Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies

Autor: Simon Gonzalez, Dirk Tourwé, Philippe Sarret, Mariana Spetea, Florine Cavelier, Santo Previti, Charlotte Martin, Linda Kunze, Mélanie Vivancos, Stevany Louis, Louis Gendron, Elke Dewolf, Maria Dumitrascuta, Steven Ballet, Emilie Eiselt, Annalisa Blasiol

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (21), pp.12929-12941. ⟨10.1021/acs.jmedchem.0c01376⟩

International audience; Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-D-Arg-Aba-β-Ala-NH 2 (KGOP01) was fused t

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https://biblio.vub.ac.be/vubir/optimized-opioidneurotensin-multitarget-peptides-from-design-to-structureactivity-relationship-studies(b5565787-3be0-4e48-8dac-9092ed30584e).html