Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephen W. Raso"'
Autor:
Yin Luo, Jason C. Rouse, Stephen W. Raso, Judith Gallant, Zhaojiang Lu, Yasuko Mabuchi, Colleen Steinmeyer, Clifford Entrican
Publikováno v:
mAbs. 9:916-926
Recombinant protein therapeutics have become increasingly useful in combating human diseases, such as cancer and those of genetic origin. One quality concern for protein therapeutics is the content and the structure of the aggregated proteins in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef724cf9366b50b466485909f92cf9a
https://doi.org/10.1080/19420862.2017.1331803
https://doi.org/10.1080/19420862.2017.1331803
Autor:
Sandeep Kumar, Annaliesa S. Anderson, Stephen W. Raso, Gary W. Zlotnick, Kathrin U. Jansen, Emilia Byrne, Yin Luo, Vidunas Eugene Joseph, Robert L. Dufield, Jason C. Rouse, Michael R. Schlittler, Donald Stano, Herbert A. Runnels, Thomas Gore, Elena G. Novikova, Olga V. Friese, Lakshmi Khandke, Ann Aulabaugh
Publikováno v:
The AAPS Journal. 18:1562-1575
Trumenba (bivalent rLP2086) is a vaccine licensed for the prevention of meningococcal meningitis disease caused by Neisseria meningitidis serogroup B (NmB) in individuals 10-25 years of age in the USA. The vaccine is composed of two factor H binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a31574b37e4c0d2379c3a11a6578ad4
https://doi.org/10.1208/s12248-016-9979-x
https://doi.org/10.1208/s12248-016-9979-x
Autor:
Rosemary Lawrence-Henderson, Yulia Vugmeyster, Beth A. Leary, Christopher S Mahoney, Stephane Olland, Alison Joyce, Clifford Entrican, Xin Xu, Stephen W. Raso, Martin Hegen, Himakshi Patel
Publikováno v:
Bioconjugate Chemistry. 23:1452-1462
Covalent attachment of poly(ethylene glycol) (PEG) to therapeutic proteins has been used to prolong in vivo exposure of therapeutic proteins. We have examined pharmacokinetic, biodistribution, and biophysical profiles of three different tumor necrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c84fc11da950cca96ed9415d03a94c
https://doi.org/10.1021/bc300066a
https://doi.org/10.1021/bc300066a
Autor:
Patricia L. Clark, Stephen W. Raso, George J. Thomas, Jonathan King, Cameron Haase-Pettingell
Publikováno v:
Journal of Molecular Biology. 307:899-911
Very little is known about the character or functional relevance of hydrogen-bonded cysteine sulfhydryl (S-H) groups in proteins. The Raman S-H band is a unique and sensitive probe of the local S-H environment. Here, we report the use of Raman spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d05f94093c9c018538852e43549b3018
https://doi.org/10.1006/jmbi.2001.4476
https://doi.org/10.1006/jmbi.2001.4476
Autor:
Tanya Shang, Yin Luo, Jason C. Rouse, Stephen W. Raso, Thomas J. Porter, Chee-Keng Ng, John Steckert, Tatjana Matejic, Brian Nunnally
Appropriate and complete analysis and characterization of biopharmaceutical proteins are important to the control of their safety, purity, potency, stability, and overall quality. This chapter reviews the methodologies that are used to characterize i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6736f9654517223b0264d81562092121
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
Publikováno v:
mAbs. 1(5)
The in vitro binding of monomeric, dimeric and multimeric forms of monoclonal IgG1 molecules, designated mAb1 and mAb2, to the extracellular domains of Fcgamma receptors RI, RIIA and RIIIB were investigated using a surface plasmon resonance (SPR) bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc0718be219613e425d442c4fd3c9f6
https://pubmed.ncbi.nlm.nih.gov/20065648
https://pubmed.ncbi.nlm.nih.gov/20065648
Autor:
Lisa Stuart, Stephen W. Raso, Cameron Haase-Pettingell, Scott Betts, Jonathan King, Anne S. Robinson
Publikováno v:
Protein science : a publication of the Protein Society. 10(2)
The predominantly beta-sheet phage P22 tailspike adhesin contains eight reduced cysteines per 666 residue chain, which are buried and unreactive in the native trimer. In the pathway to the native trimer, both in vivo and in vitro transient interchain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272f3be34be7b0e82287e54ca5d91910
https://pubmed.ncbi.nlm.nih.gov/11266625
https://pubmed.ncbi.nlm.nih.gov/11266625