Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Stephen Wanaski"'
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Oral toxicity of vigabatrin in immature rats: Characterization of intramyelinic edema
Autor: Ihor Bekersky, Stephen D. Collins, Dwain Tolbert, Reid Patterson, Bernard S Jortner, Stephen Wanaski, Stephen M. Sagar, Mark Walzer, Robert H. Garman
Publikováno v: NeuroToxicology. 32:963-974
Two toxicologic studies of vigabatrin were conducted with immature Sprague Dawley rats to characterize intramyelinic edema (IME) formation and assess potential impact on behavioral measures. Study 1 was a dosage-ranging characterization of overall to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78df7b8864094a2ddfd8d11437038eb7
https://doi.org/10.1016/j.neuro.2011.03.014
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4
Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target
Autor: Aida Habtezion, Stephen D. Collins, Raymond Kwan, Alice L. Yang, Eugene C. Butcher, Maureen Morgan, M. Bishr Omary, Ehsaan Akhtar, Ahmad Kamal, Stephen Wanaski
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 300:G12-G20
Heme oxygenase-1 (HO-1) induction by hemin or Panhematin protects against experimental pancreatitis. As a preclinical first step toward determining whether HO-1 upregulation is a viable target in acute pancreatitis (AP) patients, we tested the hypoth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a064a90708df374f7d71b4e3d650a6b
https://doi.org/10.1152/ajpgi.00231.2010
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5
Panhematin provides a therapeutic benefit in experimental pancreatitis
Autor: Stephen D. Collins, Raymond Kwan, M. Bishr Omary, Eugene C. Butcher, Stephen Wanaski, David K. Stevenson, Ehsaan Akhtar, Aida Habtezion, Ronald J. Wong
Publikováno v: Gut. 60:671-679
Background and aim Acute pancreatitis (AP) can result in pancreatic necrosis and inflammation, with subsequent multi-organ failure. AP is associated with increased neutrophil recruitment and a rise in pro-inflammatory cytokines such as TNFα. Pretrea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896badad0ef85c7baf255e8a052c6d4d
https://doi.org/10.1136/gut.2010.217208
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6
Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260
Autor: Stephen Wanaski, Stephen M. Collins, Edward L. LeCluyse, Alison H. Harrill, Paul B. Watkins, John M. Cullen, Lakshmi Ramanathan, Yu Ho, Kelly Rose, John S. Eaddy
Publikováno v: Toxicology and applied pharmacology. 277(2)
NP260 was designed as a first-in-class selective antagonist of α4-subtype GABAA receptors that had promising efficacy in animal models of pain, epilepsy, psychosis, and anxiety. However, development of NP260 was complicated following a 28-day safety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e67d7eefdec2268e14151958eb3a5ca
https://pubmed.ncbi.nlm.nih.gov/24699182
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