Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stephen W Hartley"'
Autor:
Jung Kim, Danielle M Karyadi, Stephen W Hartley, Bin Zhu, Mingyi Wang, Dongjing Wu, Lei Song, Gregory T Armstrong, Smita Bhatia, Leslie L Robison, Yutaka Yasui, Brian Carter, Joshua N Sampson, Neal D Freedman, Alisa M Goldstein, Lisa Mirabello, Stephen J Chanock, Lindsay M Morton, Sharon A Savage, Douglas R Stewart
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280951 (2023)
The use of publicly available sequencing datasets as controls (hereafter, "public controls") in studies of rare variant disease associations has great promise but can increase the risk of false-positive discovery. The specific factors that could cont
Externí odkaz:
https://doaj.org/article/642131f437b34ce39db4400b1058a400
Autor:
Lindsay M. Morton, Olivia W. Lee, Danielle M. Karyadi, Tetiana I. Bogdanova, Chip Stewart, Stephen W. Hartley, Charles E. Breeze, Sara J. Schonfeld, Elizabeth K. Cahoon, Vladimir Drozdovitch, Sergii Masiuk, Mykola Chepurny, Liudmyla Yu Zurnadzhy, Jieqiong Dai, Marko Krznaric, Meredith Yeager, Amy Hutchinson, Belynda D. Hicks, Casey L. Dagnall, Mia K. Steinberg, Kristine Jones, Komal Jain, Ben Jordan, Mitchell J. Machiela, Eric T. Dawson, Vibha Vij, Julie M. Gastier-Foster, Jay Bowen, Kiyohiko Mabuchi, Maureen Hatch, Amy Berrington de Gonzalez, Gad Getz, Mykola D. Tronko, Gerry A. Thomas, Stephen J. Chanock
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Childhood radioactive iodine exposure from the Chornobyl accident increased papillary thyroid carcinoma (PTC) risk. While cervical lymph node metastases (cLNM) are well-recognized in pediatric PTC, the PTC metastatic process and potential ra
Externí odkaz:
https://doaj.org/article/43b4a3f2d4b34656b884b3b550e5f0f9
Autor:
Stephen W Hartley, James C Mullikin, David C Klein, Morgan Park, NISC Comparative Sequencing Program, Steven L Coon
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163590 (2016)
Alternative isoform regulation (AIR) vastly increases transcriptome diversity and plays an important role in numerous biological processes and pathologies. However, the detection and analysis of isoform-level differential regulation is difficult, par
Externí odkaz:
https://doaj.org/article/64ce8b535d2849c4aaddd1197f2e6551
Autor:
Stephen W Hartley, Steven L Coon, Luis E Savastano, James C Mullikin, NISC Comparative Sequencing Program, Cong Fu, David C Klein
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137548 (2015)
The term neurotranscriptomics is used here to describe genome-wide analysis of neural control of transcriptomes. In this report, next-generation RNA sequencing was using to analyze the effects of neonatal (5-days-of-age) surgical stimulus deprivation
Externí odkaz:
https://doaj.org/article/1f9760fabe7d41b8853daefb4e5cea8e
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated w
Externí odkaz:
https://doaj.org/article/136e7705f132446e91a89837ca43031c
Autor:
Jacqueline N Milton, Paola Sebastiani, Nadia Solovieff, Stephen W Hartley, Pallav Bhatnagar, Dan E Arking, Daniel A Dworkis, James F Casella, Emily Barron-Casella, Christopher J Bean, W Craig Hooper, Michael R DeBaun, Melanie E Garrett, Karen Soldano, Marilyn J Telen, Allison Ashley-Koch, Mark T Gladwin, Clinton T Baldwin, Martin H Steinberg, Elizabeth S Klings
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34741 (2012)
Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bi
Externí odkaz:
https://doaj.org/article/e53a001de2c94b03abd90caee3295980
Autor:
Paola Sebastiani, Nadia Solovieff, Andrew T Dewan, Kyle M Walsh, Annibale Puca, Stephen W Hartley, Efthymia Melista, Stacy Andersen, Daniel A Dworkis, Jemma B Wilk, Richard H Myers, Martin H Steinberg, Monty Montano, Clinton T Baldwin, Josephine Hoh, Thomas T Perls
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29848 (2012)
Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association
Externí odkaz:
https://doaj.org/article/b1f6a912b0e84236b924f595f47ff04b
Autor:
Bin Zhu, Kristine Jones, Eric Karlins, Gregory T. Armstrong, Stephen W. Hartley, Belynda Hicks, Byron S. Sigel, Jeremy A. Miller, Stephen J. Chanock, Rita E. Weathers, Joshua N. Sampson, Yutaka Yasui, Smita Bhatia, Lucie M. Turcotte, Leslie L. Robison, Diana M. Merino, Margaret A. Tucker, Lindsay M. Morton, Megan N. Frone, Michael Arnold, Wendy M. Leisenring, Casey L. Dagnall, Joseph P. Neglia, Meredith Yeager, Danielle M. Karyadi, Susan A. Smith, Amy Berrington de Gonzalez, Rebecca M. Howell
Publikováno v:
JCO Precis Oncol
PURPOSE Radiotherapy for childhood cancer is associated with elevated subsequent neoplasm (SN) risk, but the contribution of rare variants in DNA damage response and radiation sensitivity genes to SN risk is unknown. PATIENTS AND METHODS We conducted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac99fbaf96ae490d29462f02ea408363
https://doi.org/10.1200/po.20.00141
https://doi.org/10.1200/po.20.00141
Autor:
Olivia W. Lee, Danielle M. Karyadi, Chip Stewart, Tetiana I. Bogdanova, Jieqiong Dai, Stephen W. Hartley, Sara J. Schonfeld, Vidushi Kapoor, Marko Krznaric, Meredith Yeager, Amy Hutchinson, Belynda D. Hicks, Casey L. Dagnall, Julie M. Gastier-Foster, Jay Bowen, Mitchell J. Machiela, Elizabeth K. Cahoon, Kiyohiko Mabuchi, Vladimir Drozdovitch, Sergii Masiuk, Mykola Chepurny, Liudmyla Y. Zurnadzhy, Amy Berrington de González, Gad Getz, Gerry A. Thomas, Mykola D. Tronko, Lindsay M. Morton, Stephen J. Chanock
Publikováno v:
Cancer Research. 82:980-980
Following the Chernobyl nuclear power plant explosion in Ukraine in 1986, increased childhood exposure to radioactive iodine (131I), which occurred primarily through contaminated food sources, has been consistently associated with increased risk of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38fb0de96b86c7a1a0911071919eec0
https://doi.org/10.1158/1538-7445.am2022-980
https://doi.org/10.1158/1538-7445.am2022-980
Autor:
Rohan Hazra, Deborah Kacanek, Shu-Hong Lin, Stephen W. Hartley, Sean S Brummel, Danielle M. Karyadi, Weiyin Zhou, Erin Beilstein-Wedel, Youjin Wang, Ellen G. Chadwick, Stephen J. Chanock, Olivia W. Lee, Bin Zhu, Derek Brown, Eric A. Engels, Miriam C. Poirier, Carmen J. Marsit, Mitchell J. Machiela
Publikováno v:
AIDS
Objective Zidovudine (ZDV) has been extensively used in pregnant women to prevent vertical transmission of HIV but few studies have evaluated potential mutagenic effects of ZDV during fetal development. Design Our study investigated clonal hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52c3e5b2cf8284d31382e7c32026bb6
https://doi.org/10.1097/qad.0000000000002894
https://doi.org/10.1097/qad.0000000000002894