Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Steve, McGaraughty"'
Autor:
Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort
Publikováno v:
Bioorganicmedicinal chemistry. 63
The voltage-gated sodium channel Na
Autor:
Arun Kannan, Loren M. Lasko, S.E. Paulsboe, Stephen B. Gauld, Zhi Su, Donna Gauvin, Ryan Duggan, Steve McGaraughty, Victoria E. Scott, Michael E. Kort, P. Honore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Foxp3+ regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce pro-inflammatory cytokines in human diseases, including psoriasis. A significant hurdle in the Treg
Autor:
Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Publikováno v:
Bioorganic & Medicinal Chemistry. 63:116743
Autor:
K. Salte, Yibing Wang, Zhi Su, Steve McGaraughty, Joe Wetter, Laura Leys, Rebecca M. Edelmayer, P. Honore, S.E. Paulsboe, Victoria E. Scott, Stephen B. Gauld, Donna Gauvin, Isaac Weinberg, Marian Namovic
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin,
Autor:
Viktor Todorović, C. Gerstein, Arun Kannan, Li Zhou, S. Huang, S.E. Paulsboe, P. Honore, Ramkrishna Sadhukhan, Victoria E. Scott, Sheeba Mathew, Zhi Su, Leyu Wang, Marian Namovic, Michelle Viner, Rebecca M. Edelmayer, Jane Seagal, Steve McGaraughty, Lisa Rinaldi, Laura Leys, K. Salte, J. Wetter, Amanda Horowitz
Publikováno v:
Experimental Dermatology. 28:113-120
Psoriasis vulgaris (PV) results from activation of IL-23/Th17 immune pathway and is further amplified by cytokines/chemokines from skin cells. Among skin-derived pro-inflammatory cytokines, IL-36 family members are highly upregulated in PV patients a
Autor:
Arthur L. Nikkel, Marian T. Namovic, D. L. Widomski, Diana L. Donnelly-Roberts, Steve McGaraughty, Zhi Su, Laura Leys, Murali Gopalakrishnan
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 29:281-290
Background:Losartan, a blocker of the angiotensin II type I receptor, is an important part of the standard of care for diabetic nephropathy (DN). The obese ZSF-1 rats display many aspects of the clinical features of human Type II DN. The current stud
Autor:
Arthur L. Nikkel, Stella Markosyan, Michael F. Jarvis, Katharine L. Chu, Jill-Desiree Brederson, Robert S. Bitner, Rebecca M. Edelmayer, Steve McGaraughty, Jun Xu
Publikováno v:
Journal of Orthopaedic Research®. 36:2109-2117
Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, howe
Autor:
Anthony M. Giamis, Andrew Goodearl, Christine Grinnell, Kelly J. Doyle, Katherine Salte, Victor Sun, Todd B. Cole, Murali Gopalakrishnan, L. Olson, Susan E. Lacy, Meha Chhaya, Yanping Luo, Steve McGaraughty, Arthur L. Nikkel, Rachel Davis-Taber, Chang Z. Zhu, Gregory M. Preston
Publikováno v:
Journal of the American Society of Nephrology. 28:3616-3626
Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic treatment has had limited success.
Autor:
Jill-Desiree Brederson, Michael J. Dart, Robert G. Schmidt, Steve McGaraughty, Philip R. Kym, Arthur Gomtsyan, Laura Leys, Katharine L. Chu, Richard J. Radek, Jun Xu
Publikováno v:
Journal of Neurophysiology. 118:904-916
TRPV3 is a nonselective cation channel activated by temperatures above 33°C and is reported to be localized in keratinocytes and nervous tissue. To investigate a role for TRPV3 in pain modulation, we conducted a series of in vivo electrophysiologica
Autor:
Arthur L. Nikkel, Ji Ma, L. Olson, Sujatha M. Gopalakrishnan, Kelly J. Doyle, Vivek C. Abraham, D. L. Widomski, Steve McGaraughty, Brent Putman, Murali Gopalakrishnan, Laura Leys, Chang Z. Zhu, Steve D. Pratt, Zhi Su, Chih-Hung Lee, K. Salte
Publikováno v:
European Journal of Pharmacology. 788:1-11
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizi