Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Stephen W White"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129807 (2015)
The anti-apoptotic protein survivin is highly expressed in most human cancer cells, but has very low expression in normal differentiated cells. Thus survivin is considered as an attractive cancer drug target. Herein we report the design and synthesis
Externí odkaz:
https://doaj.org/article/f58fc663d31c4b91873388e7f51a84e1
Autor:
Rebecca M DuBois, P Jake Slavish, Brandi M Baughman, Mi-Kyung Yun, Ju Bao, Richard J Webby, Thomas R Webb, Stephen W White
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002830 (2012)
Emerging influenza viruses are a serious threat to human health because of their pandemic potential. A promising target for the development of novel anti-influenza therapeutics is the PA protein, whose endonuclease activity is essential for viral rep
Externí odkaz:
https://doaj.org/article/30fcbdf37e594ae99327103b81eb13cd
Autor:
Rebecca M DuBois, Hassan Zaraket, Muralidhar Reddivari, Richard J Heath, Stephen W White, Charles J Russell
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002398 (2011)
Highly pathogenic avian influenza viruses of the H5N1 subtype continue to threaten agriculture and human health. Here, we use biochemistry and x-ray crystallography to reveal how amino-acid variations in the hemagglutinin (HA) protein contribute to t
Externí odkaz:
https://doaj.org/article/e09d4bebb97d49c48a30c6137ade9502
Autor:
Charles W Pemble, Perdeep K Mehta, Smriti Mehra, Zhenmei Li, Amanda Nourse, Richard E Lee, Stephen W White
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14165 (2010)
The 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) enzymes catalyze sequential metabolic reactions in the folate biosynthetic pathway of bacteria and lower eukaryotes. Both enzymes represent validated t
Externí odkaz:
https://doaj.org/article/81a0f4d32db84ce4a7ecafd3a78fd2c5
Autor:
José M Aguilar-Yáñez, Roberto Portillo-Lara, Gonzalo I Mendoza-Ochoa, Sergio A García-Echauri, Felipe López-Pacheco, David Bulnes-Abundis, Johari Salgado-Gallegos, Itzel M Lara-Mayorga, Yenny Webb-Vargas, Felipe O León-Angel, Ramón E Rivero-Aranda, Yuriana Oropeza-Almazán, Guillermo M Ruiz-Palacios, Manuel I Zertuche-Guerra, Rebecca M DuBois, Stephen W White, Stacey Schultz-Cherry, Charles J Russell, Mario M Alvarez
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11694 (2010)
The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, exp
Externí odkaz:
https://doaj.org/article/92879a1591914b66b9e8aa1c5572aabf
Autor:
Satyanarayana Pochampally, Kelli L. Hartman, Rui Wang, Jiaxing Wang, Mi-Kyung Yun, Keyur Parmar, Hyunseo Park, Bernd Meibohm, Stephen W. White, Wei Li, Duane D. Miller
Publikováno v:
ACS Pharmacology & Translational Science. 6:526-545
Autor:
Chitra Subramanian, Matthew W. Frank, Rajendra Tangallapally, Mi‐Kyung Yun, Stephen W. White, Richard E. Lee, Charles O. Rock, Suzanne Jackowski
Publikováno v:
Journal of Inherited Metabolic Disease. 46:28-42
Propionic acidemia (PA, OMIM 606054) is a devastating inborn error of metabolism arising from mutations that reduce the activity of the mitochondrial enzyme propionyl-CoA carboxylase (PCC). The defects in PCC reduce the concentrations of nonesterifie
Autor:
Philip M. Potter, Anang A. Shelat, Stephen W. White, R. Kiplin Guy, Daniel Savic, Taosheng Chen, Martine F. Roussel, Marie Morfouace, Richard E. Lee, Jun Yang, Vincent A. Boyd, Nagakumar Bharatham, Brandon M. Young, Jeanine E. Price, Jonathan A. Low, Kevin W. Freeman, Rachelle R. Olsen, William R. Shadrick, Zhenmei Li, Geoffrey Neale, Sourav Das, M. Brett Waddell, Michele Connelly, Sergio C. Chai, Barbara Jonchere, Nancy E. Martinez, Lyudmila Tsurkan, Mi-Kyung Yun, Liying Chi, P. Jake Slavish
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5d71e4e32bd0d5208d4d9130ecd2d2
https://doi.org/10.1158/0008-5472.c.6511882.v1
https://doi.org/10.1158/0008-5472.c.6511882.v1
Autor:
Richard E. Lee, Jake Slavish, Brandon Young, Lei Yang, Sergio C. Chai, Marcus Fischer, Taosheng Chen, Zhenmei Li, Stephen W. White, Stanley Nithianantham, Jaeki Min, Gisele Nishiguchi, Seung Wook Yang, Patrick Ryan Potts, Marisa Actis, Shalandus H. Garrett, Jamie Jarusiewicz, Sourav Das, Martine F. Roussel, Barbara Jonchere, Anand Mayasundari, Yong Li, Mi-Kyung Yun, Xiang Fu, Fatemeh Keramatnia, Anang A. Shelat, Zoran Rankovic
Publikováno v:
Angew Chem Int Ed Engl
Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis-targeting chimera (PROTAC) approaches, owing to favorable drug-like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to b