Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Steve Blotner"'
Autor:
SriniVas Sadda, Nancy M. Holekamp, David Sarraf, Adel Ebraheem, Wenying Fan, Lauren Hill, Steve Blotner, Galin Spicer, Shamika Gune
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 260:3781-3789
Purpose To evaluate the relationship between retinal fluid location, amount/severity, and vision with ranibizumab-treated neovascular age-related macular degeneration (nAMD). Methods In the phase 3 HARBOR trial (NCT00891735), treatment-naive patients
Autor:
Barbara A. Blodi, Amitha Domalpally, Ellie Corkery, Aaron Osborne, Steve Blotner, Susanna M. Grzeschik, Shamika Gune
Publikováno v:
Ophthalmology Retina.
Autor:
Wilfried Ernst Erich Eberhardt, Jan H.M. Schellens, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J.L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Vanesa Lopez-Valverde, Avinash Gupta, Max E. Scheulen, Veronique Dieras, Françoise Kraeber-Bodéré, Patricia Tresca, Mark R. Middleton, Suzanne Leijen
PDF file, 1001K, Methods; Supplementary Table 1 - Temporary dose interruptions due to adverse events; Supplementary Table 2 - Changes in biomarker levels between baseline and Day 15; Supplementary Figure 1: Schematic showing dosing cohorts, DLTs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7be86e7d7ff6abbb2f08c3c8e17ccc
https://doi.org/10.1158/1078-0432.22452476.v1
https://doi.org/10.1158/1078-0432.22452476.v1
Autor:
Jean-Charles Soria, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J. L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Ernesto Guarin, Emilie Routier, Federico Rojo, Françoise Kraeber-Bodéré, Saoirse Dolly, Rastilav Bahleda, Joan Albanell, Udai Banerji, Maria Martinez-Garcia
PDF file, 130K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006b8947be1db4b35cb0c1be9eb3d2ac
https://doi.org/10.1158/1078-0432.22451105.v1
https://doi.org/10.1158/1078-0432.22451105.v1
Autor:
Jean-Charles Soria, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J. L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Ernesto Guarin, Emilie Routier, Federico Rojo, Françoise Kraeber-Bodéré, Saoirse Dolly, Rastilav Bahleda, Joan Albanell, Udai Banerji, Maria Martinez-Garcia
Purpose: This phase I study assessed the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety, pharmacokinetics, pharmacodynamics, and clinical activity of the first-in-class dual MEK/RAF inhibitor, RO5126766.Experimental Design: Init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbca345e19eeb5455a74ad1913cfe943
https://doi.org/10.1158/1078-0432.c.6522101
https://doi.org/10.1158/1078-0432.c.6522101
Autor:
Jean-Charles Soria, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J. L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Ernesto Guarin, Emilie Routier, Federico Rojo, Françoise Kraeber-Bodéré, Saoirse Dolly, Rastilav Bahleda, Joan Albanell, Udai Banerji, Maria Martinez-Garcia
PDF file, 18K, Schematic showing cohort doses evaluated, dose-limiting-toxicities observed and maximum-tolerated-doses per dosing regimen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59472046794d1c2b3578f6cc4e14ad1
https://doi.org/10.1158/1078-0432.22451108.v1
https://doi.org/10.1158/1078-0432.22451108.v1
Autor:
Jean-Charles Soria, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J. L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Ernesto Guarin, Emilie Routier, Federico Rojo, Françoise Kraeber-Bodéré, Saoirse Dolly, Rastilav Bahleda, Joan Albanell, Udai Banerji, Maria Martinez-Garcia
PDF file, 9K, Summary of pharmacokinetics of RO4987655 in patients following oral administration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088e1989b219d8b25cb6ff3d615e9d0d
https://doi.org/10.1158/1078-0432.22451102.v1
https://doi.org/10.1158/1078-0432.22451102.v1
Autor:
Wilfried Ernst Erich Eberhardt, Jan H.M. Schellens, Valerie Meresse Naegelen, Steve Blotner, Eliezer Shochat, Jean J.L. Tessier, Ruediger Rueger, Zhi-Xin Xu, Vanesa Lopez-Valverde, Avinash Gupta, Max E. Scheulen, Veronique Dieras, Françoise Kraeber-Bodéré, Patricia Tresca, Mark R. Middleton, Suzanne Leijen
Purpose: This phase I study of the mitogen-activated protein/extracellular signal–regulated kinase inhibitor RO4987655 (CH4987655) assessed its maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety, pharmacokinetic/pharmacodynamic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff974d06dbf6f4cb720dc587268b045
https://doi.org/10.1158/1078-0432.c.6522491
https://doi.org/10.1158/1078-0432.c.6522491
Autor:
Shamika Gune, Nancy M. Holekamp, Lauren Hill, Srinivas R. Sadda, Steve Blotner, Robyn H. Guymer, David Sarraf, Galin Jackson Spicer
Publikováno v:
American journal of ophthalmology. 233
PURPOSE : To investigate the relationship between retinal fluid and vision in ranibizumab-treated patients with neovascular age-related macular degeneration (nAMD). DESIGN Clinical cohort study using post hoc analysis of clinical trial data. METHODS
Autor:
Zhi-Xin Xu, Udai Banerji, Rastilav Bahleda, Jean-Charles Soria, Maria Martinez-Garcia, Joan Albanell, Ernesto Guarin, Ruediger Rueger, Eliezer Shochat, Emilie Routier, Federico Rojo, Valerie Meresse Naegelen, Steve Blotner, Françoise Kraeber-Bodéré, Saoirse Dolly, Jean Tessier
Publikováno v:
Clinical Cancer Research. 18:4806-4819
Purpose: This phase I study assessed the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety, pharmacokinetics, pharmacodynamics, and clinical activity of the first-in-class dual MEK/RAF inhibitor, RO5126766. Experimental Design: Ini