Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Steve Bonello"'
Autor:
Agnes Görlach, Isabel Diebold, Steve Bonello, John R. Hess, Daniela Flügel, Thomas Kietzmann, Sabine Becht, Rachida S. BelAiba
Publikováno v:
Antioxidants & Redox Signaling. 13:425-436
The hypoxia-inducible factor-2alpha (HIF-2alpha) contributes to the vascular response to hypoxia. Hypoxia inhibits prolyl hydroxylation of the N-terminal transactivation domain (N-TAD), thus preventing binding of the von Hippel-Lindau protein (pVHL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98a7e6e92044c47c8b2a236c4005753
https://doi.org/10.1089/ars.2009.3014
https://doi.org/10.1089/ars.2009.3014
Publikováno v:
Thrombosis and Haemostasis. 100:984-991
SummaryVascular remodelling isa complex phenomenon associated with restructuring of the vessel wall as a consequence of disruption of vascular homeostasis. Alterations of the vascular wall have been linked to a variety of cardiovascular disorders inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5829ff17e893e5c370b511577bb71ffb
https://doi.org/10.1160/th08-08-0524
https://doi.org/10.1160/th08-08-0524
Autor:
Agnes Görlach, Steve Bonello, Rachida S. BelAiba, Thomas Kietzmann, Talija Djordjevic, Christian Zähringer, John R. Hess, Carine Michiels
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:755-761
Objective— Reactive oxygen species have been implicated as signaling molecules modulating the activity of redox-sensitive transcription factors such as nuclear factor kappa B (NF-κB). Recently, the transcription factor hypoxia-inducible factor-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9c955428c2ccdd04263d17ad82cfba
https://doi.org/10.1161/01.atv.0000258979.92828.bc
https://doi.org/10.1161/01.atv.0000258979.92828.bc
Autor:
Steve Bonello, Agnes Görlach
Publikováno v:
Biochemical Journal. 412:e17-e19
HIF-1 (hypoxia-inducible factor-1) has been shown to essentially control the cellular response to hypoxia. Hypoxia stabilizes the inducible alpha-subunit, preventing post-translational hydroxylation and subsequent degradation via the proteasome. In r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0372d4808639a1022fd71ad5b0ed8bfa
https://doi.org/10.1042/bj20080920
https://doi.org/10.1042/bj20080920
Publikováno v:
Thrombosis and haemostasis. 100(6)
Vascular remodelling is a complex phenomenon associated with restructuring of the vessel wall as a consequence of disruption of vascular homeostasis. Alterations of the vascular wall have been linked to a variety of cardiovascular disorders including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::490f1ce01e4ae5ba17d277887859cd19
https://pubmed.ncbi.nlm.nih.gov/19132221
https://pubmed.ncbi.nlm.nih.gov/19132221
Autor:
John Hess, Agnes Görlach, Rachida S. BelAiba, Stefanie Schmidt, Christian Zähringer, Thomas Kietzmann, Steve Bonello
Publikováno v:
Molecular biology of the cell. 18(12)
The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of the cellular response to hypoxia. Although the posttranslational regulation of HIF-1alpha by hypoxia is well known, its transcriptional regulation by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4f3f7cd22449f601efdf387dd30a30
https://pubmed.ncbi.nlm.nih.gov/17898080
https://pubmed.ncbi.nlm.nih.gov/17898080
Autor:
Talija Djordjevic, Steve Bonello, Kerstin Diemer, Agnes Görlach, Andreas Petry, Botond Banfi, John Hess, Rachida S. BelAiba, Alexej Pogrebniak, Christian Bickel
Publikováno v:
Free radical biologymedicine. 42(4)
NADPH oxidases have been identified as sources of reactive oxygen species (ROS) in vascular cells. In addition to the initially described enzyme containing gp91phox (NOX2), several homologues to NOX2 have been identified. Whereas NOX1, NOX2, and NOX4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf02ee85d4af12bf05e948123eb9db64
https://pubmed.ncbi.nlm.nih.gov/17275676
https://pubmed.ncbi.nlm.nih.gov/17275676
Autor:
Steve Bonello, Josef Pfeilschifter, Agnes Görlach, John Hess, Talija Djordjevic, Rachida S. BelAiba
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(3)
Background— Human urotensin II (hU-II) is a potent vasoactive peptide possibly involved in pulmonary hypertension. Because the signaling mechanisms activated by this peptide in the pulmonary vasculature are largely unknown, we investigated the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98deef48d837f108f7304c141eaf025
https://pubmed.ncbi.nlm.nih.gov/15618545
https://pubmed.ncbi.nlm.nih.gov/15618545
Autor:
Agnes Görlach, Thomas Kietzmann, Daniela Flügel, Steve Bonello, Rachida S. BelAiba, John Hess, Talija Djordjevic
Publikováno v:
Biological chemistry. 385(3-4)
Pulmonary hypertension and vascular remodeling processes are associated with oxidative stress, hypoxia and enhanced levels of thrombin and vascular endothelial growth factor (VEGF). The hypoxia-inducible transcription factor HIF regulates the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc113eefb942248ab0552be561e4149
https://pubmed.ncbi.nlm.nih.gov/15134338
https://pubmed.ncbi.nlm.nih.gov/15134338
Autor:
Steve Bonello, Christoph Wotzlaw, Helmut Acker, Talija Djordjevic, Agnes Görlach, Rachida S. BelAiba, Alexej Pogrebniak, John Hess
Publikováno v:
Free radical biologymedicine. 38(5)
Endothelial dysfunction is characterized by increased levels of reactive oxygen species (ROS) and a prothrombotic state. The mechanisms linking thrombosis to ROS production in the endothelium are not well understood. We investigated the role of throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f884bb224a628fa24d01fd04efe7659e
https://pubmed.ncbi.nlm.nih.gov/15683718
https://pubmed.ncbi.nlm.nih.gov/15683718