Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Stergios J Moschos"'
Autor:
Irene Orlow, Keimya D Sadeghi, Sharon N Edmiston, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick, InterMEL Consortium
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0269324 (2023)
IntroductionWe are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of gener
Externí odkaz:
https://doaj.org/article/2122630446b94345873b74cdda1850a8
Autor:
Xiaobei Zhao, Anyou Wang, Vonn Walter, Nirali M Patel, David A Eberhard, Michele C Hayward, Ashley H Salazar, Heejoon Jo, Matthew G Soloway, Matthew D Wilkerson, Joel S Parker, Xiaoying Yin, Guosheng Zhang, Marni B Siegel, Gary B Rosson, H Shelton Earp, Norman E Sharpless, Margaret L Gulley, Karen E Weck, D Neil Hayes, Stergios J Moschos
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129280 (2015)
The recent FDA approval of the MiSeqDx platform provides a unique opportunity to develop targeted next generation sequencing (NGS) panels for human disease, including cancer. We have developed a scalable, targeted panel-based assay termed UNCseq, whi
Externí odkaz:
https://doaj.org/article/2c37c10a3dab4f3a8c63f529bbfad74a
Autor:
Michelle Barbi de Moura, Garret Vincent, Shelley L Fayewicz, Nicholas W Bateman, Brian L Hood, Mai Sun, Joseph Suhan, Stefan Duensing, Yan Yin, Cindy Sander, John M Kirkwood, Dorothea Becker, Thomas P Conrads, Bennett Van Houten, Stergios J Moschos
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40690 (2012)
The importance of mitochondria as oxygen sensors as well as producers of ATP and reactive oxygen species (ROS) has recently become a focal point of cancer research. However, in the case of melanoma, little information is available to what extent cell
Externí odkaz:
https://doaj.org/article/72cadaeade94434ba5ad00dba5a37a23
Autor:
Georgia Sofia Karachaliou, Rached Alkallas, Sarah B. Carroll, Chongshan Caressi, Danny Zakria, Nirali M. Patel, Dimitri G. Trembath, Jennifer A. Ezzell, Guillaume J. Pegna, Paul B. Googe, Jonathan P. Galeotti, Fatih Ayvali, Frances A. Collichio, Carrie B. Lee, David W. Ollila, Margaret L. Gulley, Douglas B. Johnson, Kevin B. Kim, Ian R. Watson, Stergios J. Moschos
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance
Externí odkaz:
https://doaj.org/article/e37d57623fe24adeb9a71ff470be1281
Autor:
Daniel A. Rodriguez, Jessica Yang, Michael A. Durante, Alexander N. Shoushtari, Stergios J. Moschos, Kazimierz O. Wrzeszczynski, J. William Harbour, Richard D. Carvajal
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and leads to deadly metastases for which there is no approved treatment. Genetic events driving early tumor development are well-described, but those occurring l
Externí odkaz:
https://doaj.org/article/a14dce398f0e41c38acdb3290d8128a5
Autor:
Sara R. Selitsky, Lisle E. Mose, Christof C. Smith, Shengjie Chai, Katherine A. Hoadley, Dirk P. Dittmer, Stergios J. Moschos, Joel S. Parker, Benjamin G. Vincent
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in s
Externí odkaz:
https://doaj.org/article/b294449e664343b7b7d49abaff4d5f78
Autor:
Xuedan Wu, Xinrui Ma, Yaofeng Zhong, Wei Chen, Muyun Xu, He Zhang, Li Wang, Xianshuang Tu, Zhaoguo Han, Weiling Zhao, Zhanhong Wu, Stergios J. Moschos, Zibo Li
Publikováno v:
Journal of Medicinal Chemistry. 66:3262-3272
Autor:
Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Kara Z. Lo, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, Roger S. Lo
Publikováno v:
Cancer discovery, vol 13, iss 4
Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastati
Autor:
Dimitri G. Trembath, Eric S. Davis, Shanti Rao, Evan Bradler, Angelica F. Saada, Bentley R. Midkiff, Anna C. Snavely, Matthew G. Ewend, Frances A. Collichio, Carrie B. Lee, Georgia-Sofia Karachaliou, Fatih Ayvali, David W. Ollila, Michal T. Krauze, John M. Kirkwood, Benjamin G. Vincent, Nana Nikolaishvilli-Feinberg, Stergios J. Moschos
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
BackgroundHigh tumor-infiltrating lymphocytes (TILs) and hemorrhage are important prognostic factors in patients who have undergone craniotomy for melanoma brain metastases (MBM) before 2011 at the University of Pittsburgh Medical Center (UPMC). We h
Externí odkaz:
https://doaj.org/article/ba7880ac0a654f77a17bdb4209fa40aa
Autor:
Sixue Liu, Prashanthi Dharanipragada, Shirley H. Lomeli, Yan Wang, Xiao Zhang, Zhentao Yang, Raymond J. Lim, Camelia Dumitras, Philip O. Scumpia, Steve M. Dubinett, Gatien Moriceau, Douglas B. Johnson, Stergios J. Moschos, Roger S. Lo
Publikováno v:
Nature medicine, vol 29, iss 5
Metastasis and failure of present-day therapies represent the most common causes of mortality in patients with cutaneous melanoma. To identify the underlying genetic and transcriptomic landscapes, in this study we analyzed multi-organ metastases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5318bf99218234a1a5a9d8f3309df644
https://escholarship.org/uc/item/62m629hn
https://escholarship.org/uc/item/62m629hn