Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Steve Bilodeau"'
Autor:
Christophe Tav, Éric Fournier, Michèle Fournier, Fatemeh Khadangi, Audrey Baguette, Maxime C. Côté, Maruhen A. D. Silveira, Félix-Antoine Bérubé-Simard, Guillaume Bourque, Arnaud Droit, Steve Bilodeau
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Transcription-factor binding to cis-regulatory regions regulates the gene expression program of a cell, but occupancy is often a poor predictor of the gene response. Here, we show that glucocorticoid stimulation led to the reorganization of transcrip
Externí odkaz:
https://doaj.org/article/46a0e08edf1d4f4bbd95e182c99dc81e
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294750 (2023)
Machine learning (ML) algorithms are powerful tools to find complex patterns and biomarker signatures when conventional statistical methods fail to identify them. While the ML field made significant progress, state of the art methodologies to build e
Externí odkaz:
https://doaj.org/article/4fb625a368814489a93ecb37543115b3
Autor:
Romain Villot, Audrey Poirier, Inan Bakan, Karine Boulay, Erlinda Fernández, Romain Devillers, Luciano Gama-Braga, Laura Tribouillard, Andréanne Gagné, Éma Duchesne, Danielle Caron, Jean-Sébastien Bérubé, Jean-Christophe Bérubé, Yan Coulombe, Michèle Orain, Yves Gélinas, Stéphane Gobeil, Yohan Bossé, Jean-Yves Masson, Sabine Elowe, Steve Bilodeau, Venkata Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in
Externí odkaz:
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
Autor:
Clovis Boibessot, Oscar Molina, Gabriel Lachance, Christophe Tav, Audrey Champagne, Bertrand Neveu, Jean‐François Pelletier, Frédéric Pouliot, Vincent Fradet, Steve Bilodeau, Yves Fradet, Alain Bergeron, Paul Toren
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Tumor‐associated macrophages (TAMs) support tumor progression within the tumor microenvironment (TME). Many questions remain as to the origin, development, and function of TAMs within the prostate TME. Evaluation of TAMs in prostate cancer
Externí odkaz:
https://doaj.org/article/37123b3fa5984df0993a810535e42174
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/497bc78248de4d08a2f014f8d187bcc8
Autor:
Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat, Omer H. Yilmaz, Maya Mitalipova, Kevin Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard A. Fine, Anne E. Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard A. Young, Keith L. Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William C. Hahn, Milan G. Chheda
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 313-324 (2014)
Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC mainte
Externí odkaz:
https://doaj.org/article/ec2905833cc54c5e82b2fee25ecd2d48
Autor:
Charles Joly Beauparlant, Fabien C Lamaze, Astrid Deschênes, Rawane Samb, Audrey Lemaçon, Pascal Belleau, Steve Bilodeau, Arnaud Droit
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 8, p e1004751 (2016)
ChIP-Sequencing (ChIP-Seq) provides a vast amount of information regarding the localization of proteins across the genome. The aggregation of ChIP-Seq enrichment signal in a metagene plot is an approach commonly used to summarize data complexity and
Externí odkaz:
https://doaj.org/article/858dc1055f5c4b449ee71839ffe336d3
Autor:
Mick Lee, Loïc Mangnier, Cory C. Padilla, Dominic Paul Lee, Wilson Tan, Peter Yiqing Li, Wen Hao Zheng, Louis Gan, Ching Kit Chen, Yee Phong Lim, Rina Miao Qin Wang, Steve Bilodeau, Alexandre Bureau, Roger Sik-Yin Foo, Chukwuemeka George Anene-Nzelu
The 3D chromatin architecture establishes a complex network of genes and regulatory elements necessary for transcriptomic regulation in development and disease. This network can be modeled by cis-regulatory hubs (CRH) which underscore the local funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc71c356de6843f82b27b0e43caeb93
https://doi.org/10.1101/2022.11.04.515249
https://doi.org/10.1101/2022.11.04.515249
Machine learning (ML) algorithms are powerful tools to find complex patterns and biomarker signatures where conventional statistical methods may fail to identify them. While the ML field made significant progress, state of the art methodologies to bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0139296adec5fe4f83caead78070e01a
https://doi.org/10.1101/2022.10.07.511250
https://doi.org/10.1101/2022.10.07.511250
Autor:
Sabine Elowe, Romain Villot, Yohan Bossé, Stéphane Gobeil, Mathieu Laplante, Inan Bakan, Venkata S. K. Manem, Frédérick A. Mallette, Danielle Caron, Jean-Christophe Bérubé, Steve Bilodeau, Romain Devillers, Yves Gélinas, Yan Coulombe, Laura Tribouillard, Jean-Sébastien Bérubé, Éma Duchesne, Jean-Yves Masson, Michèle Orain, Erlinda Fernández, Luciano Gama-Braga, Audrey Poirier, Karine Boulay, Andréanne Gagné, Philippe Joubert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
RAS proteins are GTPases that lie upstream of a signaling network impacting cell fate determination. How cells integrate RAS activity to balance proliferation and cellular senescence is still incompletely characterized. Here, we identify ZNF768 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d12920290f2df31a87a5119c8e325c9
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068