New insights into the hypothalamic-pituitary-thyroid axis: a transcriptome- and proteome-wide association study.

Autor: Monteiro-Martins S; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Sterenborg RBTM; Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Borisov O; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Scherer N; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany., Cheng Y; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Medici M; Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Teumer A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Publikováno v: European thyroid journal [Eur Thyroid J] 2024 Jun 20; Vol. 13 (3). Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.

Autor: Sterenborg RBTM; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Steinbrenner I; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Li Y; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Bujnis MN; The University of Utah, Salt Lake City, UT, USA., Naito T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Digital Environment Research Institute, Queen Mary University of London, London, UK., Galesloot TE; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands., Babajide O; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Andreasen L; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Astrup A; Department of Obesity and Nutritional Sciences, The Novo Nordisk Foundation, Hellerup, Denmark., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Bandinelli S; Geriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy., Beekman M; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Beilby JP; School of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Boutin T; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brown SJ; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia., Brumpton B; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway., Campbell PJ; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia., Cappola AR; Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, PA, USA., Ceresini G; Oncological Endocrinology, University of Parma, Parma, Italy.; Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., Chaker L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Coutinho de Almeida R; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Cross SM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.; Università di Sassari, Dipartimento di Scienze Biomediche, V.le San Pietro, 07100, Sassari (SS), Italy., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Kjaergaard AD; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Blvd. 11, Entrance A, 8200, Aarhus, Denmark., Echouffo Tcheugui JB; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Ellervik C; Harvard Medical School, Boston, USA.; Faculty of Medical Science, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark., Eriksson JG; Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland.; National University Singapore, Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology, Singapore, Singapore., Ferrucci L; Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Freudenberg J; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Fuchsberger C; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA., Gögele M; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Graham SE; Department of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gunjača I; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harding BN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Barcelona Institute for Global Health, Barcelona, Spain., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Haunsø S; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom., Hui J; Pathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.; School of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia., Ittermann T; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kajantie E; Finnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Oulu, Finland.; Clinical Medicine Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Kanters JK; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center of Physiological Research, University of California San Francisco, San Francisco, USA., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Kiemeney LALM; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands., Kloppenburg M; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Kühnel B; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Lapauw B; Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium., Leese G; NHS Tayside, Scotland, Dundee, UK., Li S; Department of Biostatistics, Boston University, Boston, MA, USA., Liewald DCM; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Linneberg A; Center of Physiological Research, University of California San Francisco, San Francisco, USA.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lominchar JVT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Matana A; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia., Meima ME; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Meitinger T; Institute for Human Genetics, Technical University of Munich, Munich, Germany., Meulenbelt I; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Mitchell BD; University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, 21201, USA., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Mora S; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Naitza S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Nauck M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Netea-Maier RT; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Nursyifa C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan., Onano S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Papadopoulou A; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Palmer CNA; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Pattaro C; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev-Gentofte University Hospital, Copenhagen, Denmark., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany., Pietzner M; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Polašek O; Department of Public Health, University of Split, School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Pramstaller PP; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Punda A; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Redmond P; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Richards JB; Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Russ TC; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom., Ryan KA; University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA., Olesen MS; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Schultheiss UT; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Siddiqui MK; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Slagboom PE; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Soto-Pedre E; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Spector TD; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK., Spedicati B; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Srinivasan S; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Starr JM; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tanaka T; Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Torlak V; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Tuhkanen J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., van den Akker EB; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands., van den Eynde T; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., van der Klauw MM; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Verroken C; Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium., Visser WE; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Vojinovic D; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Walsh JP; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.; Medical School, The University of Western Australia, Crawley, WA, 6009, Australia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Weiss S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Willer CJ; Department of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Wilson SG; School of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia.; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wouters HJCM; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wright MJ; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia., Yang Q; Department of Biostatistics, Boston University, Boston, MA, USA., Zemunik T; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia.; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Zhou W; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA., Smit JWA; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Peeters RP; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany. ateumer@uni-greifswald.de.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. ateumer@uni-greifswald.de., Medici M; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands. m.medici@erasmusmc.nl.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. m.medici@erasmusmc.nl.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 30; Vol. 15 (1), pp. 888. Date of Electronic Publication: 2024 Jan 30.

The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations.

Autor: Sterenborg RBTM; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland., Netea-Maier RT; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Speed D; Department of Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark., Meima ME; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Visser WE; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Smit JWA; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Peeters RP; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Medici M; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 May 17; Vol. 107 (6), pp. e2276-e2283.

Thyroid Function and Mood Disorders: A Mendelian Randomization Study.

Autor: Kuś A; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland., Kjaergaard AD; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, United Kingdom., Del Greco M F; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy., Sterenborg RBTM; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Chaker L; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Peeters RP; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Bednarczuk T; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Burgess S; MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, United Kingdom.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Ellervik C; Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Medici M; Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Thyroid : official journal of the American Thyroid Association [Thyroid] 2021 Aug; Vol. 31 (8), pp. 1171-1181. Date of Electronic Publication: 2021 May 26.