Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Steve, Jacobsen"'
Autor:
Orest Hurko, Kurt Boudonck, Cathleen Gonzales, Zoe A. Hughes, J. Steve Jacobsen, Peter H. Reinhart, Daniel Crowther
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2010 (2010)
Mice transgenic for production of excessive or mutant forms of beta-amyloid differ from patients with Alzheimer's disease in the degree of inflammation, oxidative damage, and alteration of intermediary metabolism, as well as the paucity or absence of
Externí odkaz:
https://doaj.org/article/f7edad3d5f2b4d2b8217ad8f3679a5eb
Autor:
Steve Jacobsen, Peter H. Reinhart, Albert J. Robichaud, William Ronald Solvibile, Michael S. Malamas, Jim Turner, Koi Michele Morris, Andrea Olland, Ping Zhou, Kristi Fan, Jim Erdei, Menelas N. Pangalos, David Riddell, Dominick Anthony Quagliato, Erik Wagner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6597-6605
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold selectivity for
Autor:
Erik Wagner, Jonathan A. Bard, Kristine Svenson, Guixan Jin, Rajiv Chopra, Mei-Chu Lo, Minakshi Jani, Eric S. Manas, Pawel Nowak, Derek C. Cole, John W. Ellingboe, Baihua Hu, Robichaud Albert Jean, Kristi Fan, Michael S. Malamas, Rani Narasimhan, Jim Turner, Ann Aulabaugh, Ping Zhou, Rebecca Cowling, Steve Jacobsen, Peter H. Reinhart, Joseph Raymond Stock, Joan Subrath
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:632-635
8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (1) was identified through HTS, as a weak (micromolar) inhibitor of BACE1. X-Ray crystallographic studies indicate the 2-aminoimidazole ring forms key H-bonding interactions with Asp32 an
Publikováno v:
Clinical and Translational Science. 2:242-247
With current national emphasis on translational research, data exchange systems are needed that bridge basic science and clinical research. To meet this challenge, an electronic system was developed by the Biomedical Informatics Unit (BMIU) of the Un
Autor:
Erik Wagner, Kevin Atchison, Julius Jefferson, Yolanda Kirksey, J. Steve Jacobsen, Helen K. Warwick, Peter J. Atkinson, Adrienne Parratt, David Riddell, Margaret M. Zaleska, Zhuting Li, Lin Xu, Peter H. Reinhart, Hua Zhou, Menelas N. Pangalos, J. Xu, Suzan Aschmies, Yun Hu
Publikováno v:
The Journal of Neuroscience. 28:11445-11453
Inheritance of the apoE4 allele (epsilon4) increases the risk of developing Alzheimer's disease; however, the mechanisms underlying this association remain elusive. Recent data suggest that inheritance of epsilon4 may lead to reduced apoE protein lev
Autor:
Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe, Rebecca Cowling, Guixian Jin, Eric S. Manas, Kristi Y. Fan, Michael S. Malamas, Boyd L. Harrison, Steve Jacobsen, Rajiv Chopra, Peter A. Lohse, William J. Moore, Mary-Margaret O’Donnell, Yun Hu, Albert J. Robichaud, M. James Turner, Erik Wagner, Jonathan Bard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:767-771
Publikováno v:
Transportation Research Record: Journal of the Transportation Research Board. 1991:78-85
This study determines the effectiveness of the electrochemical chloride extraction (ECE) method on a bridge deck with a high concentration of chloride. ECE was applied on a pedestrian bridge in Iowa to control and mitigate corrosion that occurred in
Autor:
M. James Turner, Lee D. Jennings, Ann Aulabaugh, Derek Cecil Cole, E.S. Manas, Mohani N. Sukhdeo, Steve Jacobsen, Joseph Raymond Stock, Laura Lin, James Strand, Junjun Wu, Mark L. Stahl, John W. Ellingboe, Guixan Jin, and Ping Zhou, Kristi Fan, Boyd L. Harrison, Rajiv Chopra, Kristine Svenson, Frank E. Lovering, Yun Hu, Erik Wagner, Jeffrey Scott Condon, Rebecca Cowling, Michael S. Malamas, Jonathan A. Bard
Publikováno v:
Journal of Medicinal Chemistry. 49:6158-6161
BACE1 is an aspartyl protease responsible for cleaving amyloid precursor protein to liberate Abeta, which aggregates leading to plaque deposits implicated in Alzheimer's disease. We have identified small-molecule acylguanidine inhibitors of BACE1. Cr
Publikováno v:
Biochemical Society Transactions. 33:553-558
AD (Alzheimer's disease) is characterized neuropathologically by the presence of amyloid plaques, neurofibrillary tangles and profound grey matter loss. The ‘amyloid’ hypothesis postulates that the toxic Aβ (amyloid β) peptide, enzymatically de
Autor:
Brad Poland, Peter H. Reinhart, Christopher Conrad, Megan Foley, Brad Tait, Eva Nokes, Peter Lee-Armandt, David Hurtado, James Soper, Randy King, Andres Hurtado-Lorenzo, Bob Chambers, Brad Geddes, Steve Jacobsen, Mohmmad Hafiz, Jyoti Malhotra, Byung-Hoon Lee, Eric Roskelley, Dee Shen, Akhil Bhalla, Dan Finley, Dan Garza, Jennifer Andersen
Publikováno v:
Alzheimer's & Dementia. 8