Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Steve A. Brown"'
Autor:
Hillary Elrick, Kevin A. Peterson, Brandon J. Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. Brown, Adam Caulder, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O. Goodwin, Yann Hérault, Lauri G. Lintott, K. C. Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R. Seavitt, Radislav Sedlacek, William C. Skarnes, Damien Smedley, Sara Wells, Jacqueline K. White, Joshua A. Wood, International Mouse Phenotyping Consortium, Stephen A. Murray, Jason D. Heaney, Lauryl M. J. Nutter
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for i
Externí odkaz:
https://doaj.org/article/0788cc9d0e59472c90243baecc221f96
Autor:
Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114025- (2024)
Summary: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic
Externí odkaz:
https://doaj.org/article/003f391f46fe499b876a09eda87c4a9d
Autor:
Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 355-370 (2022)
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively.
Externí odkaz:
https://doaj.org/article/5942f8bc16104f7a85b0dffab23f1f8b
Autor:
Opeyemi Atanda, Patrick Callaghan, Tim Carter, Graham Durcan, Nick O’Shea, Steve D. Brown, Paula Reavey, Eleni Vangeli, Sarah White, Kerry V. Wood
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Mental Health First Aid (MHFA) is a mental health intervention that teaches people how to identify, understand and help someone who may be experiencing a mental health issue. Reviews of the implementation of MHFA found between 68
Externí odkaz:
https://doaj.org/article/f8b81605e4d847b0848781c6d8e4d998
Autor:
Charles H Knowles, Lesley Booth, Steve R Brown, Samantha Cross, Sandra Eldridge, Christopher Emmett, Ugo Grossi, Mary Jordan, Jon Lacy-Colson, James Mason, John McLaughlin, Rona Moss-Morris, Christine Norton, S Mark Scott, Natasha Stevens, Shiva Taheri, Yan Yiannakou
Publikováno v:
Programme Grants for Applied Research, Vol 9, Iss 14 (2021)
Background: Chronic constipation affects 1–2% of adults and significantly affects quality of life. Beyond the use of laxatives and other basic measures, there is uncertainty about management, including the value of specialist investigations, equipm
Externí odkaz:
https://doaj.org/article/96efbd1e0546422290b69f31ad9a2c81
Autor:
Javier A. Caballero, Steve P. Brown
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Outcomes of processes questioning a physician’s ability to practise —e.g. disciplinary or regulatory— may strongly impact their career and provided care. However, it is unclear what factors relate systematically to such outc
Externí odkaz:
https://doaj.org/article/f0b885603446452784b39554a9fb50f1
Autor:
Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp 1-23 (2019)
Abstract Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive
Externí odkaz:
https://doaj.org/article/aa32f3d7e38046868ba58a51eb9e8d12
Publikováno v:
Colorectal Disease. 25:995-1001
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::641ca8df6cc4fb5a21baada354ff9120
https://doi.org/10.1111/codi.16501
https://doi.org/10.1111/codi.16501
Autor:
Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Debbie Williams, Hayley E. Tyrer, George Nicholson, Steve D.M. Brown, Helen Brown, Chiara Piccinelli, Guillaume Devailly, James Ramsden, Michael T. Cheeseman
Publikováno v:
Frontiers in Genetics, Vol 10 (2020)
Chronic otitis media with effusion (COME) is the most common cause of childhood hearing loss in the developed world. Underlying pathophysiology is not well understood, and in particular the factors that lead to the transition from acute to chronic in
Externí odkaz:
https://doaj.org/article/7b5273a54c93410c993a1cda268e80f9
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The Jeff mouse mutant carries a mutation in the F-box only 11 gene (Fbxo11) and heterozygous animals display conductive deafness due to the development of otitis media (OM). The Fbxo11 locus is also associated with chronic otitis media with effusion
Externí odkaz:
https://doaj.org/article/fbd51b26323b4a8c8438e58f67966add