Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Stephen V, Frye"'
Autor:
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformati
Externí odkaz:
https://doaj.org/article/0f5b7e97b6324cda80e7ab7f47fa3f98
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Autor:
Devan J. Shell, Justin M. Rectenwald, Peter H. Buttery, Rebecca L. Johnson, Caroline A. Foley, Shiva K.R. Guduru, Mélanie Uguen, Juanita Sanchez Rubiano, Xindi Zhang, Fengling Li, Jacqueline L. Norris-Drouin, Matthew Axtman, P. Brian Hardy, Masoud Vedadi, Stephen V. Frye, Lindsey I. James, Kenneth H. Pearce
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 428-439 (2022)
Methyl-lysine (Kme) reader domains are prevalent in chromatin regulatory proteins which bind post-translational modification sites to recruit repressive and activating factors; therefore, these proteins play crucial roles in cellular signaling and ep
Externí odkaz:
https://doaj.org/article/859446a01131470eb8e3880dae7658e0
Autor:
Joselyn Cruz Cruz, Kristen C. Allison, Lauren S. Page, Alexis J. Jenkins, Xiaodong Wang, H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Michael R. Verneris, Alisa B. Lee-Sherick
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process
Externí odkaz:
https://doaj.org/article/6c936b3c3cbd434da91afc7829838a3a
Autor:
Tamara Vital, Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Stephen V. Frye, Amber L. Mosely, Jian Jin, Samantha G. Pattenden, Ian J. Davis
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment o
Externí odkaz:
https://doaj.org/article/7ebda3c984ec4911991fbe839ad7aab9
Autor:
Kelsey N. Lamb, Sarah N. Dishman, Jarod M. Waybright, Isabelle A. Engelberg, Justin M. Rectenwald, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kenneth H. Pearce, Lindsey I. James, Stephen V. Frye
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 716-732 (2021)
Externí odkaz:
https://doaj.org/article/80ec6b26fa154dc6ae4b514e28795b9f
Autor:
Dan Yan, Justus M. Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Subir Goyal, Xiaodong Wang, Stephen V. Frye, Madhusmita Behera, Frank Schneider, Suresh S. Ramalingam, Taofeek Owonikoko, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Acquired resistance is inevitable in non–small cell lung cancers (NSCLCs) treated with osimertinib (OSI), and the mechanisms are not well defined. The MERTK ligand GAS6 promoted downstream oncogenic signaling in EGFR-mutated (EGFRMT) NSCLC cells tr
Externí odkaz:
https://doaj.org/article/dc8fcbaf4b6443d0b3ac710d3a2feecb
Autor:
Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson, Scott B. Rothbart
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent histone and DNA recognition. The ta
Externí odkaz:
https://doaj.org/article/822cc0cfc8954da2b3db79387eec4c34
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce Jr., Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction A chemogenomic set of small molecules with annotated activities and implicated roles in Alzheimer's disease (AD) called the AD Informer Set was recently developed and made available to the AD research community: https://treatad.
Externí odkaz:
https://doaj.org/article/b33c64d9d5fa4d89ad4554a76c6b0930
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat
Externí odkaz:
https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7
Autor:
Hagar F. Moussa, Daniel Bsteh, Ramesh Yelagandula, Carina Pribitzer, Karin Stecher, Katarina Bartalska, Luca Michetti, Jingkui Wang, Jorge A. Zepeda-Martinez, Ulrich Elling, Jacob I. Stuckey, Lindsey I. James, Stephen V. Frye, Oliver Bell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to promote gene silencing. Here the authors use reversible tethering of Polycomb proteins to ectopic sites in mouse ESCs and find that canonical but not variant PRC
Externí odkaz:
https://doaj.org/article/c3dcbf63ea4b486cbed795c1f715237f