Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Steve D. Leach"'
Autor:
Marco Schiavone, Elena Rampazzo, Alessandro Casari, Giusy Battilana, Luca Persano, Enrico Moro, Shu Liu, Steve D. Leach, Natascia Tiso, Francesco Argenton
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 883-894 (2014)
Pancreatic adenocarcinoma, one of the worst malignancies of the exocrine pancreas, is a solid tumor with increasing incidence and mortality in industrialized countries. This condition is usually driven by oncogenic KRAS point mutations and evolves in
Externí odkaz:
https://doaj.org/article/97164d1965eb48629a8ca60691ca70c9
Autor:
Timour Baslan, John P. Morris, Zhen Zhao, Jose Reyes, Yu-Jui Ho, Kaloyan M. Tsanov, Jonathan Bermeo, Sha Tian, Sean Zhang, Gokce Askan, Aslihan Yavas, Nicolas Lecomte, Amanda Erakky, Anna M. Varghese, Amy Zhang, Jude Kendall, Elena Ghiban, Lubomir Chorbadjiev, Jie Wu, Nevenka Dimitrova, Kalyani Chadalavada, Gouri J. Nanjangud, Chaitanya Bandlamudi, Yixiao Gong, Mark T. A. Donoghue, Nicholas D. Socci, Alex Krasnitz, Faiyaz Notta, Steve D. Leach, Christine A. Iacobuzio-Donahue, Scott W. Lowe
Publikováno v:
Nature. 608:795-802
Although p53 inactivation promotes genomic instability1 and presents a route to malignancy for more than half of all human cancers2,3, the patterns through which heterogenous TP53 (encoding human p53) mutant genomes emerge and influence tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d92e4faced4f3453550dbf42fecb004
https://doi.org/10.1038/s41586-022-05082-5
https://doi.org/10.1038/s41586-022-05082-5
Autor:
Jianan Lin, Kamini Singh, Nicolas Lecomte, Hans-Guido Wendel, Prathibha Mohan, Steve D. Leach, Zhengqing Ouyang
Publikováno v:
Cancer Research. 80:1824-1824
G-quadruplex (GQ) elements are conserved translational control elements that induce a requirement for RNA helicase activity for efficient mRNA translation. Computational structure analyses identify multiple GQ elements in the 5'UTRs of mRNAs encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ffb888a2a8baf57fa318112bb147770
https://doi.org/10.1158/1538-7445.am2020-1824
https://doi.org/10.1158/1538-7445.am2020-1824
Autor:
Nicolas Lecomte, Stefan G. Stark, Viraj Sanghvi, Kamini Singh, Askan Gokce, Jianan Lin, Steve D. Leach, Prathibha Mohan, Antonija Burčul, Zhengqing Ouyang, Elisa Destanchia, Rachel Bagni, Gunnar Rätsch, Hans-Guido Wendel, Paul B. Romesser, Agnes Viale, Grbovic-Huezo Olivera, Man Jiang
Publikováno v:
Molecular Cancer Research. 18:B44-B44
New and effective therapeutics are urgently needed for the treatment of pancreatic ductal adenocarcinoma (PDAC). The eIF4A/DDX2 RNA helicase drives translation of mRNAs with highly structured 5′UTRs. The natural compound silvestrol and synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f54639ed90dd13b190d7dd1bc379c84
https://doi.org/10.1158/1557-3125.ras18-b44
https://doi.org/10.1158/1557-3125.ras18-b44
Autor:
A. Scott Pearson, Steve D Leach, David W. Threadgill, R. Daniel Beauchamp, Robert J. Coffey, Robert H. Whitehead
Publikováno v:
Journal of the American College of Surgeons. 191:S86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ca9cc5ff552a51cf39b24c5b0e4866
https://doi.org/10.1016/s1072-7515(00)00642-6
https://doi.org/10.1016/s1072-7515(00)00642-6