529780
https://doi.org/10.1158/2159-8290.22529780
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a633e7c506912b1f2b1a15a04c4c2
https://doi.org/10.1158/1535-7163.22499362
https://doi.org/10.1158/1535-7163.22499362