Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephen W. Horgan"'
Autor:
David W. Freund, Mark Webster, Timothy A. Ayers, Timothy J. N. Watson, David L. Wenstrup, Stephen W. Horgan, Nik Shah, James P. Carey
Publikováno v:
Organic Process Research & Development. 7:521-532
A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c1839c17be21d1f88b24d9482e980c3
https://doi.org/10.1021/op020225p
https://doi.org/10.1021/op020225p
Autor:
Farr Robert A, Edward W. Huber, Ramnik S. Shah, Richard A. Schnettler, Christian T. Goralski, Mark E. Webster, C. Richard Nevill, Bruce Baron, Timothy James-Norman Watson, Phillip L. Nyce, and Cynthia L. Rand, Boyd L. Harrison, Rajesh K. Mishra, Stephen W. Horgan, Franz J. Weiberth
Publikováno v:
Organic Process Research & Development. 4:477-487
MDL 103371 is a N-methyl-d-aspartate (NMDA)-type glycine receptor antagonist for the potential treatment of stroke. Evaluation of five different synthetic routes, which included Stille, Suzuki, enol ether, Knoevenagel, and the Mukaiyama coupling reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b38533a17e41e232194113e866931b2
https://doi.org/10.1021/op000286s
https://doi.org/10.1021/op000286s
Autor:
Neal J. Fetner, Robert J. Cregge, Mark E. Webster, and Mark A. Nitz, Michael A. DesJardin, David W. Freund, David W. Burkhouse, Hoops John F, Richard E. Donaldson, Robert C. Clouse, Stephen W. Horgan, Gerald P. Heinrich, Daniel R. Henton, J. Russell McConnell, Robert T. Keaten, Christian T. Goralski, Kathy P. Barton, Michael E. LeTourneau, and Alexey Margolin, Sandra K. Stolz-Dunn
Publikováno v:
Organic Process Research & Development. 3:241-247
MDL 28,726 is a key intermediate in the synthesis of the ACE inhibitors MDL 27,210A and MDL 100,240. An efficient nine-step synthesis of this tricyclic acid, which has three chiral centers, was developed beginning with 3,4-dihydro-2H-pyran. A key ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddfb6cb0a5ed6223ba014b4a36361bac
https://doi.org/10.1021/op970125x
https://doi.org/10.1021/op970125x
Autor:
Julie L. Geary, Melinda A. Correll, J. Chuck Poole, Xiao-Gao Liu, Larry D. Bratton, Fred E. Boyer, Thomas N. Thompson, Teng-Man Chen, Arun K. Mandagere, Bryan K. Jones, Kin-Kai Hwang, Mark E. Webster, Robert W. Knippenberg, Maynard George D, Stephen W. Horgan, Deborah E. Logan, Tieu-Binh Le, Kudlacz Elizabeth M, David L. Wenstrup, Burkholder Timothy P, Raymond S. Gross, David W. Freund
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2531-2536
We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors.1 Here we report the synthesis and structure-activity relationships for a series of analogs of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a5ed5f48c9a57f6ec7d3becd618960
https://doi.org/10.1016/s0960-894x(97)10013-0
https://doi.org/10.1016/s0960-894x(97)10013-0
Autor:
Tieu-Binh Le, S. A. Shatzer, Burkholder Timothy P, Maynard George D, Stephen W. Horgan, Kudlacz Elizabeth M, Robert W. Knippenberg, Mark E. Webster
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:951-956
We have synthesized and identified MDL 105,212, a non-peptide tachykinin receptor antagonist that has high affinity for human NK1 (IC50=3.11 nM) and NK2 (IC50=8.40 nM) receptors. The chemical synthesis of MDL 105,212 and the SAR of a series of racemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a9e30e56ef1cbb6a0f64fa0e49b8daa
https://doi.org/10.1016/0960-894x(96)00148-5
https://doi.org/10.1016/0960-894x(96)00148-5
Autor:
S. A. Shatzer, Burkholder Timothy P, Robert W. Knippenberg, Tieu-Binh Le, Maynard George D, Mark E. Webster, Stephen W. Horgan, Kudlacz Elizabeth M
Publikováno v:
ChemInform. 27
We have synthesized and identified MDL 105,212, a non-peptide tachykinin receptor antagonist that has high affinity for human NK1 (IC50=3.11 nM) and NK2 (IC50=8.40 nM) receptors. The chemical synthesis of MDL 105,212 and the SAR of a series of racemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::452d12977aa32e192e29d9ae4ea4c728
https://doi.org/10.1002/chin.199634141
https://doi.org/10.1002/chin.199634141
Autor:
Stephen W. Horgan, et al. et al.
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c91d66b35fda220340bd023e926cfd5
https://doi.org/10.1002/chin.199945195
https://doi.org/10.1002/chin.199945195
Publikováno v:
Chemical Reviews. 71:229-246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2949a30d348b77370d2770af20163e
https://doi.org/10.1021/cr60270a005
https://doi.org/10.1021/cr60270a005
Publikováno v:
Tetrahedron Letters. 11:4347-4350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b22cf19634344551abd6e3786a64231
https://doi.org/10.1016/s0040-4039(00)89482-4
https://doi.org/10.1016/s0040-4039(00)89482-4
Publikováno v:
Tetrahedron Letters. 13:1789-1792
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250f6a4e9cfaf4a571d85e0d7684734a
https://doi.org/10.1016/s0040-4039(01)85269-2
https://doi.org/10.1016/s0040-4039(01)85269-2