Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Steve, Arns"'
Autor:
Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge, Haakon B. Nygaard
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the progranulin gene (GRN
Externí odkaz:
https://doaj.org/article/a734b9c2da774facb813e45baefeeee9
Autor:
Yue Shen, Matthew R. Zeglinski, Christopher T. Turner, Sheetal A. Raithatha, Zhenguo Wu, Valerio Russo, Cameron Oram, Sho Hiroyasu, Layla Nabai, Hongyan Zhao, Tatjana Bozin, Kathryn Westendorf, Irina Kopko, Rachel Huang, Steve Arns, Jason Tan, Haishan Zeng, Anthony Boey, Richard Liggins, James Jaquith, Dale R. Cameron, Anthony Papp, David J. Granville
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Chronic wounds: Gel encourages healing and reduces scarring A promising, recently developed topical treatment prevents detrimental enzyme activity in burn wounds, accelerates healing and reduces scarring. Chronic wounds that do not heal fully and req
Externí odkaz:
https://doaj.org/article/14e3cf5a39f347f1ae1f7819d91fe470
Autor:
Howard Feldman, Tyler Yan, Xiujuan Wu, Aruna D. Balgi, Karen Jansen-West, Ian R. A. Mackenzie, Fen-Biao Gao, Fahimeh S. Shidmoossavee, Steve Arns, Jason Samuel Tan, Alireza Baradaran-Heravi, Michel Roberge, Haakon B. Nygaard, Francis C. Lynn, Leonard Petrucelli, James Brian Jaquith, Jonathan Frew
Publikováno v:
Molecular Neurodegeneration
Molecular neurodegeneration, vol 15, iss 1
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Molecular neurodegeneration, vol 15, iss 1
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Background Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the progranulin gene (GRN) is an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7654cb6c8656a70901ac245e8f2873e
http://europepmc.org/articles/PMC7075020
http://europepmc.org/articles/PMC7075020
Autor:
Yoko Shimizu, S.-H. Sheldon Tai, Nag S. Kumar, Michel Roberge, Elyse Bourque, Masahiro Niikura, Olga Agafitei, James Brian Jaquith, Fahimeh S. Shidmoossavee, Steve Arns, Aruna D. Balgi, Tom A. Pfeifer, Sharon Sun
Publikováno v:
European Journal of Medicinal Chemistry. 120:64-73
The development of treatments for influenza that inhibit the M2 proton channel without being susceptible to the widespread resistance mechanisms associated with the adamantanes is an ongoing challenge. Using a yeast high-throughput yeast growth resto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4259f7f901456b1337e25c33bf39323a
https://doi.org/10.1016/j.ejmech.2016.05.008
https://doi.org/10.1016/j.ejmech.2016.05.008
Autor:
Robert N. Young, Gang Chen, Careesa C Liu, Steve Arns, Sally Hu, John Georgiou, Nag S. Kumar, Marc D. Grynpas
Publikováno v:
Journal of Bone and Mineral Research. 30:670-680
Current treatments for postmenopausal osteoporosis aim to either promote bone formation or inhibit bone resorption. The C1 conjugate drug represents a new treatment approach by chemically linking the antiresorptive compound alendronate (ALN) with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43739194426f02a34054b7aa0c10aff
https://doi.org/10.1002/jbmr.2382
https://doi.org/10.1002/jbmr.2382
Autor:
Tatjana Bozin, Christopher T. Turner, Sho Hiroyasu, James Brian Jaquith, Haishan Zeng, Matthew R. Zeglinski, Valerio Russo, Kathryn Westendorf, David J. Granville, Steve Arns, Richard Liggins, Cameron Oram, Yue Shen, Layla Nabai, Dale R. Cameron, Sheetal A. Raithatha, Irina Kopko, Rachel Huang, Jason Samuel Tan, Zhenguo Wu, Anthony Papp, Anthony Boey, Hongyan Zhao
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Granzyme B (GzmB) is a serine protease that has long been thought to function exclusively in lymphocyte-mediated apoptosis. In recent years, this paradigm has been revisited due to the recognition that GzmB accumulates in the extracellular milieu in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91e73d21459bd074383214d31f8f65f
https://pubmed.ncbi.nlm.nih.gov/29849046
https://pubmed.ncbi.nlm.nih.gov/29849046
Publikováno v:
Chemistry - A European Journal. 16:14124-14130
We report herein a detailed investigation into the reaction mechanism for a sequential oxy-Cope/ene reaction under anionic conditions. With DFT calculations and ab initio molecular dynamics simulations, the observed diastereoselectivity is shown to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4255cbcc27a238a990022152c16ac39d
https://doi.org/10.1002/chem.201001302
https://doi.org/10.1002/chem.201001302
Publikováno v:
The Journal of Organic Chemistry. 72:9314-9322
In this article, we report a highly diastereoselective new method for the generation of quaternary carbon centers through an anionic oxy-Cope/alkylation sequence where the diastereoselectivity is induced by the conformation of a macrocyclic tetrasubs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910b6c45c4a3cdae418fbe512211fa21
https://doi.org/10.1021/jo701833v
https://doi.org/10.1021/jo701833v
Autor:
Adam Galey, Stephen G. Withers, Natalia Zisman, Jenna Udechukwu, Jay Paquette, Jason Samuel Tan, Elyse Bourque, Samantha Dercho, Richard Liggins, Fiona C. Ross, Sharon Sun, Murray S. Webb, Vionarica Gusti, Steve Arns
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(12)
Difluorosialic acids (DFSAs) are potent inhibitors of viral neuraminidase that demonstrate activity against oseltamivir- and zanamivir-resistant strains of influenza. Unfortunately, low oral bioavailability precludes their development as second gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaaa368eb4ca20532f048e2ebb710d2
https://pubmed.ncbi.nlm.nih.gov/25980910
https://pubmed.ncbi.nlm.nih.gov/25980910
Autor:
Graham J. Bodwell, Bradley L. Merner, Lawrence T. Scott, Patrick M. Merner, Steve Arns, Vikki M. Tsefrikas, C. Chad Warford
Publikováno v:
Organic Letters. 8:5195-5198
[Structure: see text] Flash vacuum pyrolysis of 7,10-bis(2-bromophenyl)acenaphtho[1,2-d]pyridazine (C26H14Br2N2) has resulted in a surprising transformation, including dinitrogen loss, to give benzo[a]acecorannulene, a novel C26H12 bowl-shaped fuller
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f4acc26d2ac10e5dd91a566361c372
https://doi.org/10.1021/ol061554v
https://doi.org/10.1021/ol061554v