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pro vyhledávání: '"Stephen William Rafferty"'
Autor:
Stephen William Rafferty, Greg A. Erickson, Richard T. Matsuoka, James C. Wisowaty, Barry R. Sickles, Matthew J. Sharp, Jiasheng Guo, Russ N. Fitzgerald
Publikováno v:
The Journal of organic chemistry. 71(21)
An efficient synthesis of 2-{4-[({4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)thio]phenoxy}-2-methylpropanoic acid (1), a potent PPARpan agonist, is described. The seven-step synthesis, which af
Autor:
Timothy M. Willson, Stephen William Rafferty, James D. Joseph, Delita Arnelle Dye, Erin L. Anderson, Philip Stewart Turnbull, Dmitri Kazmin, Andrea B. Sherk, Daju Fan, Dalia Juzumiene, Xiang Deng, Donald P. McDonnell, Ching-Yi Chang, John D. Norris, Huaxia Cui
Publikováno v:
Chemistry & Biology. (4):452-460
SummaryThe pharmacological activity of different nuclear receptor ligands is reflected by their impact on receptor structure. Thus, we asked whether differential presentation of protein-protein interaction surfaces on the androgen receptor (AR), a su