Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephen W. Scally"'
Autor:
Tony Triglia, Stephen W. Scally, Benjamin A. Seager, Michał Pasternak, Laura F. Dagley, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. The aspartic p
Externí odkaz:
https://doaj.org/article/26c55b01bd7d4a168188f7b3c4ab9d70
Autor:
Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann, Rajagopal Murugan, Jana Lossin, Katherine Prieto, Anna Obraztsova, Nina Lobeto, Blandine Franke-Fayard, Chris J. Janse, Celia Lebas, Nicolas Collin, Spela Binter, Paul Kellam, Elena A. Levashina, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract The development of an effective and durable vaccine remains a central goal in the fight against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites and the target of the only licensed Plasmodium falciparum (Pf
Externí odkaz:
https://doaj.org/article/e21e8d2652bd4aaba4120441ac9e5abb
Autor:
Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann, Rajagopal Murugan, Jana Lossin, Katherine Prieto, Anna Obraztsova, Nina Lobeto, Blandine Franke-Fayard, Chris J. Janse, Celia Lebas, Nicolas Collin, Spela Binter, Paul Kellam, Elena A. Levashina, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b04564d582c142d78add34d9a8e7e92b
Autor:
Brandon McLeod, Kazutoyo Miura, Stephen W. Scally, Alexandre Bosch, Ngan Nguyen, Hanjun Shin, Dongkyoon Kim, Wayne Volkmuth, Sebastian Rämisch, Jessica A. Chichester, Stephen Streatfield, Colleen Woods, William R. Schief, Daniel Emerling, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Pfs25 is a transmission-blocking vaccine candidate for Plasmodium. Here, McLeod et al. analyze the antibody response to Pfs25 in sera from a clinical trial evaluating a Pfs25 vaccine candidate, identify a potent transmission-blocking antibody and det
Externí odkaz:
https://doaj.org/article/67758bcac9e4447fab4577c5f6b5c7a0
Autor:
Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura, Qi Liang, Sean Carroll, Sini Reponen, Ngan Nguyen, Eldar Giladi, Sebastian Rämisch, Vidadi Yusibov, Allan Bradley, Franck Lemiale, William R. Schief, Daniel Emerling, Paul Kellam, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicit
Externí odkaz:
https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d
Autor:
Stephen W. Scally, Tony Triglia, Cindy Evelyn, Benjamin A. Seager, Michał Pasternak, Pailene S. Lim, Julie Healer, Niall D. Geoghegan, Amy Adair, Wai-Hong Tham, Laura F. Dagley, Kelly L. Rogers, Alan F. Cowman
Publikováno v:
Nature Microbiology. 7:2039-2053
The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an essential step in this process involves the ligand PfRh5, which forms a complex with cysteine-rich protective antigen (CyRPA) and Pf
Autor:
Iga Kucharska, Špela Binter, Rajagopal Murugan, Stephen W. Scally, Julia Ludwig, Katherine Prieto, Elaine Thai, Giulia Costa, Kan Li, Gillian Q. Horn, Yevel Flores-Garcia, Alexandre Bosch, Taylor Sicard, John L. Rubinstein, Fidel Zavala, S. Moses Dennison, Georgia D. Tomaras, Elena A. Levashina, Paul Kellam, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
PLoS Pathogens, 18(11). PUBLIC LIBRARY SCIENCE
PLoS Pathogens
PLoS Pathogens
Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central repeating NANP motifs; some of the most potent anti-infective antibodies against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3a1af0c36211921290fa6a9b8b3b7
https://hdl.handle.net/1887/3567044
https://hdl.handle.net/1887/3567044
Autor:
Stephen W, Scally, Brandon, McLeod, Alexandre, Bosch, Kazutoyo, Miura, Qi, Liang, Sean, Carroll, Sini, Reponen, Ngan, Nguyen, Eldar, Giladi, Sebastian, Rämisch, Vidadi, Yusibov, Allan, Bradley, Franck, Lemiale, William R, Schief, Daniel, Emerling, Paul, Kellam, C Richter, King, Jean-Philippe, Julien
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by Anopheles mosquitoes during blood meals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::279abaecce8e54bb2d05b0b0f232f200
http://hdl.handle.net/10044/1/70143
http://hdl.handle.net/10044/1/70143
Autor:
Juliet A. Gerrard, Malcolm R. Alderton, Stephen W. Scally, Con Dogovski, Craig A. Hutton, Nicole L. Taylor, Michael D. W. Griffin, Sarah C. Atkinson, Renwick C. J. Dobson, Jarrod E. Voss, Matthew A. Perugini, Michael W. Parker
Publikováno v:
Journal of Biological Chemistry. 285:5188-5195
Bacillus anthracis is a gram-positive spore-forming bacterium that causes anthrax. With the increased threat of anthrax in biowarfare, there is an urgent need to characterize new antimicrobial targets from B. anthracis. One such target is dihydrodipi
Autor:
Kenji Chamoto, Tingxi Guo, Stephen W. Scally, Yuki Kagoya, Mark Anczurowski, Chung-Hsi Wang, Muhammed A. Rahman, Kayoko Saso, Marcus O. Butler, Priscilla P. L. Chiu, Jean-Philippe Julien, Naoto Hirano
Publikováno v:
The Journal of Immunology. 198:3757-3757