Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Steve D. Paget"'
Autor:
Shao-Gang Li, Alexander L. Perryman, Alex Lemenze, Sean Ekins, Steve D. Paget, Pradeep Kumar, Xin Wang, Thomas P. Stratton, Joel S. Freundlich, Arthur J. Olson
Publikováno v:
ACS Infectious Diseases. 5:2148-2163
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pionee...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6e3505194ba3afaeb6a2674ce9ff0e
https://doi.org/10.1021/acsinfecdis.9b00295
https://doi.org/10.1021/acsinfecdis.9b00295
Autor:
Xin, Wang, Alexander L, Perryman, Shao-Gang, Li, Steve D, Paget, Thomas P, Stratton, Alex, Lemenze, Arthur J, Olson, Sean, Ekins, Pradeep, Kumar, Joel S, Freundlich
Publikováno v:
ACS Infect Dis
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pioneering a computer-aided discovery paradigm that merges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17edbe8f24cd19d28f2b1fff444eb547
https://pubmed.ncbi.nlm.nih.gov/31625383
https://pubmed.ncbi.nlm.nih.gov/31625383
Autor:
Thomas P. Stratton, Patricia Soteropoulos, Joel S. Freundlich, Xin Wang, Hsin Pin Ho, Srinivasan Kandasamy, Seema Hussain, Alejandro Davila-Pagan, Ravindra Jadhav, Daigo Inoyama, Nisha Mittal, Eric Singleton, Sean Ekins, Véronique Dartois, Richard Pottorf, Yong Mo Ahn, Pradeep Kumar, Riccardo Russo, Joseph A. Bilotta, Matthew D. Zimmerman, Courtney Grady, Nancy D. Connell, Thomas J. Kim, Steve D. Paget, Steven Park, Shao-Gang Li
Publikováno v:
Cell Chem Biol
Summary The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef40c52dd7e436750e1c5e66319649f9
https://doi.org/10.1016/j.chembiol.2019.10.010
https://doi.org/10.1016/j.chembiol.2019.10.010
Autor:
Steve D. Paget, Raul Goldschmidt, Barbara D. Foleno, Ellyn Wira, Robert K. Flamm, Karen Bush, Glenda C. Webb, Darren Abbanat, Mark J. Macielag
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:361-365
RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of ≤4 μg/ml, generally exhibiting two- to fourfold-greater pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8cd3c6019a9a6bf7e2ca7142d8bf9b
https://doi.org/10.1128/aac.01017-06
https://doi.org/10.1128/aac.01017-06
Autor:
Anne J. Lenaerts, Marilyn Ekonomidis, Mi Sun Koo, Hiyun Kim, Lisa K. Woolhiser, Steve D. Paget, Barry A. Bunin, Meliza Talaue, Sean Ekins, Robert C. Reynolds, Joel S. Freundlich, Nancy D. Connell
Publikováno v:
Chemistrybiology. 20(3)
Summary Identification of unique leads represents a significant challenge in drug discovery. This hurdle is magnified in neglected diseases such as tuberculosis. We have leveraged public high-throughput screening (HTS) data to experimentally validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff844be34d4714a8be497a0da14b68e8
https://pubmed.ncbi.nlm.nih.gov/23521795
https://pubmed.ncbi.nlm.nih.gov/23521795