Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Steve C Danzer"'
Autor:
Aynara C Wulsin, Ana Franco-Villanueva, Christian Romancheck, Rachel L Morano, Brittany L Smith, Benjamin A Packard, Steve C Danzer, James P Herman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197955 (2018)
Clinical data suggest that the neuroendocrine stress response is chronically dysregulated in a subset of patients with temporal lobe epilepsy (TLE), potentially contributing to both disease progression and the development of psychiatric comorbidities
Externí odkaz:
https://doaj.org/article/7111acca85a54c3d9a3a8245c7ea2b97
Publikováno v:
Frontiers in Neurology, Vol 7 (2016)
Status epilepticus induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and dep
Externí odkaz:
https://doaj.org/article/f7bd67741dcb48dfb2f8d56be7d55940
Autor:
Yifei Jiang, Raymund Y K Pun, Katrina Peariso, Katherine D Holland, Qingquan Lian, Steve C Danzer
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138178 (2015)
There is a clear link between epilepsy and depression. Clinical data demonstrate a 30-35% lifetime prevalence of depression in patients with epilepsy, and patients diagnosed with depression have a three to sevenfold higher risk of developing epilepsy
Externí odkaz:
https://doaj.org/article/955adaa26f9f407089c6ec6c4bbce961
Autor:
Candi L LaSarge, Steve C Danzer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
The PI3K/PTEN-mTOR pathway regulates a variety of neuronal functions, including cell proliferation, survival, growth and plasticity. Dysregulation of the pathway is implicated in the development of both genetic and acquired epilepsies. Indeed, severa
Externí odkaz:
https://doaj.org/article/84867130658f4e0d964c17ada62e1411
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Disruption of inhibitory interneurons is common in the epileptic brain and is hypothesized to play a pivotal role in epileptogenesis. Abrupt disruption and loss of interneurons is well-characterized in status epilepticus models of epilepsy, however,
Externí odkaz:
https://doaj.org/article/224eff835e1048a9a1fa3c42fe47ee04
Autor:
Olagide W Castro, Victor R Santos, Raymund Y K Pun, Jessica M McKlveen, Matthew Batie, Katherine D Holland, Margaret Gardner, Norberto Garcia-Cairasco, James P Herman, Steve C Danzer
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46044 (2012)
Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy. Despite compelling anecdotal evidence for stress-induced seizures, animal models of the phenomena are sparse and possible mechanisms are unclear. Here,
Externí odkaz:
https://doaj.org/article/6c1a5b31cf1b4a76a489710949b0525f
Autor:
Amanda M. McGann, Grace C. Westerkamp, Alisha Chalasani, Cole S. K. Danzer, Emma V. Parkins, Valerine Rajathi, Paul S. Horn, Ernest V. Pedapati, Durgesh Tiwari, Steve C. Danzer, Christina Gross
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundAcquired epilepsies are caused by an initial brain insult that is followed by epileptogenesis and finally the development of spontaneous recurrent seizures. The mechanisms underlying epileptogenesis are not fully understood. MicroRNAs regul
Externí odkaz:
https://doaj.org/article/fe2b1da9a73847029573072fe11c4244
Autor:
Kimberly L. Kraus, Nawshaba Nawreen, Christin M. Godale, Arihant P. Chordia, Ben Packard, Candi L. LaSarge, James P. Herman, Steve C. Danzer
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106014- (2023)
Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense populat
Externí odkaz:
https://doaj.org/article/a19b535276d1474eab8d68fe2e8dbbd5
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105026- (2020)
Epilepsy affects all ages, races, genders, and socioeconomic groups. In about one third of patients, epilepsy is uncontrolled with current medications, leaving a vast need for improved therapies. The causes of epilepsy are diverse and not always know
Externí odkaz:
https://doaj.org/article/bb5722439dfc4391970874582645cad0
Autor:
Victor R. Santos, Raymund Y.K. Pun, Salwa R. Arafa, Candi L. LaSarge, Shane Rowley, Shadi Khademi, Tom Bouley, Katherine D. Holland, Norberto Garcia-Cairasco, Steve C. Danzer
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 339-351 (2017)
Deletion of the mTOR pathway inhibitor PTEN from postnatally-generated hippocampal dentate granule cells causes epilepsy. Here, we conducted field potential, whole cell recording and single cell morphology studies to begin to elucidate the mechanisms
Externí odkaz:
https://doaj.org/article/74ce67b9679e498481eae3c323676666