Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Steve, Hoffmann"'
Autor:
Katjana Schwab, Konstantin Riege, Luis Coronel, Clara Stanko, Silke Förste, Steve Hoffmann, Martin Fischer
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract The transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor s
Externí odkaz:
https://doaj.org/article/e534e98200654b9791d782f12a46e429
Autor:
Maja Olecka, Alena van Bömmel, Lena Best, Madlen Haase, Silke Foerste, Konstantin Riege, Thomas Dost, Stefano Flor, Otto W. Witte, Sören Franzenburg, Marco Groth, Björn von Eyss, Christoph Kaleta, Christiane Frahm, Steve Hoffmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although DNA methylation data yields highly accurate age predictors, little is known about the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the gap, we investigate the methylation trajectories of male mouse
Externí odkaz:
https://doaj.org/article/1b1921c741ae4512a8ba29546dcdf82a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Arguably, the most important tool for many computational scientists is the Linux shell. Processing steps carried out there are critical for a large number of analyses. While the manual documentation of the work is time-consuming and error-pr
Externí odkaz:
https://doaj.org/article/e19d9cd0d27442e6b1bd452fb83cef2a
Autor:
Aimer Gutierrez-Diaz, Steve Hoffmann, Juan Carlos Gallego-Gómez, Clara Isabel Bermudez-Santana
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
In recent years, a population of small RNA fragments derived from non-coding RNAs (sfd-RNAs) has gained significant interest due to its functional and structural resemblance to miRNAs, adding another level of complexity to our comprehension of small-
Externí odkaz:
https://doaj.org/article/f40d94699c2f4481b8fc963d451d7ea0
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1263-1279 (2023)
The role of long non‐coding RNAs (lncRNAs) in p53‐mediated tumor suppression has become increasingly appreciated in the past decade. Thus, the identification of p53‐regulated lncRNAs can be a promising starting point to select and prioritize ln
Externí odkaz:
https://doaj.org/article/fb9270f6f1484f3687932eef570a71d3
Autor:
Katjana Schwab, Luis Coronel, Konstantin Riege, Erika K. Sacramento, Norman Rahnis, David Häckes, Emilio Cirri, Marco Groth, Steve Hoffmann, Martin Fischer
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 res
Externí odkaz:
https://doaj.org/article/49b81b484eb94360a680e1b62c99d075
Autor:
Kshitij Mohan, Gilles Gasparoni, Abdulrahman Salhab, Michael M. Orlich, Robert Geffers, Steve Hoffmann, Ralf H. Adams, Jörn Walter, Alfred Nordheim
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 17 (2023)
Background Stroke is a leading global cause of human death and disability, with advanced aging associated with elevated incidences of stroke. Despite high mortality and morbidity of stroke, the mechanisms leading to blood‐brain barrier dysfunction
Externí odkaz:
https://doaj.org/article/5b838257a8fd44fc983becdab8d16c8c
Autor:
Kyung Mok Kim, Anna Mura-Meszaros, Marie Tollot, Murali Shyam Krishnan, Marco Gründl, Laura Neubert, Marco Groth, Alejo Rodriguez-Fraticelli, Arthur Flohr Svendsen, Stefano Campaner, Nico Andreas, Thomas Kamradt, Steve Hoffmann, Fernando D. Camargo, Florian H. Heidel, Leonid V. Bystrykh, Gerald de Haan, Björn von Eyss
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immune system function declines with age, a consequence of defects in hematopoietic stem cells (HSCs). Here the authors show that TAZ buffers age-related loss of PU.1 activity to maintain HSC functionality and identify the surface protein Clca3a1 as
Externí odkaz:
https://doaj.org/article/0df33a5033d34a94b2095134ddb5b5a1
Autor:
Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated who
Externí odkaz:
https://doaj.org/article/3d3b5d4cbb534e4eb3816d334f4e9a3c
Autor:
Susanne Holtze, Ekaterina Gorshkova, Stan Braude, Alessandro Cellerino, Philip Dammann, Thomas B. Hildebrandt, Andreas Hoeflich, Steve Hoffmann, Philipp Koch, Eva Terzibasi Tozzini, Maxim Skulachev, Vladimir P. Skulachev, Arne Sahm
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caeno
Externí odkaz:
https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3