Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Steve, Bourgault"'
Autor:
Cynthia Calzas, Tamiru N. Alkie, Matthew Suderman, Carissa Embury-Hyatt, Vinay Khatri, Ronan Le Goffic, Yohannes Berhane, Steve Bourgault, Denis Archambault, Christophe Chevalier
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Current poultry vaccines against influenza A viruses target the globular head region of the hemagglutinin (HA1), providing limited protection against antigenically divergent strains. Experimental subunit vaccines based on the conserved ectod
Externí odkaz:
https://doaj.org/article/204c6c5af4c74caf9732f1dfd3dcefd7
Autor:
Nadjib Kihal, Phuong Trang Nguyen, Ali Nazemi, Andrea A. Greschner, Marc A. Gauthier, Steve Bourgault
Publikováno v:
Aggregate, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract The deposition of insoluble proteinaceous aggregates in the form of amyloid fibrils within the extracellular space of tissues is associated with numerous diseases. The development of molecular approaches to arrest amyloid formation and preve
Externí odkaz:
https://doaj.org/article/8a7b073bebaf465984d2797aa76b2b6e
Autor:
Marie-Jeanne Archambault, Laetitia Mwadi Tshibwabwa, Mélanie Côté-Cyr, Serge Moffet, Tze Chieh Shiao, Steve Bourgault
Publikováno v:
Vaccines, Vol 12, Iss 11, p 1290 (2024)
Glycoconjugate vaccines have been effective in preventing numerous bacterial infectious diseases and have shown recent potential to treat cancers through active immunotherapy. Soluble polysaccharides elicit short-lasting immune responses and are usua
Externí odkaz:
https://doaj.org/article/617528a155a94ac2a56574957faf5afa
Autor:
Nicolas Chofflet, Yusuke Naito, Anthony John Pastore, Nirmala Padmanabhan, Phuong Trang Nguyen, Christian Poitras, Benjamin Feller, Nayoung Yi, Jeremie Van Prooijen, Husam Khaled, Benoit Coulombe, Steven J. Clapcote, Steve Bourgault, Tabrez J. Siddiqui, Gabby Rudenko, Hideto Takahashi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The prevailing model behind synapse development and specificity is that a multitude of adhesion molecules engage in transsynaptic interactions to induce pre- and postsynaptic assembly. How these extracellular interactions translate into intracellular
Externí odkaz:
https://doaj.org/article/b0e5ea6d61414d33a1c87b6f1bb93555
Publikováno v:
Bio-Protocol, Vol 13, Iss 19 (2023)
Disruptions and perturbations of the cellular plasma membrane by peptides have garnered significant interest in the elucidation of biological phenomena. Typically, these complex processes are studied using liposomes as model membranes—either by enc
Externí odkaz:
https://doaj.org/article/e7184de4b7e440919151dce04c86b46e
Autor:
Mathilde Fortier, Mélanie Côté-Cyr, Vy Nguyen, Margaryta Babych, Phuong Trang Nguyen, Roger Gaudreault, Steve Bourgault
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes. Therapeutic interventions targeting IAPP amyloidogenesis, wh
Externí odkaz:
https://doaj.org/article/ffea88f71a8c4e1e8dd62149cfd92b4f
Autor:
Phuong Trang Nguyen, Ximena Zottig, Mathew Sebastiao, Alexandre A. Arnold, Isabelle Marcotte, Steve Bourgault
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these st
Externí odkaz:
https://doaj.org/article/28feaf14cc72438f8c537516bcfa2027
Autor:
Elisabeth M M A Andriessen, François Binet, Frédérik Fournier, Masayuki Hata, Agnieszka Dejda, Gaëlle Mawambo, Sergio Crespo‐Garcia, Frédérique Pilon, Manuel Buscarlet, Karine Beauchemin, Véronique Bougie, Garth Cumberlidge, Ariel M Wilson, Steve Bourgault, Flavio A Rezende, Normand Beaulieu, Jean‐Sébastien Delisle, Przemyslaw Sapieha
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-14 (2021)
Abstract Age‐related macular degeneration (AMD) in its various forms is a leading cause of blindness in industrialized countries. Here, we provide evidence that ligands for neuropilin‐1 (NRP1), such as Semaphorin 3A and VEGF‐A, are elevated in
Externí odkaz:
https://doaj.org/article/4736161cc8494b3eae5cc70e5a854d66
Autor:
Benjamin Feller, Aurélie Fallon, Wen Luo, Phuong Trang Nguyen, Irina Shlaifer, Alfred Kihoon Lee, Nicolas Chofflet, Nayoung Yi, Husam Khaled, Samer Karkout, Steve Bourgault, Thomas M. Durcan, Hideto Takahashi
Publikováno v:
Cells, Vol 12, Iss 7, p 1083 (2023)
Synucleinopathies form a group of neurodegenerative diseases defined by the misfolding and aggregation of α-synuclein (α-syn). Abnormal accumulation and spreading of α-syn aggregates lead to synapse dysfunction and neuronal cell death. Yet, little
Externí odkaz:
https://doaj.org/article/ec846f0a1d9c4c59a6b9e39268220685
Autor:
Cynthia Calzas, Molida Mao, Mathilde Turpaud, Quentin Viboud, Joelle Mettier, Thomas Figueroa, Pierre Bessière, Antoine Mangin, Laura Sedano, Pierre-Louis Hervé, Romain Volmer, Mariette F. Ducatez, Steve Bourgault, Denis Archambault, Ronan Le Goffic, Christophe Chevalier
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Current inactivated vaccines against influenza A viruses (IAV) mainly induce immune responses against highly variable epitopes across strains and are mostly delivered parenterally, limiting the development of an effective mucosal immunity. In this st
Externí odkaz:
https://doaj.org/article/ce5eeb8fd4fc4f3c89ecec190951fa7b