Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.

Autor: Stephenson ZA; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Harvey RF; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Pryde KR; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Mistry S; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Hardy RE; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Serreli R; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom., Chung I; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom., Allen TE; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Stoneley M; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., MacFarlane M; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom., Fischer PM; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Hirst J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom., Kellam B; School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Willis AE; MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom.

Publikováno v: ELife [Elife] 2020 May 20; Vol. 9. Date of Electronic Publication: 2020 May 20.