Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephen V. Straub"'
Publikováno v:
Biological Research, Vol 37, Iss 4, Pp 593-602 (2004)
Calcium release via intracellular Ca2+ release channels is a central event underpinning the generation of numerous, often divergent physiological processes. In electrically non-excitable cells, this Ca2+ release is brought about primarily through act
Externí odkaz:
https://doaj.org/article/e92d6027e99b4039824395d96b906b26
Autor:
Stephen V. Straub, Mark T. Nelson
Publikováno v:
Trends in Cardiovascular Medicine. 17:183-190
In the brain, increased neuronal synaptic activity is accompanied by an increase in local cerebral blood flow that serves to satisfy neuronal metabolic demands. This linkage between neuronal activity and local blood flow has been appreciated for more
Publikováno v:
The Journal of General Physiology
Active neurons communicate to intracerebral arterioles in part through an elevation of cytosolic Ca(2+) concentration ([Ca(2+)](i)) in astrocytes, leading to the generation of vasoactive signals involved in neurovascular coupling. In particular, [Ca(
Publikováno v:
Journal of Biological Chemistry. 279:39485-39494
In salivary acinar cells, intracellular calcium ([Ca(2+)](i)) signaling plays an important role in eliciting fluid secretion through the activation of Ca(2+)-activated ionic conductances. Ca(2+) and cAMP have synergistic effects on fluid secretion su
Autor:
Stephen V. Straub, James Sneyd, David I. Yule, Krasimira Tsaneva-Atanasova, David R. Giovannucci, Jason I.E. Bruce
Publikováno v:
Scopus-Elsevier
We construct a mathematical model of Ca(2+) wave propagation in pancreatic and parotid acinar cells. Ca(2+) release is via inositol trisphosphate receptors and ryanodine receptors that are distributed heterogeneously through the cell. The apical and
Publikováno v:
Journal of General Physiology. 116:547-560
In pancreatic acinar cells, inositol 1,4,5-trisphosphate (InsP3)–dependent cytosolic calcium ([Ca2+]i) increases resulting from agonist stimulation are initiated in an apical “trigger zone,” where the vast majority of InsP3 receptors (InsP3R) a
Publikováno v:
The Chemical Educator. 3:1-16
Iodine adsorbed on a Pd electrode has been shown to catalyze the anodic dissolution of Pd in halide-free acidic solutions. An undergraduate instrumental analysis laboratory experiment has been developed that enables students to use basic electrochemi
Autor:
Stephen V. Straub, Beijing Tan, Catherine E. Trebino, Kimberly A. Coughlan, V. Margaret Jackson, Sylvie Perez, Patricia Cosgrove, Joanne M. Buxton, John M. Kreeger
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 301(2)
Genetic ablation of the voltage-gated potassium channel Kv1.3 improves insulin sensitivity and increases metabolic rate in mice. Inhibition of Kv1.3 in mouse adipose and skeletal muscle is reported to increase glucose uptake through increased GLUT4 t
Autor:
Hélène Girouard, Stephen V. Straub, Paul E. Doetsch, Mark T. Nelson, M. Keith Wilkerson, Rachael M. Hannah
Publikováno v:
American journal of physiology. Cell physiology. 297(3)
Voltage-gated potassium (Kv) channels in vascular smooth muscle cells (VSMC) are critical regulators of membrane potential and vascular tone. These channels exert a hyperpolarizing influence to counteract the depolarizing effects of intraluminal pres
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 292(6)
Myogenic vasoconstriction results from pressure-induced vascular smooth muscle cell depolarization and Ca2+influx via voltage-dependent Ca2+channels, a process that is significantly attenuated by inhibition of protein kinase C (PKC). It was recently