Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Steve Brocchini"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 631 (2024)
Oxidative stress plays a critical role in the development of chronic ocular conditions including cataracts, age-related macular degeneration, and diabetic retinopathy. There is a need to explore the potential of topical antioxidants to slow the progr
Externí odkaz:
https://doaj.org/article/e7d3b9c182884350a9448b6cc3aa8a37
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Since its discovery, small interfering RNA (siRNA) has revolutionised the field of gene silencing therapy because of its great potential in targeting diseases that were considered untreatable. Although several siRNA drugs are already in the market, m
Externí odkaz:
https://doaj.org/article/4a2ef6be8e504ed88aad9be648229027
Autor:
Sahar Awwad, Nkiruka Ibeanu, Tianyang Liu, Angeliki Velentza-Almpani, Nerisha Chouhan, Stavros Vlatakis, Peng Tee Khaw, Steve Brocchini, Yann Bouremel
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1444 (2023)
Real-time measurement is important in modern dissolution testing to aid in parallel drug characterisation and quality control (QC). The development of a real-time monitoring platform (microfluidic system, a novel eye movement platform with temperatur
Externí odkaz:
https://doaj.org/article/5cda3c065e3241bdb3d5bbe7224b32bc
Autor:
Maria Abedin Zadeh, Raid G. Alany, Leila Satarian, Amin Shavandi, Mohamed Abdullah Almousa, Steve Brocchini, Mouhamad Khoder
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1330 (2023)
There are limited treatments currently available for retinal diseases such as age-related macular degeneration (AMD). Cell-based therapy holds great promise in treating these degenerative diseases. Three-dimensional (3D) polymeric scaffolds have gain
Externí odkaz:
https://doaj.org/article/f8c95bf4dee04546a87156bb517ba76e
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 14-25 (2020)
Glaucoma is the leading cause of irreversible blindness with over 70 million people affected worldwide. The surgical management of glaucoma aims to lower intraocular pressure by increasing aqueous outflow facility. The latest manufacturing techniques
Externí odkaz:
https://doaj.org/article/28811d391d49491fb232578dbd2eae19
Publikováno v:
Nanomaterials, Vol 12, Iss 14, p 2484 (2022)
Therapeutic proteins and peptides are clinically important, offering potency while reducing the potential for off-target effects. Research interest in developing therapeutic polypeptides has grown significantly during the last four decades. However,
Externí odkaz:
https://doaj.org/article/bf5ff524d9c441b4aa8246c0a71acb81
Autor:
Lok Hin Lui, Raphael Egbu, Thomas Graver, Gareth R. Williams, Steve Brocchini, Ajoy Velayudhan
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1462 (2022)
Aggregation resulting from the self-association of peptide molecules remains a major challenge during preformulation. Whereas certain organic solvents are known to promote aggregation, ethanol (EtOH) is capable of disrupting interactions between pept
Externí odkaz:
https://doaj.org/article/67bac31da42049b6979475a517d41ef5
Publikováno v:
Antibodies, Vol 11, Iss 2, p 40 (2022)
Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products. Ag
Externí odkaz:
https://doaj.org/article/0635af4b372f430b85f0c976d41479d7
Autor:
Angeliki Velentza-Almpani, Nkiruka Ibeanu, Tianyang Liu, Christopher Redhead, Peng Tee Khaw, Steve Brocchini, Sahar Awwad, Yann Bouremel
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1267 (2022)
New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion and convection effects on intraocular clearance. Port placement in front ((i) ciliary inflow model) and behind the model lens ((ii) posterior inflow
Externí odkaz:
https://doaj.org/article/5784d17649fd4197b1262c8e4f4b4bcf
Autor:
Xiaoyan Xu, Sahar Awwad, Luis Diaz-Gomez, Carmen Alvarez-Lorenzo, Steve Brocchini, Simon Gaisford, Alvaro Goyanes, Abdul W. Basit
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1421 (2021)
Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of to
Externí odkaz:
https://doaj.org/article/37afcfac38aa4eb780f4a57aad3c42aa