Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Stergios, Tsartsalis"'
Autor:
Benjamin B. Tournier, Kelly Ceyzériat, Aurélien M. Badina, Yesica Gloria, Aïda B. Fall, Quentin Amossé, Stergios Tsartsalis, Philippe Millet
Publikováno v:
NeuroImage, Vol 298, Iss , Pp 120778- (2024)
Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early
Externí odkaz:
https://doaj.org/article/8b69a57b42f94d7989c9983cda13c925
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen, Paul M. Matthews
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulating body of research indicates t
Externí odkaz:
https://doaj.org/article/81c1c0ceb9654d9fb3fc373fa3501b08
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Alzheimer’s disease (AD) is characterized by amyloid (Aβ) protein aggregation and neurofibrillary tangles accumulation, accompanied by neuroinflammation. With all the therapeutic attempts targeting these biomarkers having been unsuccessfu
Externí odkaz:
https://doaj.org/article/1fd7e2b173d64bf296cc67fcccdb9cd1
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Several studies suggested that 5-HT2A receptor (5-HT2AR) blockade may provide a more favorable efficacy and side-effect profile to antipsychotic treatment. We hypothesized that a combined haloperidol (a D2/3 receptor (D2/3R) antagonist) and
Externí odkaz:
https://doaj.org/article/73df8a9717c24e598b8d61cf06556584
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background [123I]epidepride is a high-affinity radiotracer used in single-photon emission computed tomography (SPECT) imaging of the D2/3 receptors. It binds with high affinity to striatal and extrastriatal receptors. Nevertheless, its slow
Externí odkaz:
https://doaj.org/article/923d957bc97545a4917fcd9268456f78
Autor:
Benjamin B. Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Millet
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100045- (2022)
Increase in the brain expression of the 18 kDa translocator protein (TSPO) is considered as a marker of neuroinflammation in the context of brain diseases, such as Alzheimer’s disease (AD). However, in non-demented subjects with Alzheimer’s neuro
Externí odkaz:
https://doaj.org/article/259c99b3fafb4c8393cf7247864fc934
Autor:
Benjamin B. Tournier, Stergios Tsartsalis, Daphney Rigaud, Christine Fossey, Thomas Cailly, Frédéric Fabis, Tien Pham, Marie-Claude Grégoire, Eniko Kövari, Marcelle Moulin-Sallanon, Armand Savioz, Philippe Millet
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 95-105 (2019)
The involvement of the 18kDa translocator protein (TSPO), a marker of neuroinflammation, in Alzheimer's disease (AD) remains controversial. In the present report, we used [125I]-CLINDE, a SPECT TSPO radiotracer never before used in AD, and we investi
Externí odkaz:
https://doaj.org/article/e4b1ea0f57544133879fc9ea7928babf
Autor:
Benjamin B. Tournier, Stergios Tsartsalis, Kelly Ceyzériat, Valentina Garibotto, Philippe Millet
Publikováno v:
Cells, Vol 9, Iss 9, p 1941 (2020)
In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TS
Externí odkaz:
https://doaj.org/article/db0dd2149e664e71b0c62ea469be7ec1