Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Stephen W, Wright"'
Autor:
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/c56070943eee409893dfc8b9a45018c9
Autor:
Stephen W. Wright, Gordon W. Gribble
Publikováno v:
Organic Preparations and Procedures International. :1-4
Publikováno v:
The Journal of Organic Chemistry. 88:4387-4396
Autor:
Chulho Choi, Anthony A. Carlo, Ciarán N. Cronin, Konghua Jing, Daniel W. Kung, Jianhua Liu, Vincent M. Lombardo, Abigail R. Turco, Juxing Yin, Aijia Yu, Stephen W. Wright
Publikováno v:
ACS Medicinal Chemistry Letters. 13:250-256
Autor:
Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, Chulho Choi, Gabriela Dower, Kathleen A. Farley, Margaret Fleming, Andrew Flick, Richard K. Frisbie, Justin Hall, David Hepworth, Hannah Jones, John D. Knafels, Steve Kortum, Frank E. Lovering, John P. Mathias, Sashi Mohan, Paul M. Morgan, Chuenlei Parng, Kevin Parris, Nick Pullen, Franklin Schlerman, John Stansfield, Joseph W. Strohbach, Felix F. Vajdos, Fabien Vincent, Hong Wang, Xiaolun Wang, Robert Webster, Stephen W. Wright
Publikováno v:
Journal of medicinal chemistry. 65(1)
A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe
Autor:
Chulho, Choi, Anthony A, Carlo, Ciarán N, Cronin, Konghua, Jing, Daniel W, Kung, Jianhua, Liu, Vincent M, Lombardo, Abigail R, Turco, Juxing, Yin, Aijia, Yu, Stephen W, Wright
Publikováno v:
ACS Med Chem Lett
[Image: see text] The metabolic oxidation of drug-like small molecules by aldehyde oxidase (AO) has commonly been mitigated through the incorporation of deuterium at the oxidation site. We report that dimethylformamide dimethyl acetal and related com
Autor:
Zhihui Peng, Robert A. Singer, David B. Damon, Lulin Wei, Emma McInturff, Bryan Li, Stephen W. Wright, David Place
Publikováno v:
Organic Process Research & Development. 22:1835-1845
An improved process for the large scale synthesis of 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (1), a candidate currently in clinical develop...
Publikováno v:
The Journal of organic chemistry. 85(23)
In a recent methodological study investigating the synthesis of N-alkoxyazomethine ylides, an unexpected aminal byproduct was generated during our attempt to isolate O-benzyl-N-((trimethylsilyl)methyl)hydroxylamine. After a strategic investigation, s
Publikováno v:
Tetrahedron. 104:132597
Autor:
Dafydd R. Owen, James D. Clark, Xiaojing Yang, Eddine Saiah, Martin Hegen, Brian S. Gerstenberger, Felix Vajdos, Catherine M. Ambler, Li Xing, Alpay Dermenci, Tsung H. Lin, Matthew Merrill Hayward, Raman Sharma, Xin Yang, David W. Lin, John D. Knafels, Eric P. Arnold, Mary-Ellen Banker, Stephen W. Wright, Martin E. Dowty, Brett D. Hollingshead, Andrew Fensome, Susan Fish, Matthew Frank Brown
Publikováno v:
Journal of medicinal chemistry. 63(22)
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, where it pairs with JAK2 or JAK1, respectively. On the basis of human