Výsledky vyhledávání - "Stephen W. Holman"

Akademický článek

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

Autor: Ibrahim E. Elsemman, Angelica Rodriguez Prado, Pranas Grigaitis, Manuel Garcia Albornoz, Victoria Harman, Stephen W. Holman, Johan van Heerden, Frank J. Bruggeman, Mark M. M. Bisschops, Nikolaus Sonnenschein, Simon Hubbard, Rob Beynon, Pascale Daran-Lapujade, Jens Nielsen, Bas Teusink

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Metabolically active organelles compete for cytosolic space and resources during metabolism rewiring. Here, the authors develop a computational model of yeast metabolism and resource allocation to predict condition- and compartment-specific proteome

Externí odkaz: https://doaj.org/article/c9208717b9f645ce8b0fdca3215e4a74

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Akademický článek

Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription

Autor: Francesco Lanucara, Connie Lam, Jelena Mann, Tom P. Monie, Stefano A. P. Colombo, Stephen W. Holman, James Boyd, Manohar C. Dange, Derek A. Mann, Michael R. H. White, Claire E. Eyers

Publikováno v: Open Biology, Vol 6, Iss 7 (2016)

The NF-κB signalling module controls transcription through a network of protein kinases such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including RelA/p65. Phosphorylation of the NF-κB subunits is critical for dic

Externí odkaz: https://doaj.org/article/a34c79319d2c491f982226bd453d9392

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Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

Autor: Garcia Albornoz M, Stephen W. Holman, Pranas Grigaitis, Nikolaus Sonnenschein, Pascale Daran-Lapujade, Ibrahim E. Elsemman, Frank J. Bruggeman, Bisschops Mmm, Bas Teusink, van Heerden J, Rodrigues Prado A, Robert J. Beynon, Harman, Jens Nielsen, Simon J. Hubbard

Publikováno v: Nature communications
Elsemman, I E, Rodriguez Prado, A, Grigaitis, P, Garcia Albornoz, M, Harman, V, Holman, S W, van Heerden, J, Bruggeman, F J, Bisschops, M M M, Sonnenschein, N, Hubbard, S, Beynon, R, Daran-Lapujade, P, Nielsen, J & Teusink, B 2022, ' Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies ', Nature Communications, vol. 13, 801, pp. 1-12 . https://doi.org/10.1038/s41467-022-28467-6
Nature Communications, 13(1)
Elsemman, I E, Rodriguez Prado, A, Grigaitis, P, Garcia Albornoz, M, Harman, V, Holman, S W, van Heerden, J, Bruggeman, F J, Bisschops, M M M, Sonnenschein, N, Hubbard, S, Beynon, R, Daran-Lapujade, P, Nielsen, J & Teusink, B 2022, ' Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies ', Nature Communications, vol. 13, no. 1, 801 . https://doi.org/10.1038/s41467-022-28467-6
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
bioRxiv
Nature Communications, 13:801, 1-12. Nature Publishing Group

When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as resource re-allocation under cellular constraints. Eukaryal cells contain metabolically active o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73a2837bd4e265ea915b62531f555a1
http://livrepository.liverpool.ac.uk/3149305/1/s41467-022-28467-6.pdf

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