Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stephen W. Ashurst"'
Autor:
Pauline Galluccio, Jenny Phillips, Orla McAlinden, Sue Cooper, Tessa Shellens, Jane L Fox, Stephen W Ashurst, Valerie Gorton, Tom V Ward, Kate Davies, Mary Scott
Publikováno v:
British Journal of Nursing. 4:652-657
Autor:
Gerald M. Cohen, Stephen W. Ashurst
Publikováno v:
International Journal of Cancer. 28:387-392
The extent of reaction of benzo(a)pyrene with DNA and the formation of benzo(a)pyrene-deoxyribonucleoside adducts in the skins of male Wistar rats were investigated. Following topical application of benzo(a)pyrene (200 nmoles), binding reached a maxi
Autor:
Stephen W. Ashurst, Gerald M. Cohen
Publikováno v:
Chemico-biological interactions. 29(1)
Benzo[alpha]pyrene is metabolised by isolated viable hepatocytes from both untreated and 3-methylcholanthrene pretreated rats to reactive metabolites which covalently bind to DNA. The DNA from the hepatocytes was isolated, purified and enzymically hy
Autor:
Gerald M. Cohen, Stephen W. Ashurst
Publikováno v:
International journal of cancer. 27(3)
The hydrocarbon-deoxyribonucleoside adducts formed in mouse skin DNA have been determined following topical application of an initiating dose of benzo(a)pyrene to Swiss mice, a strain shown to be susceptible to benzo(a)pyrene-induced skin carcinogene
Autor:
Stephen W. Ashurst, Gerald M. Cohen
Publikováno v:
Carcinogenesis. 3(3)
The formation of DNA-bound products from benzo [a]-pyrene was studied using metabolic activation systems of widely differing cellular and structural integrity. The nature of the benzo [a] pyrene-metabolite-deoxyribonucleoside adducts formed was marke