Zobrazeno 1 - 10
of 811
pro vyhledávání: '"Stephen. R. Bloom"'
Autor:
Tatiana Lopes, David CD. Hope, Jose M. Ramos-Pittol, Anna Curtis, Jed V. Shrewsbury, Iona Davies, Zijing Zhou, Alessandro Sardini, James S. Minnion, Dirk Dormann, Gavin A. Bewick, Kevin G. Murphy, David Carling, Stephen R. Bloom, Tricia MM. Tan, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102024- (2024)
Objective: Glucagon has long been proposed as a component of multi-agonist obesity therapeutics due to its ability to induce energy expenditure and cause weight loss. However, chronic glucagon-receptor agonism has been associated with a reduction in
Externí odkaz:
https://doaj.org/article/d0ac3e309a1b4c52b8fc5d7efd834e06
Autor:
Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116888- (2024)
Objectives: Co-agonists at the glucagon-like peptide-1 and glucagon receptors (GLP1R/GCGR) show promise as treatments for metabolic dysfunction-associated steatotic liver disease (MASLD). Although most co-agonists to date have been heavily GLP1R-bias
Externí odkaz:
https://doaj.org/article/7c277ce7faa84cd98085788d7067ad56
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Autor:
Aldara Martin Alonso, Simon C. Cork, Phyllis Phuah, Benjamin Hansen, Mariana Norton, Sijing Cheng, Xiang Xu, Kinga Suba, Yue Ma, Georgina KC. Dowsett, John A. Tadross, Brian YH. Lam, Giles SH. Yeo, Herbert Herzog, Stephen R. Bloom, Myrtha Arnold, Walter Distaso, Kevin G. Murphy, Victoria Salem
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101895- (2024)
Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its the
Externí odkaz:
https://doaj.org/article/8ca434c5412d4079a5b6bb6f4eff13e9
Autor:
Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent. As such, a better understanding o
Externí odkaz:
https://doaj.org/article/8c5c2844790d4fd68305731ce059ecb1
Autor:
Emma Rose McGlone, T. Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen R. Bloom, Mark S.P. Sansom, Tricia Tan, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101530- (2022)
Structured abstract: Objective: To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods: We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP product
Externí odkaz:
https://doaj.org/article/30118452e1cf4e4dad65c30c5ab019ba
Autor:
Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101296- (2021)
Objectives: Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of this study were to investigate the effects of RAMP2 on GCGR trafficking and si
Externí odkaz:
https://doaj.org/article/260c126240254cdf851adc98b9aeadbb
Autor:
Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101242- (2021)
Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating t
Externí odkaz:
https://doaj.org/article/81eb48b9c1554fad855b7b0e36385ffc
Autor:
Preeshila Behary, Haya Alessimii, Alexander D. Miras, George Tharakan, Kleopatra Alexiadou, Madhawi M. Aldhwayan, Sanjay Purkayastha, Krishna Moorthy, Ahmed R. Ahmed, Stephen R. Bloom, Tricia M. Tan
Publikováno v:
Diabetes, Obesity and Metabolism. 25:1731-1739
Aims To investigate whether the elevation in postprandial concentrations of the gut hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM) and peptide YY (PYY) accounts for the beneficial changes in food preferences, sweet taste function and e
Autor:
Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100991- (2020)
Objective: The objective of this study was to determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy, and appetite suppression. Methods: In
Externí odkaz:
https://doaj.org/article/6622263a11a0409ea4a255d09f36f3b7
Autor:
Kleopatra Alexiadou, Joyceline Cuenco, Nicolai Jacob Wewer Albrechtsen, Ibiyemi Ilesanmi, Anna Kamocka, George Tharakan, Preeshila Behary, Paul R Bech, Ahmed R Ahmed, Sanjay Purkayastha, Robert Wheller, Matthieu Fleuret, Stephen R Bloom, Bernard Khoo, Tricia M-M Tan
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
IntroductionHyperglucagonemia is a key pathophysiological driver of type 2 diabetes. Although Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for diabetes, it is presently unclear how surgery alters glucagon physiology. The aim of thi
Externí odkaz:
https://doaj.org/article/61cbc49657ec4f6290ed4fbd8742c181