Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Steve, Peigneur"'
Autor:
Ernesto Lopes Pinheiro-Junior, Ehsan Alirahimi, Steve Peigneur, Jörg Isensee, Susanne Schiffmann, Pelin Erkoc, Robert Fürst, Andreas Vilcinskas, Tobias Sennoner, Ivan Koludarov, Benjamin-Florian Hempel, Jan Tytgat, Tim Hucho, Björn M. von Reumont
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-27 (2024)
Abstract Background The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the
Externí odkaz:
https://doaj.org/article/443dff2f8199411aa434218f16c6ab10
Publikováno v:
Membranes, Vol 14, Iss 5, p 114 (2024)
An insect neuroactive helix ring peptide called U11-MYRTX-Tb1a (abbreviated as U11) from the venom of the ant, Tetramorium bicarinatum. U11 is a 34-amino-acid peptide that is claimed to be one of the most paralytic peptides ever reported from ant ven
Externí odkaz:
https://doaj.org/article/ebeaf8a63998432fbe2421f0fa1b4e29
Autor:
Ahmad Joukhan, Veno Kononenko, Tadeja Bele, Marija Sollner Dolenc, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Jan Tytgat, Tom Turk, Igor Križaj, Damjana Drobne
Publikováno v:
Marine Drugs, Vol 22, Iss 4, p 147 (2024)
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. In this study, we aimed to investigate the potential of APS7-2 and APS8-2, synthetic
Externí odkaz:
https://doaj.org/article/42d0f47ed1724abdaaa70fd7aa45ffa1
Autor:
Ludivine Lopez, Stephan De Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, Steve Peigneur, Barbara Oliveira-Mendes, Sophia Lin, Jolien De Waele, Jérôme Montnach, Sandrine Cestèle, Agnès Tessier, J.P. Johnson, Massimo Mantegazza, Jan Tytgat, Charles Cohen, Rémy Béroud, Frank Bosmans, Céline Landon, Michel De Waard
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115173- (2023)
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies.
Externí odkaz:
https://doaj.org/article/00c037522f374110a6181eefd130b12d
Autor:
Dongchen An, Guilherme Salgado Carrazoni, Ben-Hur Souto das Neves, Rudi D’Hooge, Steve Peigneur, Jan Tytgat
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 454 (2024)
Cannabinoid receptors (CB1 and CB2) are promising targets for a better understanding of neurological diseases. Nevertheless, only a few ligands of CB have reached clinical application so far. Venoms are considered as interesting sources of novel biol
Externí odkaz:
https://doaj.org/article/b5313ba625424979a21860b9a7e63b66
Publikováno v:
Membranes, Vol 13, Iss 12, p 897 (2023)
Histamine receptors (HRs) are G-protein-coupled receptors involved in diverse responses triggered by histamine release during inflammation or by encounters with venomous creatures. Four histamine receptors (H1R–H4R) have been cloned and extensively
Externí odkaz:
https://doaj.org/article/bf3b25f2c31f4ece9450a59cf7e93317
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/f2cfa95bb6d04d45bd3c509fee1db3b1
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 2, Pp 1-21 (2021)
Abstract The development of eukaryote‐derived antimicrobial peptides as systemically administered drugs has proven a challenging task. Here, we report the first human oral actinomyces‐sourced defensin—actinomycesin—that shows promise for syst
Externí odkaz:
https://doaj.org/article/a49a93f8b62d4e539800430463584f0a
Autor:
Alexey I. Kuzmenkov, Steve Peigneur, Joshua A. Nasburg, Konstantin S. Mineev, Maxim V. Nikolaev, Ernesto Lopes Pinheiro-Junior, Alexander S. Arseniev, Heike Wulff, Jan Tytgat, Alexander A. Vassilevski
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial. Here, we investigated the molecular phar
Externí odkaz:
https://doaj.org/article/03250e942dc5484ca71aad07a5e99041
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Over the past decades, envenomation by caterpillars of Automeris spp. became an increasing health problem in Latin America. Accidental contact with the stinging spines of these caterpillars cause acute local pain, itching, inflammation and skin rashe
Externí odkaz:
https://doaj.org/article/eeee2558c89d482fb1be82c7de1c7cdf